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Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid 被引量:4
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作者 xia-shi lv Yong-Mei Cui +5 位作者 He-Yun Wang Hai-Xia Lin Wei-Ya Ni Tomohiko Ohwada Katsutoshi Ido Kohei Sawada 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第11期1023-1026,共4页
A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels.The assay resul... A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels.The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at hydrazone moiety. 展开更多
关键词 BK channels Openers Dehydroabietic acid N-Acylhydrazone
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