目的:探讨FS-LASIK设置6.0mm和6.5mm两种光学区直径对术后视觉质量的影响。方法:本研究为前瞻性研究。选取行FS-LASIK手术的患者25例50眼,随机预设置患者双眼光学区切削直径6.0mm或6.5mm,并按光学区直径分为6.0mm及6.5mm两组。术后3mo...目的:探讨FS-LASIK设置6.0mm和6.5mm两种光学区直径对术后视觉质量的影响。方法:本研究为前瞻性研究。选取行FS-LASIK手术的患者25例50眼,随机预设置患者双眼光学区切削直径6.0mm或6.5mm,并按光学区直径分为6.0mm及6.5mm两组。术后3mo对两组患者进行Sirius三维眼前节分析系统测量角膜高阶像差(包括3、5、7mm瞳孔直径下的总高阶像差、球差、彗差及三叶草差)以及OQASⅡ视觉质量分析仪比较MTF截止空间频率(MTF cut off)、斯特列尔比值(SR)和客观散射指数(OSI)、不同模拟对比度视力(OV100%、OV20%、OV9%),并对两组患者进行OSDI干眼相关视觉质量主观问卷调查。结果:术后3mo,3mm瞳孔直径下,两组总高阶像差、球差、彗差及三叶草差无差异(均 P >0.05);5mm瞳孔直径下,两组总高阶像差、彗差、三叶草差无差异(均 P >0.05),但球差有差异( P <0.05);7mm瞳孔直径下,两组总高阶像差、球差均有差异(均 P <0.05),但彗差、三叶草差无差异(均 P >0.05)。两组的OSDI问卷评分及OQASⅡ客观视觉质量各项参数均无差异(均 P >0.05)。结论:6.5mm光学区直径FS-LASIK术后暗环境的高阶像差较小,但术前设置6.0mm光学区直径或6.5mm光学区直径均能获得良好的主观及客观视觉质量。展开更多
BACKGROUND Autoimmune enteropathy(AIE)and primary biliary cholangitis(PBC)are both immune-mediated diseases.AIE or PBC complicated with ulcerative colitis(UC)are rare.There are no cases of AIE and PBC diagnosed after ...BACKGROUND Autoimmune enteropathy(AIE)and primary biliary cholangitis(PBC)are both immune-mediated diseases.AIE or PBC complicated with ulcerative colitis(UC)are rare.There are no cases of AIE and PBC diagnosed after proctocolectomy for UC reported before,and the pathogenesis of these comorbidities has not been revealed.CASE SUMMARY A middle-aged woman diagnosed with UC underwent subtotal colectomy and ileostomy due to the steroid-resistant refractory disease,and a restorative proctectomy with ileal pouch-anal anastomosis and proximal neoileostomy was postponed due to active residual rectal inflammation in January 2016.A few months after the neoileostomy,she began to suffer from recurrent episodes of watery diarrhea.She was diagnosed with postcolectomy enteritis and stoma closure acquired a good therapeutic effect.However,her symptoms of diarrhea relapsed in 2019,with different histological features of endoscopic biopsies compared with 2016,which showed apoptotic bodies,a lack of goblet and Paneth cells,and villous blunting.A diagnosis of AIE was established,and the patient’s stool volume decreased dramatically with the treatment of methylprednisolone 60 mg/d for 1 wk and tacrolimus 3 mg/d for 4 d.Meanwhile,her constantly evaluated cholestatic enzymes and high titers of antimitochondrial antibodies indicated the diagnosis of PBC,and treatment with ursodeoxycholic acid(16 mg/kg per day)achieved satisfactory results.CONCLUSION Some immune-mediated diseases may be promoted by operation due to microbial alterations in UC patients.Continuous follow-up is essential for UC patients with postoperative complications.展开更多
AIM: To investigate and evaluate healing patterns around flaps made with different side-cut angulations after femtosecond laser in situ keratomileusis(FS-LASIK).METHODS: Thirty-four patients(68 eyes) received a 90...AIM: To investigate and evaluate healing patterns around flaps made with different side-cut angulations after femtosecond laser in situ keratomileusis(FS-LASIK).METHODS: Thirty-four patients(68 eyes) received a 90° side-cut(n=34) or a 120° side-cut flaps(n=34) made with a femtosecond laser. One day, 1 wk, 1 and 3 mo postoperatively, side-cut scar was evaluated under slit-lamp photography according to a new grading system(Grade 0=transparent scar, 1=faint healing opacity, and 2=evident healing opacity). In vivo corneal confocal microscopy and anterior segment optical coherence tomography(AS-OCT) were used to observe wound-healing patterns around flap margin in the two groups. Sirius Scheimpflug Analyzer was also used to analyze higher order aberrations 3 mo after surgery.RESULTS: There were no significant differences in flap wound-healing patterns at each follow up between the two groups(P>0.05). Three months after surgery, the flap edge scar classified as Grade 0 had excellent apposition and rapid nerve regeneration. At 3 mm and 5 mm pupil diameters, there were significant differences in trefoil aberrations between the two groups(P<0.05), but no statistically significant differences were found in total higher order aberrations(HOAs), spherical aberrations or coma in any of the pupil size conditions(P>0.05).CONCLUSION: Flap edge scars classified as Grade 0 have excellent apposition and rapid nerve regeneration, and 120° side-cut angle flaps induce less trefoil aberrations after FS-LASIK.展开更多
Background： Clarifying the risk factors for postoperative complications and taking measures to minimize these complications will improve the outcomes in patients with ulcerative colitis （UC）.This study aimed to sys...Background： Clarifying the risk factors for postoperative complications and taking measures to minimize these complications will improve the outcomes in patients with ulcerative colitis （UC）.This study aimed to systemically explore the risk factors for short-term postoperative complications in Chinese UC patients undergoing ileocolorectal surgery.Methods： Forty-nine UC patients undergoing proctocolectomy or ileostomy were retrospectively enrolled.Univariate and multivariate logistic regression analyses were conducted to reveal the risk factors among the clinical, laboratory, and surgical variables as well as preoperative medications.Results： Twenty-two （44.9%） patients who suffered from at least one short-term postoperative event had more severe hypoalbuminemia （P =0.007） and an increased prevalence of preoperative corticosteroid usage （prednisone more than 20 mg daily or equivalent） for more than 6 weeks （59.1% vs.25.9%, P =0.023） compared with patients without short-term postoperative complications.Based on the multivariate logistic regression analysis, the odds ratio （95% confidence interval） values of these two risk factors were 1.756 （0.889-3.470, P =0.105） and 3.233 （0.916-11.406, P =0.068）, respectively.In 32 severe UC patients, prolonged preoperative hospital stay worsened the short-term postoperative outcomes.Conclusions： Preoperative corticosteroids usage and hypoalbuminemia worsened the short-term outcomes following ileocolorectal surgery in Chinese UC patients.展开更多
Metal sulfide nanomaterials have attracted great interest because of their excellent properties and promising applications in sensing,energy harvesting,magnetic and optoelectronic devices,especially their well-aligned...Metal sulfide nanomaterials have attracted great interest because of their excellent properties and promising applications in sensing,energy harvesting,magnetic and optoelectronic devices,especially their well-aligned crystalline nanostructures are highly desirable for the enhanced performance and novel applications.In this study,the cobalt monosulfide(CoS)nanofibers with uniform shape and good crystallinity were firstly obtained via electrospinning and atmospheric calcination routes under controllable conditions.It was found that the CoS nanofibers exhibited ethanol sensing properties at the optimum working temperature of 200℃,the response was 11.6 toward 100×10^(-6) ethanol gas,and the CoS nanofibersbased sensor exhibits a short response time and recovery time of 5 and 6 s at the optimum temperature,respectively,the result also shows that the sensor has good stability after 50 days,which would be a favorable characteristic as a promising sensor.In addition,the Pauli paramagnetic property of CoS nanofibers was also investigated at room temperature.展开更多
To the Editor:Enteral fistula(EF)is a rare complication mostly caused by inflammatory bowel disease and in some cases by duodenal ulcer,intestinal tuberculosis,intestinal lymphoma,abdominal surgery,or necrotizing ente...To the Editor:Enteral fistula(EF)is a rare complication mostly caused by inflammatory bowel disease and in some cases by duodenal ulcer,intestinal tuberculosis,intestinal lymphoma,abdominal surgery,or necrotizing enterocolitis.[1,2]Perforative complications including perforation and EF are major complications of primary intestinal lymphoma(PIL).Vaidya et al[2]reported that in a cohort of 1062 patients with gastrointestinal lymphoma,bowel perforation occurred in 9%of the patients,and among them,the small intestine was the most common site(81%).Furthermore,perforation events occurred as the initial presentation in 51%of these patients.展开更多
文摘目的:探讨FS-LASIK设置6.0mm和6.5mm两种光学区直径对术后视觉质量的影响。方法:本研究为前瞻性研究。选取行FS-LASIK手术的患者25例50眼,随机预设置患者双眼光学区切削直径6.0mm或6.5mm,并按光学区直径分为6.0mm及6.5mm两组。术后3mo对两组患者进行Sirius三维眼前节分析系统测量角膜高阶像差(包括3、5、7mm瞳孔直径下的总高阶像差、球差、彗差及三叶草差)以及OQASⅡ视觉质量分析仪比较MTF截止空间频率(MTF cut off)、斯特列尔比值(SR)和客观散射指数(OSI)、不同模拟对比度视力(OV100%、OV20%、OV9%),并对两组患者进行OSDI干眼相关视觉质量主观问卷调查。结果:术后3mo,3mm瞳孔直径下,两组总高阶像差、球差、彗差及三叶草差无差异(均 P >0.05);5mm瞳孔直径下,两组总高阶像差、彗差、三叶草差无差异(均 P >0.05),但球差有差异( P <0.05);7mm瞳孔直径下,两组总高阶像差、球差均有差异(均 P <0.05),但彗差、三叶草差无差异(均 P >0.05)。两组的OSDI问卷评分及OQASⅡ客观视觉质量各项参数均无差异(均 P >0.05)。结论:6.5mm光学区直径FS-LASIK术后暗环境的高阶像差较小,但术前设置6.0mm光学区直径或6.5mm光学区直径均能获得良好的主观及客观视觉质量。
基金Supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS),No.2017-I2M-3-017.
文摘BACKGROUND Autoimmune enteropathy(AIE)and primary biliary cholangitis(PBC)are both immune-mediated diseases.AIE or PBC complicated with ulcerative colitis(UC)are rare.There are no cases of AIE and PBC diagnosed after proctocolectomy for UC reported before,and the pathogenesis of these comorbidities has not been revealed.CASE SUMMARY A middle-aged woman diagnosed with UC underwent subtotal colectomy and ileostomy due to the steroid-resistant refractory disease,and a restorative proctectomy with ileal pouch-anal anastomosis and proximal neoileostomy was postponed due to active residual rectal inflammation in January 2016.A few months after the neoileostomy,she began to suffer from recurrent episodes of watery diarrhea.She was diagnosed with postcolectomy enteritis and stoma closure acquired a good therapeutic effect.However,her symptoms of diarrhea relapsed in 2019,with different histological features of endoscopic biopsies compared with 2016,which showed apoptotic bodies,a lack of goblet and Paneth cells,and villous blunting.A diagnosis of AIE was established,and the patient’s stool volume decreased dramatically with the treatment of methylprednisolone 60 mg/d for 1 wk and tacrolimus 3 mg/d for 4 d.Meanwhile,her constantly evaluated cholestatic enzymes and high titers of antimitochondrial antibodies indicated the diagnosis of PBC,and treatment with ursodeoxycholic acid(16 mg/kg per day)achieved satisfactory results.CONCLUSION Some immune-mediated diseases may be promoted by operation due to microbial alterations in UC patients.Continuous follow-up is essential for UC patients with postoperative complications.
基金Supported by the Science and Technology Program of Xi’an,China No.201805097YX5SF31(2)the Foundation of Shaanxi Province Key Research and Development Project (No.2018SF-216)。
文摘AIM: To investigate and evaluate healing patterns around flaps made with different side-cut angulations after femtosecond laser in situ keratomileusis(FS-LASIK).METHODS: Thirty-four patients(68 eyes) received a 90° side-cut(n=34) or a 120° side-cut flaps(n=34) made with a femtosecond laser. One day, 1 wk, 1 and 3 mo postoperatively, side-cut scar was evaluated under slit-lamp photography according to a new grading system(Grade 0=transparent scar, 1=faint healing opacity, and 2=evident healing opacity). In vivo corneal confocal microscopy and anterior segment optical coherence tomography(AS-OCT) were used to observe wound-healing patterns around flap margin in the two groups. Sirius Scheimpflug Analyzer was also used to analyze higher order aberrations 3 mo after surgery.RESULTS: There were no significant differences in flap wound-healing patterns at each follow up between the two groups(P>0.05). Three months after surgery, the flap edge scar classified as Grade 0 had excellent apposition and rapid nerve regeneration. At 3 mm and 5 mm pupil diameters, there were significant differences in trefoil aberrations between the two groups(P<0.05), but no statistically significant differences were found in total higher order aberrations(HOAs), spherical aberrations or coma in any of the pupil size conditions(P>0.05).CONCLUSION: Flap edge scars classified as Grade 0 have excellent apposition and rapid nerve regeneration, and 120° side-cut angle flaps induce less trefoil aberrations after FS-LASIK.
文摘Background： Clarifying the risk factors for postoperative complications and taking measures to minimize these complications will improve the outcomes in patients with ulcerative colitis （UC）.This study aimed to systemically explore the risk factors for short-term postoperative complications in Chinese UC patients undergoing ileocolorectal surgery.Methods： Forty-nine UC patients undergoing proctocolectomy or ileostomy were retrospectively enrolled.Univariate and multivariate logistic regression analyses were conducted to reveal the risk factors among the clinical, laboratory, and surgical variables as well as preoperative medications.Results： Twenty-two （44.9%） patients who suffered from at least one short-term postoperative event had more severe hypoalbuminemia （P =0.007） and an increased prevalence of preoperative corticosteroid usage （prednisone more than 20 mg daily or equivalent） for more than 6 weeks （59.1% vs.25.9%, P =0.023） compared with patients without short-term postoperative complications.Based on the multivariate logistic regression analysis, the odds ratio （95% confidence interval） values of these two risk factors were 1.756 （0.889-3.470, P =0.105） and 3.233 （0.916-11.406, P =0.068）, respectively.In 32 severe UC patients, prolonged preoperative hospital stay worsened the short-term postoperative outcomes.Conclusions： Preoperative corticosteroids usage and hypoalbuminemia worsened the short-term outcomes following ileocolorectal surgery in Chinese UC patients.
基金financially supported by the National Natural Science Foundation of China(No.51227804)the Postdoctoral Scientific Research Foundation of Qingdao and National College Students Innovation and Entrepreneurship Training Program of China(No.G201911065028)College Students Innovation and Entrepreneurship Training Program of Qingdao University(No.X202011065055)。
文摘Metal sulfide nanomaterials have attracted great interest because of their excellent properties and promising applications in sensing,energy harvesting,magnetic and optoelectronic devices,especially their well-aligned crystalline nanostructures are highly desirable for the enhanced performance and novel applications.In this study,the cobalt monosulfide(CoS)nanofibers with uniform shape and good crystallinity were firstly obtained via electrospinning and atmospheric calcination routes under controllable conditions.It was found that the CoS nanofibers exhibited ethanol sensing properties at the optimum working temperature of 200℃,the response was 11.6 toward 100×10^(-6) ethanol gas,and the CoS nanofibersbased sensor exhibits a short response time and recovery time of 5 and 6 s at the optimum temperature,respectively,the result also shows that the sensor has good stability after 50 days,which would be a favorable characteristic as a promising sensor.In addition,the Pauli paramagnetic property of CoS nanofibers was also investigated at room temperature.
文摘To the Editor:Enteral fistula(EF)is a rare complication mostly caused by inflammatory bowel disease and in some cases by duodenal ulcer,intestinal tuberculosis,intestinal lymphoma,abdominal surgery,or necrotizing enterocolitis.[1,2]Perforative complications including perforation and EF are major complications of primary intestinal lymphoma(PIL).Vaidya et al[2]reported that in a cohort of 1062 patients with gastrointestinal lymphoma,bowel perforation occurred in 9%of the patients,and among them,the small intestine was the most common site(81%).Furthermore,perforation events occurred as the initial presentation in 51%of these patients.
