Correction: Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMGA2 axis as a competing endogenous RNA

In the article“Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMGA2 axis as a competing endogenous RNA”(Oncology Research,2020,Vol.28,No.5,pp.483–495.doi:10.3727/096504020X15928179818438),there was an error in the processing of data.To further confirm our observation,we repeated multiple experiments involving in this study,including Flow Cytometry,Transwell Cell Migration and Invasion Assays,Xenograft Tumor Model,and Western Blotting.We have revised the figures to correct these errors.Corrected versions of the Figs.2,4,5,6,and 7 are provided.The corrections do not change any results or conclusion of the article.We apologize for any inconvenience caused.

A Positioning Method and Realization on Single Satellites in Different Orbits Using TDOA

The main geolocation technology currently used in COSPAS-SARSAT system is TDOA/FDOA or three-star TDOA,the principle is to determine the location of the signal source by using the difference in arrival time and frequency of the wireless signal between different receivers.Therefore,ground monitoring stations need to be equipped with more than two antenna receiving stations,and multiple satellites should be able to simultaneously relay the distress signal from the target source in order to achieve the geolocation function.However,when the ground receiving system has only one antenna receiving station,or the target source is in a heavily obscured environment,the ground side is unable to receive the forwarded signals from multiple satellites at the same time,which will make it impossible to locate.To address these problems,in this paper,a time-sharing single satellite geolocations method based on different orbits is proposed for the first time.This method uses one or several low-earth orbit satellites(LEO)and mediumearth orbit satellites(MEO)in the visible area,and the receiving station only needs one pair of receiving antennas to complete the positioning.It can effectively compensate for the shortcomings of the traditional TDOA using the same moment and have better positioning accuracy compared with the single satellite in the same orbit.Due to the limited experimental conditions,this paper tests the navigation satellite using different orbit time-sharing single satellite geolocations,and proves that the positioning method has high positioning accuracy and has certain promotion and application value.

Configurational information entropy analysis of fragment mass cross distributions to determine the neutron skin thickness of projectile nuclei

Configurational information entropy(CIE)analysis has been shown to be applicable for determining the neutron skin thickness(δnp)of neutron-rich nuclei from fragment production in projectile fragmentation reactions.The BNN+FRACS machine learning model was adopted to predict the fragment mass cross-sections(σ_(A))of the projectile fragmentation reactions induced by calcium isotopes from ^(36)Ca to ^(56)Ca on a ^(9)Be target at 140MeV/u.The fast Fourier transform was adopted to decompose the possible information compositions inσA distributions and determine the quantity of CIE(S_(A)[f]).It was found that the range of fragments significantly influences the quantity of S_(A)[f],which results in different trends of S_(A)[f]~δnp correlation.The linear S_(A)[f]~δnp correlation in a previous study[Nucl.Sci.Tech.33,6(2022)]could be reproduced using fragments with relatively large mass fragments,which verifies that S_(A)[f]determined from fragmentσAis sensitive to the neutron skin thickness of neutron-rich isotopes.

Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population:a case-control study

Background:MicroRNA(miRNA) polymorphisms may alter miRNA-related processes,and they likely contribute to cancer susceptibility.Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers;however,few studies have focused on head and neck squamous cell carcinoma(HNSCC) risk.This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population.Methods:In this study,we genotyped five common single-nucleotide polymorphisms(SNPs) in several key miRNAs(miR-149 rs2292832,miR-146 a rs2910164,miR-605 rs2043556,miR-608 rs4919510,and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls,which were matched by age and sex in a Chinese population.Results:The results revealed that miR-605 rs2043556[dominant model:adjusted odds ratio(OR) 0.71,95%confidence interval(CI) 0.58-0.88;additive model:adjusted OR 0.74,95%CI 0.62-0.89]and miR-196a2 rs11614913(dominant model:adjusted OR 1.36,95%C11.08-1.72;additive model:adjusted OR 1.28,95%C11.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma(OSCC).Furthermore,when these two loci were evaluated together based on the number of putative risk alleles(rs2043556 A and rs11614913 G),a significant locus-dosage effect was noted on the risk of OSCC(P_(trend) < 0.001).However,no significant association was detected between the other three SNPs(miR-149 rs2292832,miR- 146 a rs2910164,and miR-608 rs4919510) and HNSCC risk.Conclusion:Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.

Effect of operating parameters on the performance of thermally regenerative ammonia-based battery for low-temperature waste heat recovery

This study investigated the important factors that affect the operating parameters of thermally regenerative ammoniabased batteries(TRABs),including the metal electrode type,membrane type,electrode surface area,electrode distance,electrolyte concentration,and ammonia concentration.The experimental results showed that the maximum power density of TRABs with a Cu electrode was 40.0 W·m^(2),which was considerably higher than that with Ni(0.34 W·m^(2))and Co(0.14 W·m^(2))electrodes.TRABs with an anion exchange membrane had a 28.6%higher maximum power density than those with a cation exchange membrane.An increased electrode surface resulted in an increased maximum power but a decreased maximum power density.Within a certain range,TRAB performance was enhanced with decreased electrode distance and increased electrolyte concentration.An increased ammonia concentration resulted in enhanced ammonia transfer and improved the TRAB performance.

Rapid Structure-Based Screening Informs Potential Agents for Coronavirus Disease(COVID-19)Outbreak

Coronavirus Disease 2019(COVID-19),caused by the novel coronavirus,has spread rapidly across China.Consequently,there is an urgent need to sort and develop novel agents for the prevention and treatment of viral infections.A rapid structure-based virtual screening is used for the evaluation of current commercial drugs,with structures of human angiotensin converting enzymeⅡ(ACE2),and viral main protease,spike,envelope,membrane and nucleocapsid proteins.Our results reveal that the reported drugs Arbidol,Chloroquine and Remdesivir may hinder the entry and release of virions through the bindings with ACE2,spike and envelope proteins.Due to the similar binding patterns,NHC(β-d-N4-hydroxycytidine)and Triazavirin are also in prospects for clinical use.Main protease(3 CLpro)is likely to be a feasible target of drug design.The screening results to target 3 CLpro reveal that Mitoguazone,Metformin,Biguanide Hydrochloride,Gallic acid,Caffeic acid,Sulfaguanidine and Acetylcysteine seem be possible inhibitors and have potential application in the clinical therapy of COVID-19.

Progresses on two-phase modeling of proton exchange membrane water electrolyzer

The Proton Exchange Membrane(PEM)water electrolyzer is considered one of the promising energy storing means for harnessing variable renewable energy sources to produce hydrogen.Understanding the internal fluid dynamics,which are often challenging to directly observe experimentally,has prompted the use of numerical models to investigate two-phase flow within PEM water electrolyzers.In this study,we provide a comprehensive review of prior research focusing on two-phase modeling of PEM electrolyzers,encompassing both components at mesoscopic scales and the full electrolyzer at the macroscopic level.We delve into the specifics of various modeling approaches for two-phase flow at different scales and summarize and discuss the current state of the art in the field.Presently,two-phase models for the full electrolyzer predominantly employ a macroscopic homogeneous assumption.However,mesoscopic and microscopic models capable of tracking phase interfaces are limited to components.Challenges persist in integrating various modeling scales into a comprehensive electrolyzer model,particularly in coupling two-phase flow between the channels and porous media.Future efforts should focus on developing multi-scale models and simulating two-phase flow under fluctuating input conditions.Additionally,given the structural similarities between PEM water electrolyzers and PEM fuel cells,we compare and discuss differences in two-phase modeling between the two technologies.This work offers the insights for researchers in the field of modeling of PEM water electrolyzers and even fuel cells.

Graphene oxide modified membrane for alleviated ammonia crossover and improved electricity generation in thermally regenerative batteries

Thermally regenerative batteries(TRBs) are promising for harvesting low-grade waste heat into electrical power. However, the ammonia crossover from anode to cathode causes self-discharge and then leads to the decay of capacity. To alleviate the ammonia crossover and improve electricity generation, a stable graphene oxide(GO) modified anion exchange membrane(AEM) was proposed. Compared with the original AEM, the GO modified AEM with a 39.5% lower ammonia permeability induces a 24.3% higher maximal power output and 20.2% higher energy density in TRBs. Together with the visualization result,it was demonstrated the ammonia crossover was effectively alleviated by GO modifying the AEM not at a cost of the reduced battery performance, indicating the promising application in future TRBs.

Silicon-based decoder for polarization-encoding quantum key distribution

Silicon-based polarization-encoding quantum key distribution(QKD)has been extensively studied due to its advantageous characteris-tics of its low cost and robustness.However,given the difficulty of fabricating polarized independent components on the chip,previ-ous studies have only adopted off-chip devices to demodulate the quantum states or perform polarization compensation.In the cur-rent work,a fully chip-based decoder for polarization-encoding QKD was proposed.The chip realized a polarization state analyzer and compensated for the BB84 protocol without the requirement of additional hardware,which was based on a polarization-to-path conversion method utilizing a polarization splitter-rotator.The chip was fabricated adopting a standard silicon photonics foundry,which was of a compact design and suitable for mass production.In the experimental stability test,an average quantum bit error rate of 0.59%was achieved through continuous operation for 10 h with-out any polarization feedback.Furthermore,the chip enabled the automatic compensation of the fiber polarization drift when utiliz-ing the developed feedback algorithm,which was emulated by a ran-dom fiber polarization scrambler.Moreover,a finite-key secret rate of 240 bps over a fiber spool of 100 km was achieved in the case of the QKD demonstration.This study marks an important step to-ward the integrated,practical,and large-scale deployment of QKD systems.

Anaerobic environment as an efficient approach to improve the photostability of fatty acid photodecarboxylase

Fatty acid photodecarboxylase of Chlorella variabilis NC64A(CvFAP) is a novel photoenzyme with great potential in the treatment of waste lipids and production of sustainable aviation fuel. However, the fragile nature of Cv FAP to blue light is an urgent challenge. Herein, we demonstrated anaerobic environment could significantly improve the photostability of Cv FAP for the first time. The decarboxylation of palmitic acid by Cv FAP for 3 h under anaerobic environment increased pentadecane yield by 44.7% as compared to that under aerobic environment. The residual activity of Cv FAP after blue-light preillumination in the absence of palmitic acid for 0.5 h under anaerobic environment was 80.4%, which was 258.7 times higher than that under aerobic environment. Remarkable accumulation of superoxide radical and singlet oxygen in Cv FAP under aerobic environment led to the poor photostability of Cv FAP. Anaerobic environment helped to mitigate the production of superoxide radical and singlet oxygen in Cv FAP, improving the photostability of Cv FAP.

Composition-specific granulation characteristics of molten slag at improved throughput and high temperature of 1,723 K

Centrifugal granulation is one key step to enable waste heat recovery from the molten slag in the iron and steel industry.Yet,it remains unknown about the granulation characteristics of molten slag with different chemical compositions,especially at high throughput.In this work,we provided an experimental study on centrifugal granulation with four types of molten slags.The stage-specific centrifugal granulation was recorded and analyzed at first.Both effects of atomizer configuration and chemical compositions on granulation were investigated in detail.The cup-type atomizer favors film-mode disintegration and possesses better anti-adhesion capacity although the final granule size was not strongly affected by the atomizer configuration.Most importantly,centrifugal granulation has been demonstrated with appreciable adaptability to composition-specific blast furnace(BF)slag with binary basicity of 0.9-1.3.The present study not only sheds light on the modest effect of the chemical composition of molten slag on centrifugal granulation characteristics,but also gains credit for the adaptivity of CGATER.

Liquid encapsulation in a freezing sessile drop

During the solidification of a sessile drop,the effect of heat exchange from the gaseous environmental medium is generally ignored.However,by combining experimental observations,direct numerical simulations,and a theoretical model,we have demonstrated that the environmental medium,particularly one with high thermal conductivity such as a liquid,has nonnegligible heat exchange with both the drop and the substrate,leading to accelerated cooling of the outer surface of the sessile drop.Consequently,it causes alterations in the geometry of the freezing front and ultimately results in the formation of a solidified shell that encloses the drop.Furthermore,the encapsulated liquid continues to solidify,which induces volume change and consequently changes the final outcome of the freezing process.This study highlights the importance of considering the properties of the environmental medium and provides novel strategies to manipulate the freezing rate and reshape the morphology of the solidified drop.

可再生合成燃料研究进展

能源是支撑人类文明和发展的源泉,自古以来人类社会的每一次重要进步都伴随着能源利用效率的不断提升.然而,化石燃料的过度开采和利用不仅造成了能源危机,而且还导致了温室气体、颗粒物等污染物过量排放所引发的严重环境问题.如何获得可再生的洁净燃料是人类社会可持续发展面临的重要挑战.19世纪中叶,人类已经开展了制备可再生合成燃料方面的探索,发现利用厌氧微生物可以转化生物质制取富含甲烷的燃气.历经160余年的发展,已经形成了多条直接或间接的可再生合成燃料制备途径.本文围绕可再生燃料的电化学合成、光催化转化、热化学转化、微生物转化四种主要合成路线,综述了利用可再生能源转化二氧化碳制备甲烷、醇醚燃料、烷烃柴油、航空燃油等合成燃料的发展历程、重要进展及挑战,为未来的燃料可持续供给提供新思路.

聚乙烯亚胺改性铝-富马酸金属有机骨架CO2吸附特性

通过浸渍法对铝-富马酸金属有机骨架(AlFu)进行聚乙烯亚胺(PEI)改性,采用X射线衍射、傅里叶变换红外光谱、扫描电子显微镜、N2吸脱附及热重分析等手段对改性前后的材料进行了表征.结果表明使用浸渍法成功将PEI分子引入到AlFu骨架中;PEI分子的负载不会破坏AlFu骨架的晶格结构,但会降低其X射线衍射特征峰强度;PEI负载量增多会导致AlFu骨架团聚,使得材料比表面积和孔体积减小.实验研究PEI负载量、吸附温度、CO2分压对PEI改性AlFu吸附特性的影响,结果表明50PEI-AlFu样品在75°C, 0.15 (1 bar=100 kPa)下具有最高的CO2吸附量为2.68 mmol/g,经过9个循环后其CO2吸附性能基本保持稳定.

表面改性水热自生长SnO_(2)碳布电极电化学还原CO_(2)性能

电化学还原CO_(2)是一种有效的CO_(2)转化及利用方法,但是由于CO_(2)在电解质溶液中溶解度较低,限制了其电化学还原性能.为增加电极-溶液-CO_(2)的三相反应界面,本文通过水热自生长的方法在碳布基底上制备SnO_(2)纳米片催化剂,利用三甲氧基硅烷修饰电极使其表面具有疏水性,研究了疏水电极与亲水电极的微观形貌和元素价态,对比了疏水电极与亲水电极的表面浸润性、双电层电容、塔菲尔斜率和电化学阻抗,并在不同电位下进行了电化学还原性能测试.实验结果表明,与亲水电极相比,表面改性后的疏水电极具有更低的塔菲尔斜率和传质阻力,表现出更优的电化学还原性能;在-1.8 V(vs.Ag/AgCl)电解电位下,电流密度为(28.0±0.6)mA cm^(-2),法拉第效率为77.2%±1.9%,比亲水电极的法拉第效率提高了14.7%;经12 h的电解测试后仍可维持72.6%的法拉第效率.

基于水凝胶固态电解质的燃料/电解液储供一体化微型燃料电池

燃料电池是一种能量转化效率高、对环境友好的清洁能源装置,但现有燃料电池需要质子交换膜及燃料储存供应系统,限制了其便携化、微型化的发展.水凝胶作为一种三维交联聚合物网络固态电解质,内部多孔交联结构可实现吸水保水能力,在大比表面上可实现快速的物质传输.为简化燃料电池结构,提高系统便携化、微型化,本文使用循环冻融法制备聚乙烯醇水凝胶,利用水凝胶的保水性和离子导电性,将水凝胶作为燃料电池固态电解质,实现了燃料/电解液储供一体化.本文探究了制备条件对水凝胶电解质溶胀性能及导电性能的影响,结果表明,质量分数为5%的聚乙烯醇水凝胶可达到45%的溶胀率及173.61mS/cm的离子电导率,所组装的燃料电池系统功率密度和电流密度分别达到2.5mW/cm^(2)和15.2mA/cm^(2),使得水凝胶有望提高微型燃料电池便携化.

阳极流道具有微孔阵列的被动式纸基微流体燃料电池性能特性

纸基微流体燃料电池利用纸多孔介质内毛细渗流实现了阴阳极反应物被动输运和自然分隔,去除了质子交换膜和微泵,是基于电化学反应的新一代纸基微流控芯片理想的新型微型电源.针对常规纸基微流体燃料电池存在的燃料传质限制,本文提出阳极流道具有微孔阵列的新型电池结构,利用微孔阵列强化燃料的对流/扩散传质提高电池性能,研究了阴阳极间距、电极长度、燃料浓度及电解液浓度对电池性能特性的影响.研究结果表明,阳极流道内微孔阵列能够强化燃料传质并降低离子传输阻力,使得阳极流道具有微孔阵列的纸基微流体燃料电池最大功率密度提高41.2%;减少阴阳极间距有利于降低离子传输阻力,而且阴极电解液流速大于阳极电解液流速,抑制了燃料渗透,使得电池性能提升;电池性能随燃料和电解液浓度上升先升高后降低.当阴阳极间距为1.0 mm,电极长度为5.0 mm,燃料和电解液浓度均为2.0 mol/L时,电池性能达到最优,其最大功率密度为29.7 mW/cm^2.

Proteomic Analysis of Macrophages:A Potential Way to Identify Novel Proteins Associated with Activation of Macrophages for Tumor Cell Killing

One major mechanism through which macrophages effectively kill tumor cells requires cell to cell contact, indicating that certain molecules expressed on cell surface of activated macrophages may mediate the tumoricidal capability. Tumor necrosis factor （TNF） and nitric oxide （NO） are the two classical mediators of tumor cell death. However, evidence of discrepancy is accumulating indicating these known mediators do not appear to account for the broad and potent tumoricidal activity of macrophages. To obtain a full repertoire of tumoricidal activation-associated membrane proteins, we combined one-dimensional SDS-PAGE with capillary liquid chromatographytandem mass spectrometry （LC-MS/MS）. Using this technique, we identified 454 activated macrophage specifically expressed proteins with extremely high confidence, including most known activation markers of macrophages, such as NO synthase （iNOS）, Ym1, cyclooxygenase, etc. Membrane bound TNF-α was also identified on activated macrophages. However, it was also detected on thioglycolate elicited macrophages, indicating this molecule may not play a key role in conjugation-dependent tumor cell killing. In contrast, although NO has not been assigned as an effector molecule of conjugation-dependent tumoricidal pathway, iNOS was identified from membrane fraction of activated macrophages, suggesting NO may be involved in conjugation-dependent tumoricidal mechanism, because iNOS association with plasma membrane is ideally suited to deliver NO directly into the contacted tumor cells. This research provides not only new insights into macrophage conjugation-dependent tumoricidal mechanisms, but also a valuable data set of macrophage activation associated membrane proteins, thus providing better understanding of the functional mechanisms of macrophages in anti-tumor and other biological processes.

U-shaped association between telomere length and esophageal squamous cell carcinoma risk： a case-control study in Chinese population

Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma （ESCC） was still uncertain. Several telomere length-related single nucleotide polymorphisms （TL- SNPs） in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study （1045 ESCC cases and 1433 controls） to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length （RTL） （median： 1.34） than controls （median： 1.50, P 〈 0.001）. More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk （P 〈 0.001）, with odds ratios （95% confidence interval） equal to 2.40 （1.84- 3.14）, 1.36 （1.03-1.79）, 1.01 （0.76-1.35）, and 1.37 （1.03-1.82） for individuals in the 1st （the shortest）, 2nd, 3rd, and 5th （the longest） quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.

CsPbX_(3)(X=Cl,Br,I)纳米晶的制备及其应用

全无机钙钛矿CsPbX_(3)(X=Cl,Br,I)纳米晶作为一类新型的低成本直接带隙半导体材料,具有优异的光学性质,如吸收系数高、尺寸和发射波长易调节、半峰宽窄、荧光量子产率高等特性,在照明、能源、信息显示和探测等领域表现出巨大的应用潜力,成为材料领域的研究热点。本文从CsPbX_(3)纳米晶的结构组成入手,重点综述了其常见的制备方法如高温热注入法、室温再沉淀法、溶剂热法、液滴微流控法、阴离子交换法等,对常见的形貌尺寸控制策略如反应温度和表面配体进行归纳,以及改善CsPbX_(3)纳米晶稳定性的策略,总结了此类材料在白色发光二极管、电致发光二极管、激光器、光电探测器、太阳能电池等光电领域的应用情况,最后对CsPbX3纳米晶领域存在的问题和面临的挑战进行了分析和评述。