Carotid versus axillary artery cannulation for descending aorta remodeling in type A acute aortic dissection

BACKGROUND Arterial cannulation sites for the surgical repair of type A aortic dissection(AAD)have evolved from right axillary artery(AA)cannulation to bilateral carotid artery(CA)based of femoral artery(FA)cannulation.Postoperative descending aorta remodeling is closely linked to the false lumen area ratio(FLAR),defined as false lumen area/aortic area,as well as to the incidence of renal replacement therapy(RRT).AIM To investigate the effect of the updated arterial cannulation strategy on descending aortic remodeling.METHODS A total of 443 AAD patients who received FA combined cannulation between March 2015 and March 2023 were included in the study.Of these,209 received right AA cannulation and 234 received bilateral CA cannulation.The primary outcome was the change in FLAR,as calculated from computed tomography angiography in three segments of the descending aorta:Thoracic(S1),upper abdominal(S2),and lower abdominal(S3).Secondary outcomes were the incidence of RRT and the serum inflammation response,as observed by the levels of high sensitivity C reaction protein(hs-CRP)and Interleukin-6(IL-6).RESULTS The postoperative/preoperative ratio of FLAR in S2 and S3 was higher in the AA group compared to the CA group(S2:0.80±0.08 vs 0.75±0.07,P<0.001;S3:0.57±0.12 vs 0.50±0.12,P<0.001,respectively).The AA group also had a significantly higher incidence of RRT(19.1%vs 8.5%,P=0.001;odds ratio:2.533,95%CI:1.427-4.493)and higher levels of inflammation cytokines 24 h after the procedure[hr-CRP:117±17 vs 104±15 mg/L;IL-6:129(103,166)vs 83(69,101)pg/mL;both P<0.001]compared to the CA group.CONCLUSION The CA cannulation strategy was associated with better abdominal aorta remodeling after AAD repair compared to AA cannulation,as observed by a greater change in FLAR and lower incidence of RRT.

Silicon dioxide nanoparticles inhibit the effects of cold exposure on metabolism and inflammatory responses in brown adipocytes

Objective:Nanoparticles(NPs)in haze are potentially hazardous to health,which is more severe in the winter.Brown adipose tissue(BAT)plays important roles in obesity,insulin resistance,and diabetes.Though the toxicology of NPs has been intensively studied,few studies have been reported on the antagonistic effects between Silicon dioxide(SiO_(2))NPs and cold exposure in brown adipocytes.Materials and methods:We evaluated changes by quantitative real-time reverse-transcriptase polymerase chain reaction(qRT-PCR)on metabolism genes,plasticity genes and the inflammatory responses genes in brown adipocytes in vitro.Results:The expression of adipogenic genes PRDM16,Dio2,PGC-1αand UCP1 was upregulated upon cold exposure(P<0.05),but downregulated by SiO_(2) NPs(P<0.05).The results demonstrated that there was antagonistic effect between SiO_(2) NPs and cold exposure on the plasticity genes and metabolism genes in brown adipocytes,where the main effects of SiO_(2) NPs or cold exposure on the plasticity genes and metabolism genes were significant(P<0.05).Moreover,the levels of interleukin(IL)-1β,IL-6 and tumor necrosis factor(TNF)-αwere upregulated by SiO_(2) NPs or cold exposure(P<0.05).The factorial analysis indicated that there was also antagonistic effect between SiO_(2) NPs and cold exposure on the toxic effects in brown adipocytes,in which the main effects of cold exposure and/or SiO_(2) NPs on the toxic effects were significant(P<0.05).Conclusion:SiO_(2) NPs inhibit the effect of cold exposure on metabolic genes and inflammatory responses genes in brown adipocytes.

Metal-organic cage as fluorescent probe for LiPF_(6)in lithium batteries

Lithium hexafluorophosphate(LiPF_(6)),the most commonly used lithium battery electrolyte salt,is vulnerable to heat and humidity.Quantitative and qualitative determination the variation of LiPF_(6)have always relied on advanced equipment.Herein,we develop a fast,convenient,high-selective fluorescence detection method based on metal-organic cages(MOC),whose emission is enhanced by nearly 20 times in the presence of LiPF_(6)with good stability and photobleaching resistance.The fluorescent probe can also detect moisture in battery electrolyte.We propose and verify that the luminescence enhancement is due to the presence of hydrogen bond-induced enhanced emission effect in cages.Fluorescent excitation-emission matrix spectra and variable-temperature nuclear magnetic resonance spectroscopy are employed to clarify the role of hydrogen bonds in guest-loaded cages.Density functional theory(DFT)calculation is applied to simulate the structure of host-guest complexes and estimate the adsorption energy involved in the system.The precisely matched lock-and-key model paves a new way for designing and fabricating novel host structures,enabling specific recognition of other target compounds.

Clinical Study on the Treatment of Senile Alzheimer’s Dementia with Sodium Oligomannate Combined with Memantine Hydrochloride

Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects.The patients were divided into two groups based on different treatment methods:the control group(treated with memantine hydrochloride,34 cases)and the treatment group(treated with sodium oligomannate+memantine hydrochloride,34 cases).Cognitive function,activities of daily living,neurotransmitters,serum intestinal flora metabolic markers,inflammatory factors,neurotrophic factors,and adverse reactions were compared between the two groups.Results:The treatment group showed better cognitive function,quality of life scores,and levels of relevant metabolic markers in the body compared to the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions between the two groups(treatment group:2%;control group:4%)was not statistically significant(χ^(2)=0.731,P=0.393).Conclusion:Sodium oligomannate combined with memantine hydrochloride has better efficacy than the control group for treating senile Alzheimer’s dementia.It significantly improves and restores cognitive function and daily living abilities,benefits neurotransmitter secretion and internal regulation,upregulates the expression of neurotrophic factors,and has fewer adverse reactions,making it a treatment worthy of further clinical promotion and application.

Oxidative coupling of alcohols and amines to an imine over Mg-Al acid-base bifunctional oxide catalysts

A series of Mg‐Al mixed oxide catalysts are prepared and introduced as efficient irreducible catalysts for the oxidative coupling of alcohols and amines to imine.The structure and surface properties of Mg‐Al oxides are modulated by changing the Mg/Al ratios,calcination temperature and treatment with probe molecules.Detailed characterization,including X‐ray diffraction,27Al magic angle spinning nuclear magnetic resonance spectroscopy,N2‐adsorption,NH3‐temperature‐programmed desorption,CO2‐temperature‐programmed desorption and X‐ray photoelectron spectroscopy are carried out to determine the physicochemical properties of these catalysts.The Mg‐Al oxides with Mg/Al=3exhibit the highest activity in the reaction,which possess a large number of surface weak basic sites and a relatively small number of weak acidic sites.The role of the acidic and basic sites in the reaction process is systematically investigated,and are shown to serve as adsorption and activation sites for amines and alcohols,respectively.Under the synergistic effect of these acid‐base centers,the oxidative coupling process successfully occurs on the surface of Mg‐Al mixed oxides.Compared with the acidic sites,the weak basic sites play a more important role in the catalytic process.The acidic sites are the catalytic centers for the benzyl alcohol activation,which control the reaction rate of the oxidative coupling reaction.

Solid-state mechanochemistry advancing two dimensional materials for lithium-ion storage applications:A mini review

The vigorous development of two-dimensional(2D)materials brings about numerous opportunities for lithiumion batteries(LIBs)due to their unique 2D layered structure,large specific surface area,outstanding mechanical and flexibility properties,etc.Modern technologies for production of 2D materials include but are not limited to mechanochemical(solid-state/liquid-phase)exfoliation,the solvothermal method and chemical vapor deposition.In this review,strategies leading to the production of 2D materials via solid-state mechanochemistry featuring traditional high energy ball-milling and Sichuan University patented pan-milling are highlighted.The mechanism involving exfoliation,edge selective carbon radical generation of the 2D materials is delineated and this is followed by detailed discussion on representative mechanochemical techniques for tailored and improved lithium-ion storage performance.In the light of the advantages of the solid-state mechanochemical method,there is great promise for the commercialization of 2D materials for the next-generation high performance LIBs.

乡村文化振兴与环境设计研究--以乡村文化空间设计为视角

文化是乡村的精神传承,文化振兴是实现乡村振兴的灵魂所在。环境设计作为连接人与空间的桥梁,其对乡村文化振兴的作用不言而喻。本文旨在探究乡村文化振兴与环境设计之间的相互作用,并以乡村文化空间为例,分析乡村文化传承与发展,发挥环境设计的学科优势,充分探讨乡村文化振兴的价值意义。

Full-chain enhanced ion transport toward stable lithium metal anodes

The dendrite growth that results from the slow electrode process kinetics prevents the lithium(Li) metal anode from being used in practical applications. Here, full-chain enhanced ion transport for stabilizing Li metal anodes is proposed. Experimental and theoretical studies confirm that full-chain enhanced ion transport(electrocrystallization, mass transport in the electrolyte and diffusion in solid electrolyte interphase) under magnetoelectrochemistry contributes to a homogeneous, dense, and dendrite-free morphology. Specifically, the enhanced electrocrystallization behavior promotes the Li nucleation;the enhanced mass transport in the electrolyte alleviates the ion concentration gradient at the electrode surface, which helps to inhibit dendrite growth;and the enhanced diffusion in the solid electrolyte interphase further homogenizes the Li deposition behavior, obtaining regular and uniform Li particles.Consequently, the Li metal anode has exceptional cycling stability in both symmetric and full cells,and the pouch cell performs long cycles(170 cycles) in practice evaluation. This work advances fundamental knowledge of the magneto-dendrite effect and offers a new perspective on stabilizing metal anodes.

Research progress on adaptive modifications of the gut microflora and regulation of host glucose and lipid metabolism by cold stimulation

The gut microflora is a combination of all microbes in intestine and their microenvironment,and its change can sensitively reflect the relevant response of the body to external environment and remarkably affect body's metabolism as well.Recent studies have found that cold exposure affects the body's gut microflora,which can lead to changes in the body's metabolism of glucose and lipid.This review summarizes recent research on the effects of cold exposure on gut microbes and metabolism of glucose and lipid,aiming to provide some new ideas on the approaches and measures for the prevention and treatment of diabetes and obesity.

基于三螺旋理论的环境设计专业“专创融合”育人路径研究

文章将三螺旋理论引入我国高校创新创业教育的研究中,致力于以一个新颖的视角来探讨我国创业教育的发展。文章首先对相关概念、基础理论进行研究和阐述,其次以三螺旋理论为框架,分析了我国高校环境设计专业教育的现状、存在的主要问题及其成因,最后提出以高校为主体、企业为支撑、政府为主导的环境设计专业“专创融合”育人路径。以期为现阶段我国的创新创业教育实践提供指导,助推设计类专业高质量人才培养的进程。

基于老年友好理念的城市居住区公共空间设计研究

人口老龄化发展至今已经成为全球性的社会问题。我国人口老龄化速度快、来势猛、后劲足、“未富先老”问题突出、养老任务严峻。科学数据显示,社会交往活动对于提升老年人获得感、安全感、幸福感,实现积极老龄化和健康老龄化的目标具有积极意义。文章首先通过调研分析了老年人的相关特征,其次分析了城市居住区公共空间的现存问题,最后提出了基于老年友好理念的城市居住公共空间设计思路。以期为老年人提供交往及活动的空间,构建老龄友好型社会,提升老年人的健康幸福指数。

On the Innovation,Design,Construction,and Experiments of OMEGA-Based SSPS Prototype:The Sun-Chasing Project

This study systematically introduces the development of the world’s first full-link and full-system ground demonstration and verification system for the OMEGA space solar power satellite(SSPS).First,the OMEGA 2.0 innovation design was proposed.Second,field-coupling theoretical models of sunlight concentration,photoelectric conversion,and transmitting antennas were established,and a systematic optimization design method was proposed.Third,a beam waveform optimization methodology considering both a high beam collection efficiency and a circular stepped beam shape was proposed.Fourth,a control strategy was developed to control the condenser pointing toward the sun while maintaining the transmitting antenna toward the rectenna.Fifth,a high-efficiency heat radiator design method based on bionics and topology optimization was proposed.Sixth,a method for improving the rectenna array’s reception,rectification,and direct current(DC)power synthesis efficiencies is presented.Seventh,high-precision measurement technology for high-accuracy beam-pointing control was developed.Eighth,a smart mechanical structure was designed and developed.Finally,the developed SSPS ground demonstration and verification system has the capacity for sun tracking,a high concentration ratio,photoelectric conversion,microwave conversion and emission,microwave reception,and rectification,and thus satisfactory results were obtained.

嗜吞噬细胞无浆体MSP4蛋白的原核表达及其多克隆抗体制备

【目的】利用原核表达系统表达嗜吞噬细胞无浆体(Anaplasma phagocytophilum,AP)MSP4蛋白,并制备抗MSP4蛋白的多克隆抗体,为嗜吞噬细胞无浆体检测方法的建立提供试验材料和理论依据。【方法】根据GenBank公布的MSP 4基因优化并合成MSP 4基因,将其插入pET-30a载体,构建pET-30a-MSP4重组质粒,转化大肠杆菌BL21(DE3)感受态细胞,对影响表达效果的因素(温度和IPTG)进行优化,选择最佳诱导表达条件,经SDS-PAGE分析蛋白表达情况,重组蛋白经Ni-IDA亲和层析纯化,并进行SDS-PAGE和Western blotting鉴定。用纯化后的重组蛋白MSP4免疫新西兰大白兔制备兔源多克隆抗体,利用间接ELISA和Western blotting检测多克隆抗体效价及特异性。【结果】本研究成功构建pET-30a-MSP4重组质粒,在37℃、0.8 mmol/L IPTG诱导条件下蛋白表达量较高,表达的重组蛋白分子质量约为28 ku,以包涵体形式存在。Western blotting鉴定结果显示,其免疫原性较好。获得的多克隆抗体效价分别为1∶64000(家兔1)和1∶128000(家兔2),且能与表达的重组蛋白MSP4发生特异性反应,具有较好的免疫原性。【结论】本研究成功表达纯化了嗜吞噬细胞无浆体MSP4蛋白,并制备了其多克隆抗体,可为嗜吞噬细胞无浆体抗原抗体检测方法的建立及疫苗效果评估提供参考,也为MSP4蛋白功能研究奠定基础。

株洲先进硬质材料产业集群数字化高技能人才培养路径

数字化高技能人才是数字经济时代产业集群转型升级的核心驱动力。相关调研数据显示,先进硬质材料产业集群对高技能人才的数字化能力提出了新的要求。高职院校人才培养模式要适应数字化的变革与转型,通过设定数字化人才培养目标、创新课程体系建设、培育双师型师资队伍、深化校企合作办学等路径,为先进硬质材料产业集群输出更多高质量的数字化高技能人才。

基于云边协同的燃煤机组热力性能在线分析平台设计与实践

为了动态掌握燃煤机组热力性能,强化节能减排监管,设计了基于云边协同的燃煤机组热力性能在线分析平台。详细分析了主要性能指标的计算模型,提出了云边协同系统架构和业务功能,并以某1000 MW机组为例进行热力特性分析和灵敏度分析,测试结果较准确反映机组实际特性,从而验证了方案的可行性。平台在电网深度应用,可为强化节能减排监管提供数据支撑,有助于“双碳”目标实现和新型电力系统构建。

Characterization of cerebrovascular changes in Alzheimer's disease mice by photoacoustic imaging

The cerebral vasculature plays a significant role in the development of Alzheimer's disease(AD),however,the specific association between them remains unclear.In this paper,based on the benefits of photoacoustic imaging(PAI),including label-free,high-resolution,in vivo imaging of vessels,we investigated the structural changes of cerebral vascular in wild-type(WT)mice and AD mice at different ages,analyzed the characteristics of the vascular in different brain regions,and correlated vascular characteristics with cognitive behaviors.The results showed that vascular density and vascular branching index in the cortical and frontal regions of both WT and AD mice decreased with age.Meanwhile,vascular lacunarity increased with age,and the changes in vascular structure were more pronounced in AD mice.The trend of vascular dysfunction aligns with the worsening cognitive dysfunction as the disease progresses.Here,we utilized in vivo PAI to analyze the changes in vascular structure during the progression of AD,elucidating the spatial and temporal correlation with cognitive impairment,which will provide more intuitive data for the study of the correlation between cerebrovascular and the development of AD.

A Novel Graph Structure Learning Based Semi-Supervised Framework for Anomaly Identification in Fluctuating IoT Environment

With the rapid development of Internet of Things(IoT)technology,IoT systems have been widely applied in health-care,transportation,home,and other fields.However,with the continuous expansion of the scale and increasing complexity of IoT systems,the stability and security issues of IoT systems have become increasingly prominent.Thus,it is crucial to detect anomalies in the collected IoT time series from various sensors.Recently,deep learning models have been leveraged for IoT anomaly detection.However,owing to the challenges associated with data labeling,most IoT anomaly detection methods resort to unsupervised learning techniques.Nevertheless,the absence of accurate abnormal information in unsupervised learning methods limits their performance.To address these problems,we propose AS-GCN-MTM,an adaptive structural Graph Convolutional Networks(GCN)-based framework using a mean-teacher mechanism(AS-GCN-MTM)for anomaly identification.It performs better than unsupervised methods using only a small amount of labeled data.Mean Teachers is an effective semi-supervised learning method that utilizes unlabeled data for training to improve the generalization ability and performance of the model.However,the dependencies between data are often unknown in time series data.To solve this problem,we designed a graph structure adaptive learning layer based on neural networks,which can automatically learn the graph structure from time series data.It not only better captures the relationships between nodes but also enhances the model’s performance by augmenting key data.Experiments have demonstrated that our method improves the baseline model with the highest F1 value by 10.4%,36.1%,and 5.6%,respectively,on three real datasets with a 10%data labeling rate.

地锦草总黄酮对罗斯308肉鸡生长性能、免疫功能、抗氧化能力及盲肠菌群的影响

试验旨在研究地锦草总黄酮对罗斯308肉鸡生长性能、免疫功能、抗氧化能力及盲肠菌群的影响。选取240只1日龄雄性罗斯308肉鸡随机分为3组,每组4个重复,每个重复20只鸡,试验期42 d。对照组饲喂基础日粮,地锦草总黄酮组饲喂基础日粮+300 mg/kg地锦草总黄酮,土霉素组饲喂基础日粮+200 mg/kg土霉素。结果显示:与对照组相比,地锦草总黄酮组1~21日龄和1~42日龄平均日增重显著升高(P<0.05),料重比显著降低(P<0.05),与土霉素组无显著差异(P>0.05);地锦草总黄酮组血清免疫球蛋白水平显著高于对照组(P<0.05),免疫器官指数显著高于对照组和土霉素组(P<0.05);地锦草总黄酮组血清超氧化物歧化酶和谷胱甘肽过氧化物酶活性显著高于对照组和土霉素组(P<0.05),丙二醛含量显著低于对照组和土霉素组(P<0.05);地锦草总黄酮组盲肠菌群多样性显著高于土霉素组(P<0.05);在科和属水平上,地锦草总黄酮组普雷沃氏菌科、p_251_o5菌科及其未培养菌属、螺旋体科及密螺旋体2属、纤维杆菌科及纤维杆菌属和WCHB1_41未培养菌科及未培养菌属等有益微生物的相对丰度显著高于对照组和土霉素组(P<0.05);莫拉菌科及不动杆菌属、动球菌科及土源芽孢杆菌属和赖氨酸芽孢杆菌属显著富集于土霉素组(P<0.05)。研究表明,罗斯308肉鸡日粮中添加300 mg/kg地锦草总黄酮能够替代土霉素,增强肉鸡生长性能、免疫功能和抗氧化能力,提高盲肠菌群的多样性及有益菌比例,从而在饲料替抗中具有一定应用潜力和良好开发前景。

新生儿急性心功能不全1例

患儿男,1日龄,因生后6h出现低血糖伴呼吸暂停入院。患儿生后早期有一过性低血糖,生后第8天突发急性心功能不全,实验室检查示促肾上腺皮质激素和皮质醇水平显著降低,垂体磁共振成像正常。基因检测结果示患儿存在TBX19基因可疑致病性复合杂合突变(c.917-2A>G+c.608C>T),分别来自父母。该患儿明确诊断为TBX19基因变异导致的先天性孤立性促肾上腺皮质激素缺乏症。给予氢化可的松替代治疗后,心功能迅速恢复正常。出院后继续予氢化可的松替代治疗,随访至18月龄,生长发育良好。新生儿期不明原因的急性心功能不全需警惕内分泌遗传代谢性疾病,应及时行皮质醇及基因检测。

Re-Distributing Facial Features for Engagement Prediction with ModernTCN

Automatically detecting learners’engagement levels helps to develop more effective online teaching and assessment programs,allowing teachers to provide timely feedback and make personalized adjustments based on students’needs to enhance teaching effectiveness.Traditional approaches mainly rely on single-frame multimodal facial spatial information,neglecting temporal emotional and behavioural features,with accuracy affected by significant pose variations.Additionally,convolutional padding can erode feature maps,affecting feature extraction’s representational capacity.To address these issues,we propose a hybrid neural network architecture,the redistributing facial features and temporal convolutional network(RefEIP).This network consists of three key components:first,utilizing the spatial attention mechanism large kernel attention(LKA)to automatically capture local patches and mitigate the effects of pose variations;second,employing the feature organization and weight distribution(FOWD)module to redistribute feature weights and eliminate the impact of white features and enhancing representation in facial feature maps.Finally,we analyse the temporal changes in video frames through the modern temporal convolutional network(ModernTCN)module to detect engagement levels.We constructed a near-infrared engagement video dataset(NEVD)to better validate the efficiency of the RefEIP network.Through extensive experiments and in-depth studies,we evaluated these methods on the NEVD and the Database for Affect in Situations of Elicitation(DAiSEE),achieving an accuracy of 90.8%on NEVD and 61.2%on DAiSEE in the fourclass classification task,indicating significant advantages in addressing engagement video analysis problems.