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爵床化学成分、药理作用与临床应用的研究进展及其质量标志物预测分析
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作者 曾景 刘傲蕾 +4 位作者 薛永琪 吴和珍 杨艳芳 刘博 艾中柱 《中国药师》 CAS 2024年第8期1445-1458,共14页
爵床主要含有木脂素、黄酮、生物碱等类型的化学成分,临床上常用于辅助治疗疟疾、热病、肺热咳嗽、毒蛇咬伤等疾病。现代药理研究表明其具有抗血小板聚集、镇痛、抗肿瘤和抗炎等多种药理作用。本综述对爵床的本草考证进行了更具体的归纳... 爵床主要含有木脂素、黄酮、生物碱等类型的化学成分,临床上常用于辅助治疗疟疾、热病、肺热咳嗽、毒蛇咬伤等疾病。现代药理研究表明其具有抗血小板聚集、镇痛、抗肿瘤和抗炎等多种药理作用。本综述对爵床的本草考证进行了更具体的归纳,并结合国内外研究对爵床的化学成分、药理作用以及临床应用进行了总结,基于“五原则”及网络药理学、传统药性对爵床的质量标志物(Q-Marker)进行预测分析。初步预测6′-羟基爵床脂定A、6'-羟基爵床脂定B、6'-羟基爵床脂定C、爵床脂定B、金不换甲醚、山奈酚等成分可作为爵床的Q-Marker,以期为更好地开发和利用爵床属植物资源提供借鉴。 展开更多
关键词 爵床 化学成分 药理作用 临床应用 质量标志物 6′-羟基爵床脂定A 6'-羟基爵床脂定B 6'-羟基爵床脂定C 爵床脂定B 金不换甲醚 山奈酚 研究进展
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Non-gyroscope DR and adaptive information fusion algorithm used in GPS/DR device
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作者 Li Qingli xue yongqi +1 位作者 Shang Yanlei Shi Pengfei 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2006年第2期390-395,共6页
In view of the problems existing in GPS, a non-gyroscope DR is introduced. The operating principle and the algorithm of the GPS/DR device are also presented. By operating measured data synthetically, linear observatio... In view of the problems existing in GPS, a non-gyroscope DR is introduced. The operating principle and the algorithm of the GPS/DR device are also presented. By operating measured data synthetically, linear observation equations are obtained for the information fusion algorithm. This approach avoids model error due to linearizing nonlinear observation equations in the conventional algorithm, so that the stability of information fusion algorithm is improved and computation expenses are reduced. Field running experiments show that satisfactory accuracy can be obtained by the proposed navigation model and algorithm for the non-gyroscope GPS/DR device. 展开更多
关键词 non-gyroscope DR GPS integrated navigation system information fusion.
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Study on microscope hyperspectral medical imaging method for biomedical quantitative analysis 被引量:6
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作者 LI QingLi xue yongqi +1 位作者 XIAO GongHai ZHANG JingFa 《Chinese Science Bulletin》 SCIE EI CAS 2008年第9期1431-1434,共4页
A microscopic pushbroom hyperspectral imaging system was developed based on the microscopic technology and spectral imaging technology according to the principle of spectral imager in remote sensing. The basic princip... A microscopic pushbroom hyperspectral imaging system was developed based on the microscopic technology and spectral imaging technology according to the principle of spectral imager in remote sensing. The basic principle and key technologies of this system were presented and the system per- formance was also analyzed. Some methods and algorithms were proposed to preprocess and nor- malize the microscopic hyperspectral data and retrieve the transmittance spectrum of samples. As a case study, the microscopic hyperspectral imaging system was used to image the retina sections of different rats and get some significant results. Experiment results show that the system can be used for the quantitative assessment and evaluating the effect of medication in biomedical research. 展开更多
关键词 显微镜 数量分析 糖尿病性视网膜病变 医学成像技术
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Microscopic hyperspectral imaging studies of normal and diabetic retina of rats 被引量:1
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作者 LI QingLi xue yongqi +1 位作者 ZHANG JingFa XIAO GongHai 《Science China(Life Sciences)》 SCIE CAS 2008年第9期789-794,共6页
A microscopic hyperspectral imager was developed based on the microscopic technology and the spectral imaging technology. Some microscopic hyperspectral images of retina sections of the normal, the diabetic, and the t... A microscopic hyperspectral imager was developed based on the microscopic technology and the spectral imaging technology. Some microscopic hyperspectral images of retina sections of the normal, the diabetic, and the treated rats were collected by the new imager. Single-band images and pseudo-color images of each group were obtained and the typical transmittance spectrums were ex-tracted. The results showed that the transmittance of outer nuclear layer cells of the diabetic group was generally higher than that of the normal. A small absorption peak appeared near the 180th band in the spectrum of the diabetic group and this peak weakened or disappeared in the spectrum of the treated group. Our findings indicate that the microscopic hyperspectral images include wealthy information of retina sections which is helpful for the ophthalmologist to reveal the pathogenesis of diabetic reti-nopathy and explore the therapeutic effect of drugs. 展开更多
关键词 diabetic retinopathy RETINA microscopic hyperspectral imager SPECTRUM
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