Reductive Coupling of Aryl Halides via C-H Activation of Indene

This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12 and 14-membered rings were realized.The control experiment,indene-product curve and density functional theory calculations showed that the η^(3)-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate.We speculate that the final product was obtained through a Pd(IV)intermediate or aryl ligand exchange.In addition,we excluded the formation of palladium anion(Pd(0)^(-))intermediates.

PEG-SO_3H as an efficient and reusable catalyst for chemoselective synthesis of 1,1-diacetates

Received 20 November 2012 Received in revised form 13 December 2012 Accepted 21 December 2012 Available online 29 January 2013

Visible light promoted polyhalomethylation of alkenes: alkylation and cyclization

We report a visible light promoted carbochloromethylation of 2-bromomethyl acrylate and N-arylmethacrylamide,and a series of trihalomethyl substituted allylic acid esters and indolone derivatives were synthesized.The reaction used common and inexpensive chloroform and tribromomethane as tri-halomethyl reagents,iodobenzene diacetate(PIDA)as an oxidant and Eosin Y as a photocatalyst.The reaction conditions are mild and the substrate scope is wide.

Synthesis of N-benzothiazol-2-yl-amides by Pd-catalyzed C(sp^2)–H functionalization

A catalytic synthesis of N-benzothiazol-2-yl-amides from 1-acyl-B-（phenyl）thioureas was achieved in the presence of a palladium catalyst through the C（sp2）-H functionalization/C-S bond formation, This synthetic methodology can produce various N-benzothiazol-2-yl-amides in high yields with good functional group tolerance.

Direct amination of pyrimidin-2-yl tosylates with aqueous ammonia under metal-free and mild conditions

A metal-flee synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2- yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives.

A domino desulfitative coupling and decarboxylative coupling of 3,4-dihydropyrimidine-2-thiones with copper(Ⅰ)carboxylates

A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3,4-dihydropyrimidine-2-thiones and copper（Ⅰ） carboxylates were performed in the presence of palladium acetate.The copper（Ⅰ） carboxylates act not only as desulfurative reagents but also as sources of carbon nudeophiles.A wide array of highly substituted and functionalized pyrimidines scaffolds were synthesized in good yields.

Tunable synthesis of furfurylamines orβ-amino alcohols via Ru-catalyzed N–H functionalization using biomass-derived polyols

We report the highly efficient conversion of readily available biomass-derived polyols with amines to valuable furfurylamines orβ-amino alcohols compounds using ruthenium catalysis.The reaction outcome is readily tuned by the simple addition of 4Åmolecular sieves(furfurylamines vs.β-amino alcohols)with high chemo-selectivity.The proposed reaction mechanism involves ruthenium-catalyzed hydrogen borrowing for the reduction of the imine intermediate and C–C bond cleavage of polyols via a retro-aldol process.A series of arylamines was suc-cessfully transformed into the desired products with moderate to good yields.