LAPTM4B,which is a proto-oncogene,plays important roles in cancer progression,including clinical stages and pathologic grades.[1]The LAPTM4B gene encodes the lysosomal-associated protein transmembrane-4 beta(LAPTM4B)p...LAPTM4B,which is a proto-oncogene,plays important roles in cancer progression,including clinical stages and pathologic grades.[1]The LAPTM4B gene encodes the lysosomal-associated protein transmembrane-4 beta(LAPTM4B)protein and LAPTM4B is cloned from hepatocellular carcinoma(HCC).[2]There is increasing evidence that LAPTM4B is a novel oncogene,which is over-expressed in many human solid tumors.[3]Furthermore,the up-regulation of LAPTM4B is associated with chemotherapy resistance,as well as poor clinical outcomes and prognoses.[4,5]LAPTM4B also promotes cell survival,growth,proliferation,metastasis,tolerance to metabolic stress,and autophagy.[6]Thus,the LAPTM4B protein may represent an excellent candidate for individualized treatment and tumor monitoring.展开更多
基金supported by the grants from the Natural Science Foundation of China(No.31670952)the Fundamental Research Funds for the Central Universities(No.106112017CDJXSYY0001)Graduate Research and Innovation Foundation of Chongqing(No.CYB19043)。
文摘LAPTM4B,which is a proto-oncogene,plays important roles in cancer progression,including clinical stages and pathologic grades.[1]The LAPTM4B gene encodes the lysosomal-associated protein transmembrane-4 beta(LAPTM4B)protein and LAPTM4B is cloned from hepatocellular carcinoma(HCC).[2]There is increasing evidence that LAPTM4B is a novel oncogene,which is over-expressed in many human solid tumors.[3]Furthermore,the up-regulation of LAPTM4B is associated with chemotherapy resistance,as well as poor clinical outcomes and prognoses.[4,5]LAPTM4B also promotes cell survival,growth,proliferation,metastasis,tolerance to metabolic stress,and autophagy.[6]Thus,the LAPTM4B protein may represent an excellent candidate for individualized treatment and tumor monitoring.
