Influence of transverse mode on retinal spot size and retinal injury effect:A theoreticalan alysis on 532-nm laser

The fundamental transverse mode(TEM00)is preferable for experimental and theoretical study on the laser-induced retinal injury effect,for it can produce the minimal retinal image andestablish the most strict laser safety standards.But actually lasers with higher order mode werefrequently used in both earlier and recent studies.Generally higher order mode leads to largerretinal spot size and so higher damage threshold,but there are few quantitative analyses on thisproblem.In this paper,a four-surface schematic eye model is established for human and macaque.The propagation of 532-nm laser in schematic eye is analyzed by the ABCD law of Gaussianoptics.It is shown that retinal spot size increases with laser transverse mode order.For relativelower mode order,the retinal spot diameter will not exceed the minimum laser-induced retinallesion(25~30μm in diameter),and so has little effect on retinal damage threshold.While forhigher order mode,the larger'retinal spot requires more energy to induce injury and so the damage threshold increases.When beam divergence is lowered,the retinal spot size decreasescorrespondingly,so the efect of mode order can be compensated.The retinal spot size of macaqueis slightly smaller than that of human and the ratio bet ween them is independent of mode order.We conclude that the laser mode order has significant influence on retinal spot size but limitedinfluence on the retinal injury ffect.

2019 Chinese expert consensus statement on diagnosis and treatment of syphilis

Syphilis,caused by Treponema pallidum subsp pallidum(T.pallidum),is a chronic,systemic human disease transmitted through sexual contact.The incidence and prevalence of syphilis is still high in China.[1]To guide the prevention measures and management of this disease,we renew the guidelines on diagnosis and treatment of syphilis[Supplementary file,http://links.lww.com/CM9/A292].Manifestations and diagnosis of all stages of syphilis are presented in Table 1,and management in Table 2.

National Guidelines on Diagnosis and Treatment of Gonorrhea in China (2020)

Gonorrhea is one of the main sexually transmitted diseases in China.It mainly affects the genitourinary tract,and its clinical manifestations vary from asymptomatic to complicated types.The diagnosis of gonorrhea should be based on the patient's epidemiologicai history,clinical manifestations,and laboratory examination results.Treatment should be prompt and standardized and should involve the recommended treatment regimens.Patients should be appropriately followed up after treatment.The antimicrobial resistance of gonococcal isolates has become a severe problem of clinical concern.In order to provide technical guidance of the diagnosis and treatment of gonorrhea for health care workers,the authors developed the guidelines based on the version of 2014,which will be of important in the standardizing medical care of gonorrhea,and further facilitating control and prevention of the disease.