In recent years,many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases.The Jumonji domain-containing protein D3(JMJD3),...In recent years,many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases.The Jumonji domain-containing protein D3(JMJD3),specifically demethylate di-and trimethyllysine 27 on histone H3(H3K27me2/3),has been widely studied in immune diseases,infectious diseases,cancer,developmental diseases,and aging related diseases.We will focus on the recent advances of JMJD3 function in human diseases,and looks ahead to the future of JMJD3 gene research in this review.展开更多
Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions.Different brain connection abnormalities were found to be corr...Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions.Different brain connection abnormalities were found to be correlated with various clinical manifestations,but whether a common deficit in functional connectivity(FC)in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains elusive.Objective To find a core deficit in the brain connectome that is related to both psychopathological and cognitive manifestations.Methods A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors.A principal component analysis was performed on the clinical ratings of symptom and cognition.Partial correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia patients.Results Using the principal component analysis,the first principal component(PC1)explained 37%of the total variance of seven clinical features.The ratings of GAF and BACS contributed negatively to PC1,while those of PANSS,HAMD,and HAMA contributed positively.The FCs positively correlated with PC1 mainly included connections related to the insula,precuneus gyrus,and some frontal brain regions.FCs negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital regions.Conclusion In conclusion,we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-na¨ıve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex,which may represent a core deficit of brain FC in patients with schizophrenia.展开更多
基金This work is supported by the National Natural Science Foundation of China(Grant No.81602492)the National Key Research,Development Program of China(No.2016YFA0201402)the National Major Scientific and Technological Special Project for“Significant New Drugs Development”(No.2018ZX09733001).
文摘In recent years,many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases.The Jumonji domain-containing protein D3(JMJD3),specifically demethylate di-and trimethyllysine 27 on histone H3(H3K27me2/3),has been widely studied in immune diseases,infectious diseases,cancer,developmental diseases,and aging related diseases.We will focus on the recent advances of JMJD3 function in human diseases,and looks ahead to the future of JMJD3 gene research in this review.
基金This study was supported by the National Natural Science Foundation of China(Grant Nos.8212018014,82071908,81761128023,and 82101998)Sichuan Science and Technology Program(Grant Nos.2021JDTD0002 and 2020YJ0018)+4 种基金Post-Doctor Research Project,West China Hospital,Sichuan University(Grant No.2020HXBH005)the Fundamental Research Funds for the Central Universities(Grant No.2020SCU12053)Miaozi Project in Science and Technology Innovation Program of Sichuan Province(Grant No.2021028)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Project Nos.ZYYC08001 and ZYJC18020)Dr Lui acknowledges the support from Humboldt Foundation Friedrich Wilhelm Bessel Research Award and Chang Jiang Scholars(Program No.T2019069).
文摘Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions.Different brain connection abnormalities were found to be correlated with various clinical manifestations,but whether a common deficit in functional connectivity(FC)in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains elusive.Objective To find a core deficit in the brain connectome that is related to both psychopathological and cognitive manifestations.Methods A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors.A principal component analysis was performed on the clinical ratings of symptom and cognition.Partial correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia patients.Results Using the principal component analysis,the first principal component(PC1)explained 37%of the total variance of seven clinical features.The ratings of GAF and BACS contributed negatively to PC1,while those of PANSS,HAMD,and HAMA contributed positively.The FCs positively correlated with PC1 mainly included connections related to the insula,precuneus gyrus,and some frontal brain regions.FCs negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital regions.Conclusion In conclusion,we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-na¨ıve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex,which may represent a core deficit of brain FC in patients with schizophrenia.
