AIM:To elucidate the potential impact of examined lymph nodes(eLNs)on long-term survival of nodenegative gastric cancer patients after curative surgery.METHODS:A total of 497 node-negative gastric cancer patients who ...AIM:To elucidate the potential impact of examined lymph nodes(eLNs)on long-term survival of nodenegative gastric cancer patients after curative surgery.METHODS:A total of 497 node-negative gastric cancer patients who underwent curative gastrectomy between January 2000 and December 2008 in our center were enrolled in this study.Patients were divided into4 groups according to eLNs through cut-point analysis.Clinicopathological features were compared between≤15 eLNs group and>15 eLNs group and potential prognostic factors were analyzed.The Log-rank test was used to assess statistical differences between the groups.Independent prognostic factors were identifiedusing the Cox proportional hazards regression model.Stratified analysis was performed to investigate the impact of eLNs on patient survival in each stage.Overall survival was also compared among the four groups.Finally,we explored the recurrent sites associated with eLNs.RESULTS:Patients with eLNs>15 had a better survival compared with those with eLNs≤15 for the entire cohort.By the multivariate survival analysis,we found that the depth of invasion and the number of eLNs were the independent predictors of overall survival(OS)of patients with node-negative gastric cancer.According to the cut-point analysis,T2-T4 patients with 11-15 eLNs had a significantly longer mean OS than those with 4-10 eLNs or 1-3 eLNs.Patients with≤15 eLNs were more likely to experience locoregional and peritoneal recurrence than those with>15eLNs.CONCLUSION:Number of eLNs could predict the prognosis of node-negative gastric cancer,and dissection of>15 eLNs is recommended during lymphadenectomy so as to improve the long-term survival.展开更多
AIM:To assess the clinical significance of pouch size in total gastrectomy for gastric malignancies.METHODS:We manually searched the English-language literature in PubMed,Cochrane Library,Web of Science and BIOSIS Pre...AIM:To assess the clinical significance of pouch size in total gastrectomy for gastric malignancies.METHODS:We manually searched the English-language literature in PubMed,Cochrane Library,Web of Science and BIOSIS Previews up to October 31,2013.Only randomized control trials comparing small pouch with large pouch in gastric reconstruction after total gastrectomy were eligible for inclusion.Two reviewers independently carried out the literature search,study selection,data extraction and quality assessment of included publications.Standard mean difference(SMD)or relative risk(RR)and corresponding 95%CI were calculated as summary measures of effects.RESULTS:Five RCTs published between 1996 and2011 comparing small pouch formation with large pouch formation after total gastrectomy were included.Eating capacity per meal in patients with a small pouch was significantly higher than that in patients with a large pouch(SMD=0.85,95%CI:0.25-1.44,I2=0,P=0.792),and the operative time spent in the small pouch group was significantly longer than that in the large pouch group[SMD=-3.87,95%CI:-7.68-(-0.09),I2=95.6%,P=0].There were no significant differences in body weight at 3 mo(SMD=1.45,95%CI:-4.24-7.15,I2=97.7%,P=0)or 12 mo(SMD=-1.34,95%CI:-3.67-0.99,I2=94.2%,P=0)after gastrectomy,and no significant improvement of postgastrectomy symptoms(heartburn,RR=0.39,95%CI:0.12-1.29,I2=0,P=0.386;dysphagia,RR=0.86,95%CI:0.58-1.27,I2=0,P=0.435;and vomiting,RR=0.5,95%CI:0.15-1.62,I2=0,P=0.981)between the two groups.CONCLUSION:Small pouch can significantly improve the eating capacity per meal after surgery,and may improve the post-gastrectomy symptoms,including heartburn,dysphagia and vomiting.展开更多
Official Journal of Chinese Anti-Cancer AssociationDear audience,I am very glad to introduce the special issue on"Immunotherapy for lung cancer"to you.Immunotherapy has recently emerged as a promising therap...Official Journal of Chinese Anti-Cancer AssociationDear audience,I am very glad to introduce the special issue on"Immunotherapy for lung cancer"to you.Immunotherapy has recently emerged as a promising therapeutic approach for lung cancer.Clinical trials and research progress on immunotherapy for lung cancer is a spotlight in the Clinical展开更多
Indexed in PubMed/SCIE IF:4.607 Dear colleague,Cancer Biology&Medicine(CBM)(ISSN 2095-3941)is a peer-reviewed open-access journal sponsored by the China Anti-Cancer Association(CACA).Published quarterly,the journa...Indexed in PubMed/SCIE IF:4.607 Dear colleague,Cancer Biology&Medicine(CBM)(ISSN 2095-3941)is a peer-reviewed open-access journal sponsored by the China Anti-Cancer Association(CACA).Published quarterly,the journal mainly focuses on translational cancer research,dedicating to narrowing the gap between bench and bedside.展开更多
Dear audience,With the aging of population worldwide,we are faced with an increasing burden of cancer in the elderly.GLOBOCAN 2012 reported that there are 14.07 million new cancer cases worldwide every year,with 8.45 ...Dear audience,With the aging of population worldwide,we are faced with an increasing burden of cancer in the elderly.GLOBOCAN 2012 reported that there are 14.07 million new cancer cases worldwide every year,with 8.45 million patients older than 60 years.Of 8.2 million cancer deaths each year,those of patients older than 60 years are 5.7 million.According to Chinese Cancer Registry Annual Report 2014,in 2012 those aged>60 years accounted for 57.93%of all cancer patients;展开更多
基金Supported by A grant from the National Basic Research Pro-gram of China(973 Program),No.2010CB529301
文摘AIM:To elucidate the potential impact of examined lymph nodes(eLNs)on long-term survival of nodenegative gastric cancer patients after curative surgery.METHODS:A total of 497 node-negative gastric cancer patients who underwent curative gastrectomy between January 2000 and December 2008 in our center were enrolled in this study.Patients were divided into4 groups according to eLNs through cut-point analysis.Clinicopathological features were compared between≤15 eLNs group and>15 eLNs group and potential prognostic factors were analyzed.The Log-rank test was used to assess statistical differences between the groups.Independent prognostic factors were identifiedusing the Cox proportional hazards regression model.Stratified analysis was performed to investigate the impact of eLNs on patient survival in each stage.Overall survival was also compared among the four groups.Finally,we explored the recurrent sites associated with eLNs.RESULTS:Patients with eLNs>15 had a better survival compared with those with eLNs≤15 for the entire cohort.By the multivariate survival analysis,we found that the depth of invasion and the number of eLNs were the independent predictors of overall survival(OS)of patients with node-negative gastric cancer.According to the cut-point analysis,T2-T4 patients with 11-15 eLNs had a significantly longer mean OS than those with 4-10 eLNs or 1-3 eLNs.Patients with≤15 eLNs were more likely to experience locoregional and peritoneal recurrence than those with>15eLNs.CONCLUSION:Number of eLNs could predict the prognosis of node-negative gastric cancer,and dissection of>15 eLNs is recommended during lymphadenectomy so as to improve the long-term survival.
文摘AIM:To assess the clinical significance of pouch size in total gastrectomy for gastric malignancies.METHODS:We manually searched the English-language literature in PubMed,Cochrane Library,Web of Science and BIOSIS Previews up to October 31,2013.Only randomized control trials comparing small pouch with large pouch in gastric reconstruction after total gastrectomy were eligible for inclusion.Two reviewers independently carried out the literature search,study selection,data extraction and quality assessment of included publications.Standard mean difference(SMD)or relative risk(RR)and corresponding 95%CI were calculated as summary measures of effects.RESULTS:Five RCTs published between 1996 and2011 comparing small pouch formation with large pouch formation after total gastrectomy were included.Eating capacity per meal in patients with a small pouch was significantly higher than that in patients with a large pouch(SMD=0.85,95%CI:0.25-1.44,I2=0,P=0.792),and the operative time spent in the small pouch group was significantly longer than that in the large pouch group[SMD=-3.87,95%CI:-7.68-(-0.09),I2=95.6%,P=0].There were no significant differences in body weight at 3 mo(SMD=1.45,95%CI:-4.24-7.15,I2=97.7%,P=0)or 12 mo(SMD=-1.34,95%CI:-3.67-0.99,I2=94.2%,P=0)after gastrectomy,and no significant improvement of postgastrectomy symptoms(heartburn,RR=0.39,95%CI:0.12-1.29,I2=0,P=0.386;dysphagia,RR=0.86,95%CI:0.58-1.27,I2=0,P=0.435;and vomiting,RR=0.5,95%CI:0.15-1.62,I2=0,P=0.981)between the two groups.CONCLUSION:Small pouch can significantly improve the eating capacity per meal after surgery,and may improve the post-gastrectomy symptoms,including heartburn,dysphagia and vomiting.
文摘Official Journal of Chinese Anti-Cancer AssociationDear audience,I am very glad to introduce the special issue on"Immunotherapy for lung cancer"to you.Immunotherapy has recently emerged as a promising therapeutic approach for lung cancer.Clinical trials and research progress on immunotherapy for lung cancer is a spotlight in the Clinical
文摘Indexed in PubMed/SCIE IF:4.607 Dear colleague,Cancer Biology&Medicine(CBM)(ISSN 2095-3941)is a peer-reviewed open-access journal sponsored by the China Anti-Cancer Association(CACA).Published quarterly,the journal mainly focuses on translational cancer research,dedicating to narrowing the gap between bench and bedside.
文摘Dear audience,With the aging of population worldwide,we are faced with an increasing burden of cancer in the elderly.GLOBOCAN 2012 reported that there are 14.07 million new cancer cases worldwide every year,with 8.45 million patients older than 60 years.Of 8.2 million cancer deaths each year,those of patients older than 60 years are 5.7 million.According to Chinese Cancer Registry Annual Report 2014,in 2012 those aged>60 years accounted for 57.93%of all cancer patients;
