Background::Air pollution and poor ambient air quality are significantly related to multiple health risks.One associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contri...Background::Air pollution and poor ambient air quality are significantly related to multiple health risks.One associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally.A potentially high-risk population are traffic enforcers who are constantly exposed to air pollution.In the Philippines,the MMDA has the widest coverage in traffic management.The study determined the risk of COPD among Metro Manila Development Authority(MMDA)traffic enforcers in relation to ambient air quality level,as well as identified other factors that increase the risk of developing COPD.Methods::Fifty-two MMDA traffic enforcers deployed in PM 2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified sampling.The International Primary Airways Guidelines(IPAG)questionnaire was utilized to measure risk of COPD.Respiratory health and working history were obtained through questionnaires.Department of environment and natural resources provided PM 2.5 ambient air quality data which aided in the construction of the Exposure-Month Index.Ordinal logistic regression was used to examine the association of PM 2.5 together with the relevant factors and the risk of COPD.Results::We found statistically significant associations between PM 2.5 and COPD among high risk category[odds risk(OR):1.24,95%confidence interval(CI):1.07-1.44].Age(Moderate,OR:1.16,95%CI:0.98-1.38 and High,OR:10.06,95%CI:4.02-25.17)and chest pain(Moderate,OR:68.65,95%CI:1.71-2.75×103)were potential risk factors,whereas body mass index(BMI)(OR:0.05,95%CI:0.01-0.53)exhibited protective effect.Conclusions::Exposure to PM 2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic enforcers.Age and chest pain were potential risk factors to risk of COPD,whereas BMI exhibited a potential protective effect.Results of this study can be used for clinical management of high-risk populations,such that of MMDA traffic enforcers.展开更多
Studies have investigated the effects of heat and temperature variability(TV)on mortality.However,few assessed whether TV modifies the heat-mortality association.Data on daily temperature and mortality in the warm sea...Studies have investigated the effects of heat and temperature variability(TV)on mortality.However,few assessed whether TV modifies the heat-mortality association.Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries.TV was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.展开更多
文摘Background::Air pollution and poor ambient air quality are significantly related to multiple health risks.One associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally.A potentially high-risk population are traffic enforcers who are constantly exposed to air pollution.In the Philippines,the MMDA has the widest coverage in traffic management.The study determined the risk of COPD among Metro Manila Development Authority(MMDA)traffic enforcers in relation to ambient air quality level,as well as identified other factors that increase the risk of developing COPD.Methods::Fifty-two MMDA traffic enforcers deployed in PM 2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified sampling.The International Primary Airways Guidelines(IPAG)questionnaire was utilized to measure risk of COPD.Respiratory health and working history were obtained through questionnaires.Department of environment and natural resources provided PM 2.5 ambient air quality data which aided in the construction of the Exposure-Month Index.Ordinal logistic regression was used to examine the association of PM 2.5 together with the relevant factors and the risk of COPD.Results::We found statistically significant associations between PM 2.5 and COPD among high risk category[odds risk(OR):1.24,95%confidence interval(CI):1.07-1.44].Age(Moderate,OR:1.16,95%CI:0.98-1.38 and High,OR:10.06,95%CI:4.02-25.17)and chest pain(Moderate,OR:68.65,95%CI:1.71-2.75×103)were potential risk factors,whereas body mass index(BMI)(OR:0.05,95%CI:0.01-0.53)exhibited protective effect.Conclusions::Exposure to PM 2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic enforcers.Age and chest pain were potential risk factors to risk of COPD,whereas BMI exhibited a potential protective effect.Results of this study can be used for clinical management of high-risk populations,such that of MMDA traffic enforcers.
基金This study was supported by the Australian Research Council(DP210102076)the Australian National Health and Medical Research Council(APP2000581)+12 种基金Y.W and B.W.were supported by the China Scholarship Council(nos.202006010044 and 202006010043)S.L.was supported by an Emerging Leader Fellowship of the Australian National Health and Medical Research Council(no.APP2009866)Y.G.was supported by Career Development Fellowship(no.APP1163693)and Leader Fellowship(no.APP2008813)of the Australian National Health and Medical Research CouncilJ.K.and A.U.were supported by the Czech Science Foundation(project no.20-28560S)N.S.was supported by the National Institute of Environmental Health Sciences-funded HERCULES Center(no.P30ES019776)Y.H.was supported by the Environment Research and Technology Development Fund(JPMEERF15S11412)of the Environmental Restoration and Conservation AgencyM.d.S.Z.S.C.and P.H.N.S.were supported by the São Paulo Research Foundation(FAPESP)H.O.and E.I.were supported by the Estonian Ministry of Education and Research(IUT34-17)J.M.was supported by a fellowship of Fundação para a Ciência e a Tecnlogia(SFRH/BPD/115112/2016)A.G.and F.S.were supported by the Medical Research Council UK(grant ID MR/R013349/1),the Natural Environment Research Council UK(grant ID NE/R009384/1),and the EU’s Horizon 2020 project,Exhaustion(grant ID 820655)A.S.and F.d.D.were supported by the EU’s Horizon 2020 project,Exhaustion(grant ID 820655)V.H.was supported by the Spanish Ministry of Economy,Industry and Competitiveness(grant ID PCIN-2017-046)A.T.byMCIN/AEI/10.13039/501100011033(grant CEX2018-000794-S).Statistics South Africa kindly provided the mortality data,but had no other role in the study.
文摘Studies have investigated the effects of heat and temperature variability(TV)on mortality.However,few assessed whether TV modifies the heat-mortality association.Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries.TV was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.