Treatment of chronic prostatitis in Chinese men

The aim of this study is to assess the status of treatment of chronic prostatitis(CP)in Chinese men.A population-based cross-sectional survey was performed,in which 15000 men aged between 15 and 60 years were randomly selected to receive a questionnaire designed to assess National Institutes of Health Chronic Prostatitis Symptoms Index(NIH-CPSI)status,therapeutic efficacy and 28 other items.A total of 12743 men(84.95%)completed the questionnaire,of whom 1071(8.4%)were identified as having prostatitis-like symptoms and 517(4.5%)were diagnosed with CP according to NIH-CPSI criteria and prostatitis-like symptomatology.Of the CP patients,372(65%)underwent long-term routine treatment 12 times per year.Additionally,217(72.8%)patients received antibiotic therapy and 215(79.3%)men showed therapeutic effects.The treatment cost USD 1151(8059 yuan)per person per year on average.Most CP patients received routine treatment,in most cases with antibiotics.Treatment was costly and most CP patients were not satisfied with its effectiveness.Antibacterial treatment might have been effective primarily in patients with bacterial disease.

Aerobic exercise improves ejaculatory behaviors and complements dapoxetine treatment by upregulating the BDNF-5-HT duo:a pilot study in rats

Accumulating evidence has revealed many clues that regular aerobic exercise benefits brain health and behaviors.The aims of this study were to explore the effect of aerobic exercise on ejaculatory behaviors,as well as to make a preliminary assessment of aerobic exercise as a complementary strategy to dapoxetine treatment in rapid ejaculators.Copulatory tests of rats and a treadmill training protocol were performed in this study.In total,12 rapid ejaculators were selected on the basis of ejaculation distribution theory and randomly assigned to 4 groups:control(Ctrol)group,aerobic exercise(Ex)group,dapoxetine(Dapo)group,and Ex+Dapo group.We evaluated the changes in ejaculatory parameters in the 4 groups.Variations in biological markers,including serum corticosterone,serotonin(5-HT),and brain-derived neurotrophic factor(BDNF)of the raphe nucleus,were determined by enzyme-linked immunosorbent assay(ELISA).The primary finding of our study was that both aerobic exercise and acute dapoxetine could enhance ejaculation control and prolong ejaculation latency in rapid ejaculator rats.The ejaculation delay effect of aerobic exercise was nearly equivalent to that of acute dapoxetine.In addition,both aerobic exercise and dapoxetine treatment could lead to increased expression of BDNF and 5-HT in the raphe nucleus of rapid ejaculators.Moreover,the two interventions,when applied together,may further upregulate the expression of BDNF-5-HT duo in a complementary manner.This study highlights the positive effects of aerobic exercise on ejaculation control.Regular aerobic exercise might be a promising complementary treatment to dapoxetine in rats.

Validity of premature ejaculation diagnostic tool and its association with International Index of Erectile Function-15 in Chinese men with evidence-based-defined premature ejaculation

早泄诊断工具(PEDT ) 是一项简短诊断措施估计早泄(PE ) 。然而，关于它在新 evidence-based-defined PE 的有效性有不够的证据。这研究被执行在 evidence-based-defined PE 的不同类型与 IIEF-15 评估 PEDT 和它的协会的有效性。从2015年6月，到2016年1月， 260 个人抱怨 PE 的一个总数和根据从 Andrology 的基于证据的定义的定义同样终生的 PE ( LPE ) /acquired PE (无尾猿)，第一的诊所加盟了医院安徽医药大学，与没有从一个体格检查中心的 PE 的 104 男健康控制一起，在这研究被注册。所有个人包括人口分布，医药、性的历史，以及 PEDT 和 IIEF-15 完成了问询表。在统计分析以后，有 PE 的人报导了更高的 PEDT 分数，这被发现(14.28 吗？

The flame retardancy of alginate/flame retardant viscose fibers investigated by vertical burning test and cone calorimeter

In this research, the flame retardancy of neat alginate fiber, flame retardant viscose fiber(FRV) and alginate/FRV(50/50) blending fibers were investigated by vertical burning and cone calorimeter tests.The vertical burning test showed that the afterflame time of alginate fiber was 0 s, but alginate presented serious smoldering behavior with the afterglow time of 605 s and damaged length of 85 mm, while the afterglow time of FRV was 0 s. When the FRV was incorporated into alginate with the weight ratio of 50/50, the afterglow time and damaged length were significantly reduced to 85 s and 35 mm, indicating the smoldering of alginate can be effectively decreased. The morphology and chemical structure of the alginate residual demonstrated that it was seriously destroyed during smoldering process, which was ascribed to its relative low initial thermal degradation temperature. Based on the thermal properties analysis, alginate and FRV fibers shared the concurrence of rapid degradation in the same temperature region of 250-300 ℃, through which, the compact and stable char formed by FRV can prevent the heat transmission and suppress the smoldering of alginate. Further, the cone calorimeter results demonstrated that the time to ignition(TTI) significantly increased and peak heat release rate(PHRR)decreased for alginate/FRV(50/50) compared with FRV. With this research, a new method to overcome the smoldering of alginate was proposed by blending with

Arabidopsis shaker pollen inward K^+ channel SPIK functions in SnRK1 complex-regulated pollen hydration on the stigma

Pollen hydration is a critical step that determines pollen germination on the stigma. KINβγ is a plantspecific subunit of the SNF1-related protein kinase 1 complex(SnRK1 complex). In pollen of the Arabidopsis kinbg mutant, the levels of reactive oxygen species were decreased which lead to compromised hydration of the mutant pollen on the stigma. In this study, we analyzed gene expression in kinβγ mutant pollen by RNA-seq and found the expression of inward shaker K^+ channel SPIK was down-regulated in the kinβγ pollen. Furthermore, we showed that the pollen hydration of the Arabidopsis spik mutant was defective on the wild-type stigma, although the mutant pollen demonstrated normal hydration in vitro.Additionally, the defective hydration of spik mutant pollen could not be rescued by the wild-type pollen on the stigma,indicating that the spik mutation deprived the capability of pollen absorption on the stigma. Our results suggest that the Arabidopsis SnRK1 complex regulates SPIK expression,which functions in determining pollen hydration on the stigma.

MBOAT1 homozygous missense variant causes nonobstructive azoospermia

Nonobstructive azoospermia(NOA)is a common cause of infertility and is defined as the complete absence of sperm in ejaculation due to defective spermatogenesis.The aim of this study was to identify the genetic etiology of NOA in an infertile male from a Chinese consanguineous family.A homozygous missense variant of the membrane-bound O-acyltransferase domain-containing 1(MBOAT1)gene(c.770C>T,p.Thr257Met)was found by whole-exome sequencing(WES).Bioinformatic analysis also showed that this variant was a pathogenic variant and that the amino acid residue in MBOAT1 was highly conserved in mammals.Quantitative polymerase chain reaction(Q-PCR)analysis showed that the mRNA level of MBOAT1 in the patient was 22.0%lower than that in his father.Furthermore,we screened variants of MBOAT1 in a broader population and found an additional homozygous variant of the MBOAT1 gene in 123 infertile men.Our data identified homozygous variants of the MBOAT1 gene associated with male infertility.This study will provide new insights for researchers to understand the molecular mechanisms of male infertility and will help clinicians make accurate diagnoses.

Towards an understanding of plant reproductive isolation:uncovering the species-specific signal for pollen tube guidance

Fertilization produces diploid zygote as the initiation of new diploid organism by fusing two haploid gametes(sperm and egg cell).Different from animals,plants in angiosperms produce immobile sperms in pollen/pollen tube(male gametophyte).Whereas,the egg cell is located in the female gametophyte(embryo sac)that consists of two female gametes(egg and central cells)and accessory cells(synergids and antipodals).Embryo sac is embedded in the ovule of ovary,which is an enlarged basal portion of the pistil.The growth of pollen tube provides a strategy for the immobile sperm approaching the egg cell.After pollination,pollen germinates at the surface of the stigma and produces pollen tube.It grows through the transmitting tract of the style and emerges from it to enter the ovary in response to certain attracting cues from the ovule.