Dear Editor,Leukemia is an important hematological malignancy characterized by uncon-trolled proliferation of hematopoietic tumor cells(Schrappe et al.,2000).It is the most common cancer in children and threatens the ...Dear Editor,Leukemia is an important hematological malignancy characterized by uncon-trolled proliferation of hematopoietic tumor cells(Schrappe et al.,2000).It is the most common cancer in children and threatens the health of adults as well.Although the treatment of leukemia has improved in recent years,the prognosis of many types of leukemia remains poor(Jarnjak-Jankovic et al.,2005).展开更多
Background:The 2014-2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease(EVD)in history.Clarifying the influence of other prevalent diseases such as human immunodeficiency virus inf...Background:The 2014-2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease(EVD)in history.Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome(HIV/AIDS)will help improve treatment and supportive care of patients with EVD.Case presentation:We examined HIV and hepatitis C virus(HCV)antibody prevalence among suspected EVD cases from the Sierra Leone-China Friendship Biological Safety Laboratory during the epidemic in Sierra Leone.HIV and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay.A high HIV prevalence(17.6%)and low HCV prevalence(0.22%)were observed among the suspected cases.Notably,we found decreased HIV positive rates among the suspected cases over the course of the epidemic.This suggests a potentially beneficial effect of an improved public health system after assistance from the World Health Organization and other international aid organizations.Conclusions:This EVD epidemic had a considerable impact on the public health system and influenced the prevalence of HIV found among suspected cases in Sierra Leone,but also provided an opportunity to establish a better surveillance network for infectious diseases.展开更多
基金This work was supported by the National Natural Science Foundation of China(Grant No.81071870)the National Basic Research Program(973 Program)(No.2011CB933504)the 111 project from the Chinese Ministry of Education.
文摘Dear Editor,Leukemia is an important hematological malignancy characterized by uncon-trolled proliferation of hematopoietic tumor cells(Schrappe et al.,2000).It is the most common cancer in children and threatens the health of adults as well.Although the treatment of leukemia has improved in recent years,the prognosis of many types of leukemia remains poor(Jarnjak-Jankovic et al.,2005).
基金the National Mega-Project for Infectious Disease,Ministry of Science and Technology(Grant no.2016ZX10004222-003)National Key Project of Ebola Research,National Natural Science Foundation of China(NSFC,Grant no.81590763)NSFC projects for Dr.William J Liu(Grant no.81373141 and 81401312).
文摘Background:The 2014-2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease(EVD)in history.Clarifying the influence of other prevalent diseases such as human immunodeficiency virus infection and acquired immune deficiency syndrome(HIV/AIDS)will help improve treatment and supportive care of patients with EVD.Case presentation:We examined HIV and hepatitis C virus(HCV)antibody prevalence among suspected EVD cases from the Sierra Leone-China Friendship Biological Safety Laboratory during the epidemic in Sierra Leone.HIV and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay.A high HIV prevalence(17.6%)and low HCV prevalence(0.22%)were observed among the suspected cases.Notably,we found decreased HIV positive rates among the suspected cases over the course of the epidemic.This suggests a potentially beneficial effect of an improved public health system after assistance from the World Health Organization and other international aid organizations.Conclusions:This EVD epidemic had a considerable impact on the public health system and influenced the prevalence of HIV found among suspected cases in Sierra Leone,but also provided an opportunity to establish a better surveillance network for infectious diseases.
