This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12...This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12 and 14-membered rings were realized.The control experiment,indene-product curve and density functional theory calculations showed that the η^(3)-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate.We speculate that the final product was obtained through a Pd(IV)intermediate or aryl ligand exchange.In addition,we excluded the formation of palladium anion(Pd(0)^(-))intermediates.展开更多
We report a visible light promoted carbochloromethylation of 2-bromomethyl acrylate and N-arylmethacrylamide,and a series of trihalomethyl substituted allylic acid esters and indolone derivatives were synthesized.The ...We report a visible light promoted carbochloromethylation of 2-bromomethyl acrylate and N-arylmethacrylamide,and a series of trihalomethyl substituted allylic acid esters and indolone derivatives were synthesized.The reaction used common and inexpensive chloroform and tribromomethane as tri-halomethyl reagents,iodobenzene diacetate(PIDA)as an oxidant and Eosin Y as a photocatalyst.The reaction conditions are mild and the substrate scope is wide.展开更多
A catalytic synthesis of N-benzothiazol-2-yl-amides from 1-acyl-B-(phenyl)thioureas was achieved in the presence of a palladium catalyst through the C(sp2)-H functionalization/C-S bond formation, This synthetic me...A catalytic synthesis of N-benzothiazol-2-yl-amides from 1-acyl-B-(phenyl)thioureas was achieved in the presence of a palladium catalyst through the C(sp2)-H functionalization/C-S bond formation, This synthetic methodology can produce various N-benzothiazol-2-yl-amides in high yields with good functional group tolerance.展开更多
A metal-flee synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2- yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amine...A metal-flee synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2- yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives.展开更多
A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3,4-dihydropyrimidine-2-thiones and copper(Ⅰ) carboxylates were performed in the presence of palladium acetate.The copper(Ⅰ) ...A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3,4-dihydropyrimidine-2-thiones and copper(Ⅰ) carboxylates were performed in the presence of palladium acetate.The copper(Ⅰ) carboxylates act not only as desulfurative reagents but also as sources of carbon nudeophiles.A wide array of highly substituted and functionalized pyrimidines scaffolds were synthesized in good yields.展开更多
We report the highly efficient conversion of readily available biomass-derived polyols with amines to valuable furfurylamines orβ-amino alcohols compounds using ruthenium catalysis.The reaction outcome is readily tun...We report the highly efficient conversion of readily available biomass-derived polyols with amines to valuable furfurylamines orβ-amino alcohols compounds using ruthenium catalysis.The reaction outcome is readily tuned by the simple addition of 4Åmolecular sieves(furfurylamines vs.β-amino alcohols)with high chemo-selectivity.The proposed reaction mechanism involves ruthenium-catalyzed hydrogen borrowing for the reduction of the imine intermediate and C–C bond cleavage of polyols via a retro-aldol process.A series of arylamines was suc-cessfully transformed into the desired products with moderate to good yields.展开更多
基金the National Natural Science Foundation of China(Nos.NSF22061038,NSF22067018)the Long Yuan Youth Innovative Project of Gansu Province(No.2019-39)+1 种基金the Northwest Normal University Young Scholars Research Capacity Improvement Program(No.NWNU-LKQN-2020-04)Computations reported in this paper were performed on the computer clusters at the Centre for Scientific Modeling and Computation,CUHK.
文摘This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12 and 14-membered rings were realized.The control experiment,indene-product curve and density functional theory calculations showed that the η^(3)-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate.We speculate that the final product was obtained through a Pd(IV)intermediate or aryl ligand exchange.In addition,we excluded the formation of palladium anion(Pd(0)^(-))intermediates.
基金financially supported by Key Laboratory of Hexi Corridor Resources Utilization of Gansu Universities(No.XZ1011 )the President's Funds of Hexi University(No.XZ-2009-9)the National Natural Science Foundation of China(No.21262010)
文摘Received 20 November 2012 Received in revised form 13 December 2012 Accepted 21 December 2012 Available online 29 January 2013
基金We acknowledge the financial support from the National Natural Science Foundation of China(No.22061038,22067018,22101232)the Key Talent Projects of Gansu Province([2019]39)the Natural Science Foundation of Gansu(No.20YF3GA023,20JR5RA210).
文摘We report a visible light promoted carbochloromethylation of 2-bromomethyl acrylate and N-arylmethacrylamide,and a series of trihalomethyl substituted allylic acid esters and indolone derivatives were synthesized.The reaction used common and inexpensive chloroform and tribromomethane as tri-halomethyl reagents,iodobenzene diacetate(PIDA)as an oxidant and Eosin Y as a photocatalyst.The reaction conditions are mild and the substrate scope is wide.
基金supported by the National Natural Science Foundation of China(Nos.21462016,21262010)Natural Science Foundation of Gansu Province and the Advanced Research Fund of Jinchuan Group Co.,Ltd
文摘A catalytic synthesis of N-benzothiazol-2-yl-amides from 1-acyl-B-(phenyl)thioureas was achieved in the presence of a palladium catalyst through the C(sp2)-H functionalization/C-S bond formation, This synthetic methodology can produce various N-benzothiazol-2-yl-amides in high yields with good functional group tolerance.
基金Financial support was provided by the financial support from the NSFC (Nos.21362032 and 21362031)the Natural Science Foundation of Gansu Province (No.1208RJYA083)Gansu Provincial Department of Finance and the Education Department of Gansu Province (No.2013B-010)
文摘A metal-flee synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2- yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives.
基金Financial support from the National Natural Science Foundation of China(Nos.21362032 and 21362031)the NSF of Gansu Province(No.1208RJYA083)
文摘A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3,4-dihydropyrimidine-2-thiones and copper(Ⅰ) carboxylates were performed in the presence of palladium acetate.The copper(Ⅰ) carboxylates act not only as desulfurative reagents but also as sources of carbon nudeophiles.A wide array of highly substituted and functionalized pyrimidines scaffolds were synthesized in good yields.
基金support from the National Natural Science Foundation of China(NSFC,Nos.21633013,22022204).
文摘We report the highly efficient conversion of readily available biomass-derived polyols with amines to valuable furfurylamines orβ-amino alcohols compounds using ruthenium catalysis.The reaction outcome is readily tuned by the simple addition of 4Åmolecular sieves(furfurylamines vs.β-amino alcohols)with high chemo-selectivity.The proposed reaction mechanism involves ruthenium-catalyzed hydrogen borrowing for the reduction of the imine intermediate and C–C bond cleavage of polyols via a retro-aldol process.A series of arylamines was suc-cessfully transformed into the desired products with moderate to good yields.