BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with Sneddon's syndrome(SS)and cerebral venous sinus thrombosis(CVST).Particular emphasis is placed on the comprehe...BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with Sneddon's syndrome(SS)and cerebral venous sinus thrombosis(CVST).Particular emphasis is placed on the comprehensive elucidation of SS's clinical manifestations,the intricate path to diagnosis,and the exploration of potential underlying mechanisms.CASE SUMMARY A 26-year-old woman presented with recurrent episodes of paroxysmal unilateral limb weakness accompanied by skin mottling,seizures,and cognitive impairment.Digital subtraction angiography revealed CVST.Despite negative antiphospholipid antibody results,skin biopsy indicated chronic inflammatory cell infiltration.The patient was treated using anticoagulation,antiepileptic therapy,and supportive care,which resulted in symptom improvement.The coexistence of SS and CVST is rare and the underlying pathophysiology remains uncertain.This case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt intervention.CONCLUSION This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of SS with CVST and reviewed the relevant literature to improve the clinical understanding of this rare condition.展开更多
To the Editor:Membranous nephropathy(MN)is an autoimmune disease and accounts for the most common cause of nephrotic syndrome in adults.In China,the incidence of MN is estimated at approximately 12/million per year,wi...To the Editor:Membranous nephropathy(MN)is an autoimmune disease and accounts for the most common cause of nephrotic syndrome in adults.In China,the incidence of MN is estimated at approximately 12/million per year,with a mean age between 50 and 60 years and a 2:1 male predominance.MN(29.1%)was the most common pathological disease in a 10-year renal biopsy analysis.[1]In 2019,the Kidney Diseases:Improving Global Outcomes(KDIGO)guidelines recognized anti-phospholipase A2 receptor(anti-PLA2R)autoantibodies as a valuable molecular risk factor for the pejorative evolution of kidney function and recommended monitoring them for the diagnosis and assessment of MN immune activity.Assessing circulating anti-PLA2R autoantibodies may help in monitoring disease activity and guiding personalized therapy in patients with primary MN.展开更多
文摘BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with Sneddon's syndrome(SS)and cerebral venous sinus thrombosis(CVST).Particular emphasis is placed on the comprehensive elucidation of SS's clinical manifestations,the intricate path to diagnosis,and the exploration of potential underlying mechanisms.CASE SUMMARY A 26-year-old woman presented with recurrent episodes of paroxysmal unilateral limb weakness accompanied by skin mottling,seizures,and cognitive impairment.Digital subtraction angiography revealed CVST.Despite negative antiphospholipid antibody results,skin biopsy indicated chronic inflammatory cell infiltration.The patient was treated using anticoagulation,antiepileptic therapy,and supportive care,which resulted in symptom improvement.The coexistence of SS and CVST is rare and the underlying pathophysiology remains uncertain.This case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt intervention.CONCLUSION This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of SS with CVST and reviewed the relevant literature to improve the clinical understanding of this rare condition.
基金supported by grants from the“3-Year Action Plan of Shanghai to Further Speed Up the Development of Traditional Chinese Medicine”(Nos.ZY[2018-2020]-FWTX-6025,ZY[2018-2020]-ZYBZ-02).
文摘To the Editor:Membranous nephropathy(MN)is an autoimmune disease and accounts for the most common cause of nephrotic syndrome in adults.In China,the incidence of MN is estimated at approximately 12/million per year,with a mean age between 50 and 60 years and a 2:1 male predominance.MN(29.1%)was the most common pathological disease in a 10-year renal biopsy analysis.[1]In 2019,the Kidney Diseases:Improving Global Outcomes(KDIGO)guidelines recognized anti-phospholipase A2 receptor(anti-PLA2R)autoantibodies as a valuable molecular risk factor for the pejorative evolution of kidney function and recommended monitoring them for the diagnosis and assessment of MN immune activity.Assessing circulating anti-PLA2R autoantibodies may help in monitoring disease activity and guiding personalized therapy in patients with primary MN.
