AIM: To investigate the therapeutic effect of umbilical cordblood transplantation (UCBT) on patients with severe viralhepatitis and on liver lesions in rats.METHODS: One hundred and fifty three patients with severevir...AIM: To investigate the therapeutic effect of umbilical cordblood transplantation (UCBT) on patients with severe viralhepatitis and on liver lesions in rats.METHODS: One hundred and fifty three patients with severeviral hepatitis were included in the study between April 1990and July 2002. The patients were treated with adult plasmatransfusion (control), UCBT, plasma exchange (PE) and UCBTcombined with PE (UCBT+PE) respectively. The therapeuticeffectiveness was evaluated by serial determinations of liverfunction, lipids and immune function in all patients beforeand after the treatment. The model of experimental hepaticfailure was constructed in SD rats by injecting carbontetrachloride. Then, the rats were given normal saline, adultplasma or neonate cord blood intraperitoneally. After detectionof liver function, the rats were killed and morphologicalchanges of the liver were microscopically observed.RESULTS: UCBT group and UCBT+PE group had muchbetter improvement in liver and immune functions thancontrol group and PE group. The patients in UCBT+PE grouphad the best clinical efficacy. UCBT was safe and had noside effects. The animal experiment showed significantimprovements in liver function and survival rate in neonatecord blood group as compared with adult plasma group.The histopathology of rat′s liver indicated that neonate cordblood application could decrease the liver injury and increasehepatocellular regeneration.CONCLUSION: UCBT demonstrated a good therapeuticeffect on severe viral hepatitis and no obvious side effects.Umbilical cord blood can attenuate the liver lesions andreproduce hepatocyte. The treatment of UCBT combinedwith PE was much better than that of single plasma exchange, thus UCBT can enhance the therapeutic effect of plasma exchange on severe viral hepatitis.展开更多
The Xigaze ophiolite crops out in the central segment of the Yarlung Zangbo suture zone,southern Tibet(Fig.1).It is characterized by large amounts of ultramafic units with minor mafic rocks.The mafic rocks consist of ...The Xigaze ophiolite crops out in the central segment of the Yarlung Zangbo suture zone,southern Tibet(Fig.1).It is characterized by large amounts of ultramafic units with minor mafic rocks.The mafic rocks consist of gabbros,展开更多
Stream ciphers based on linear feedback shift register(LFSR)are suitable for constrained environments,such as satellite communications,radio frequency identification devices tag,sensor networks and Internet of Things,...Stream ciphers based on linear feedback shift register(LFSR)are suitable for constrained environments,such as satellite communications,radio frequency identification devices tag,sensor networks and Internet of Things,due to its simple hardware structures,high speed encryption and lower power consumption.LFSR,as a cryptographic primitive,has been used to generate a maximum period sequence.Because the switching of the status bits is regular,the power consumption of the LFSR is correlated in a linear way.As a result,the power consumption characteristics of stream cipher based on LFSR are vulnerable to leaking initialization vectors under the power attacks.In this paper,a new design of LFSR against power attacks is proposed.The power consumption characteristics of LFSR can be masked by using an additional LFSR and confused by adding a new filter Boolean function and a flip-flop.The design method has been implemented easily by circuits in this new design in comparison with the others.展开更多
目的:探究芳香疗法联合穴位按摩在缓解顺铂化疗所致恶心呕吐(chemotherapy-induced nausea and vomiting,CINV)中的应用。方法:本研究为一项非随机对照的类试验研究,采用便利抽样法选取2022年1月至2023年6月我院顺铂+紫杉醇方案(TP方案...目的:探究芳香疗法联合穴位按摩在缓解顺铂化疗所致恶心呕吐(chemotherapy-induced nausea and vomiting,CINV)中的应用。方法:本研究为一项非随机对照的类试验研究,采用便利抽样法选取2022年1月至2023年6月我院顺铂+紫杉醇方案(TP方案)化疗的非小细胞肺癌患者为研究对象。将2022年1月~6月化疗的50例非小细胞肺癌患者作为对照组,采用标准止吐方案干预,将2022年7月~12月化疗的50例非小细胞肺癌患者作为芳香组,在标准止吐方案基础上给予芳香疗法吸入干预,将2023年1月~6月化疗的50例非小细胞肺癌患者作为联合组,在标准止吐方案基础上给予芳香疗法联合穴位按摩,比较3组患者急性期(化疗用药24 h内)与延迟期恶心级别、呕吐缓解率及经济成本、护理用时的差异。结果:联合组急性期与延迟性CINV发生率及发生程度均在3组中最低,但3组急性期恶心发生率、发生程度差异无统计学意义(χ^(2)=5.178,P=0.075;Z=5.874,P=0.053),呕吐发生率、发生程度差异有统计学意义(P<0.05)。联合组第2天及第3天的恶心、呕吐发生率及发生程度均最低,3组比较差异均有统计学意义(P<0.05);两两比较显示,联合组、芳香组急性期恶心、呕吐发生率均显著低于对照组(P<0.05),且联合组延迟性恶心、呕吐发生也显著低于对照组(P<0.05),而芳香组与联合组的两两比较,差异均无统计学意义(P>0.05)。联合组生活质量评分最高,其次为芳香组,3组生活质量评分差异有统计学意义(F=8.268,P<0.001),但联合组与芳香组生活质量评分的差异无统计学意义(t=1.890,P=0.062)。联合组的护理成本与护理用时均高于芳香组。结论:芳香疗法可有效减轻急性期CINV症状,而芳香疗法联合穴位按摩不仅能够进一步减轻急性期CINV症状,还可改善延迟性CINV症状,提高患者生活质量,但需要更多的护理用时与费用。提示芳香疗法联合穴位按摩可作为非药物方法控制CINV症状,临床医护人员可在考虑护理用时和费用的情况下选择该干预措施作为辅助疗法。展开更多
基金the National Natural Science Foundation of China, No.39870651
文摘AIM: To investigate the therapeutic effect of umbilical cordblood transplantation (UCBT) on patients with severe viralhepatitis and on liver lesions in rats.METHODS: One hundred and fifty three patients with severeviral hepatitis were included in the study between April 1990and July 2002. The patients were treated with adult plasmatransfusion (control), UCBT, plasma exchange (PE) and UCBTcombined with PE (UCBT+PE) respectively. The therapeuticeffectiveness was evaluated by serial determinations of liverfunction, lipids and immune function in all patients beforeand after the treatment. The model of experimental hepaticfailure was constructed in SD rats by injecting carbontetrachloride. Then, the rats were given normal saline, adultplasma or neonate cord blood intraperitoneally. After detectionof liver function, the rats were killed and morphologicalchanges of the liver were microscopically observed.RESULTS: UCBT group and UCBT+PE group had muchbetter improvement in liver and immune functions thancontrol group and PE group. The patients in UCBT+PE grouphad the best clinical efficacy. UCBT was safe and had noside effects. The animal experiment showed significantimprovements in liver function and survival rate in neonatecord blood group as compared with adult plasma group.The histopathology of rat′s liver indicated that neonate cordblood application could decrease the liver injury and increasehepatocellular regeneration.CONCLUSION: UCBT demonstrated a good therapeuticeffect on severe viral hepatitis and no obvious side effects.Umbilical cord blood can attenuate the liver lesions andreproduce hepatocyte. The treatment of UCBT combinedwith PE was much better than that of single plasma exchange, thus UCBT can enhance the therapeutic effect of plasma exchange on severe viral hepatitis.
文摘The Xigaze ophiolite crops out in the central segment of the Yarlung Zangbo suture zone,southern Tibet(Fig.1).It is characterized by large amounts of ultramafic units with minor mafic rocks.The mafic rocks consist of gabbros,
文摘Stream ciphers based on linear feedback shift register(LFSR)are suitable for constrained environments,such as satellite communications,radio frequency identification devices tag,sensor networks and Internet of Things,due to its simple hardware structures,high speed encryption and lower power consumption.LFSR,as a cryptographic primitive,has been used to generate a maximum period sequence.Because the switching of the status bits is regular,the power consumption of the LFSR is correlated in a linear way.As a result,the power consumption characteristics of stream cipher based on LFSR are vulnerable to leaking initialization vectors under the power attacks.In this paper,a new design of LFSR against power attacks is proposed.The power consumption characteristics of LFSR can be masked by using an additional LFSR and confused by adding a new filter Boolean function and a flip-flop.The design method has been implemented easily by circuits in this new design in comparison with the others.
文摘目的:探究芳香疗法联合穴位按摩在缓解顺铂化疗所致恶心呕吐(chemotherapy-induced nausea and vomiting,CINV)中的应用。方法:本研究为一项非随机对照的类试验研究,采用便利抽样法选取2022年1月至2023年6月我院顺铂+紫杉醇方案(TP方案)化疗的非小细胞肺癌患者为研究对象。将2022年1月~6月化疗的50例非小细胞肺癌患者作为对照组,采用标准止吐方案干预,将2022年7月~12月化疗的50例非小细胞肺癌患者作为芳香组,在标准止吐方案基础上给予芳香疗法吸入干预,将2023年1月~6月化疗的50例非小细胞肺癌患者作为联合组,在标准止吐方案基础上给予芳香疗法联合穴位按摩,比较3组患者急性期(化疗用药24 h内)与延迟期恶心级别、呕吐缓解率及经济成本、护理用时的差异。结果:联合组急性期与延迟性CINV发生率及发生程度均在3组中最低,但3组急性期恶心发生率、发生程度差异无统计学意义(χ^(2)=5.178,P=0.075;Z=5.874,P=0.053),呕吐发生率、发生程度差异有统计学意义(P<0.05)。联合组第2天及第3天的恶心、呕吐发生率及发生程度均最低,3组比较差异均有统计学意义(P<0.05);两两比较显示,联合组、芳香组急性期恶心、呕吐发生率均显著低于对照组(P<0.05),且联合组延迟性恶心、呕吐发生也显著低于对照组(P<0.05),而芳香组与联合组的两两比较,差异均无统计学意义(P>0.05)。联合组生活质量评分最高,其次为芳香组,3组生活质量评分差异有统计学意义(F=8.268,P<0.001),但联合组与芳香组生活质量评分的差异无统计学意义(t=1.890,P=0.062)。联合组的护理成本与护理用时均高于芳香组。结论:芳香疗法可有效减轻急性期CINV症状,而芳香疗法联合穴位按摩不仅能够进一步减轻急性期CINV症状,还可改善延迟性CINV症状,提高患者生活质量,但需要更多的护理用时与费用。提示芳香疗法联合穴位按摩可作为非药物方法控制CINV症状,临床医护人员可在考虑护理用时和费用的情况下选择该干预措施作为辅助疗法。