In a quest for better chelating therapy drugs for the treatment of intoxication by Fe, A1, or actinides, two new series of mixed catechol-bisphosphonate through amide linkage were synthesized. Benzyl group was used as...In a quest for better chelating therapy drugs for the treatment of intoxication by Fe, A1, or actinides, two new series of mixed catechol-bisphosphonate through amide linkage were synthesized. Benzyl group was used as protecting group to avoid the breakage of amide by acid hydrolysis or imcomplete reaction in silylation-dealkylation using bromotrimethylsilane.展开更多
In our effoft to asymmetric synthesis of R-(+)-shikonin, a novel acetyl ndgration was found, and the mechanism of the ndgration was considered to be mediated by a 6 atom-ring intermediate.
文摘In a quest for better chelating therapy drugs for the treatment of intoxication by Fe, A1, or actinides, two new series of mixed catechol-bisphosphonate through amide linkage were synthesized. Benzyl group was used as protecting group to avoid the breakage of amide by acid hydrolysis or imcomplete reaction in silylation-dealkylation using bromotrimethylsilane.
文摘In our effoft to asymmetric synthesis of R-(+)-shikonin, a novel acetyl ndgration was found, and the mechanism of the ndgration was considered to be mediated by a 6 atom-ring intermediate.
