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Association between HLA-DR Expression and Multidrug-resistant Infection in Patients with Severe Acute Pancreatitis 被引量:13
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作者 Zhu-xi YU xian-cheng chen +2 位作者 Bei-yuan ZHANG Ning LIU Qin GU 《Current Medical Science》 SCIE CAS 2018年第3期449-454,共6页
Multidrug-resistant (MDR) bacterial infection is a common complication of severe acute pancreatitis (SAP). This study aimed to explore the association between human leukocyte antigen-antigen D-related (HLA-DR) e... Multidrug-resistant (MDR) bacterial infection is a common complication of severe acute pancreatitis (SAP). This study aimed to explore the association between human leukocyte antigen-antigen D-related (HLA-DR) expression and multidrug-resistant infection in patients with SAP. A total of 24 SAP patients who were admitted to Nanjing Drum Tower Hospital between May 2015 and December 2016 were enrolled in the study. The percentages of CD4^+, CD8^+, natural killer (NK), and HLA-DR (CD14+) cells and the CD4^+/CD8^+ cell ratio on days 1, 7, 14, and 28 after admission were determined by flow cytometry. Eighteen patients presented with the symptoms of infection. Among them, 55.6% patients (10/18) developed MDR infection. The most common causative MDR organisms were Enterobacter cloacae and Acinetobacter baumannii. The CD4+/CD8+ cell ratio and the percentage of NK cells were similar between patients with non-MDR and patients with MDR infections. In patients without infection, the HLA-DR percentage was maintained at a high level throughout the 28 days. Compared to the patients without any infection, the HLA-DR percentage in patients with non-MDR infection was reduced on day 1 but increased and reached similar levels on day 28. In patients with MDR infection, the HLA-DR percentage remained below normal levels at all-time points. It was concluded that persistent down-regulation of HLA-DR expression is associated with MDR bacterial infection in patients with SAP. 展开更多
关键词 severe acute pancreatitis (SAP) immunomonitoring human leukocyte antigen-antigen D-related (HLA-DR) multidrug-resistant infection
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Massive pulmonary haemorrhage due to severe trauma treated with repeated alveolar lavage combined with extracorporeal membrane oxygenation:A case report 被引量:2
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作者 Bei-Yuan Zhang xian-cheng chen +2 位作者 Yong You Ming chen Wen-Kui Yu 《World Journal of Clinical Cases》 SCIE 2020年第18期4245-4251,共7页
BACKGROUND Massive pulmonary haemorrhage can spoil the entire lung and block the airway in a short period of time due to severe bleeding,which quickly leads to death.Alveolar lavage is an effective method for haemosta... BACKGROUND Massive pulmonary haemorrhage can spoil the entire lung and block the airway in a short period of time due to severe bleeding,which quickly leads to death.Alveolar lavage is an effective method for haemostasis and airway maintenance.However,patients often cannot tolerate alveolar lavage due to severe hypoxia.We used extracorporeal membrane oxygenation(ECMO)to overcome this limitation in a patient with massive pulmonary haemorrhage due to severe trauma and succeeded in saving the life by repeated alveolar lavage.CASE SUMMARY A 22-year-old man sustained multiple injuries in a motor vehicle accident and was transferred to our emergency department.On admission,he had a slight cough and a small amount of bloody sputum;computed tomography revealed multiple fractures and mild pulmonary contusion.At 37 h after admission,he developed severe chest tightness,chest pain,dizziness and haemoptysis.His oxygen saturation was 68%.Emergency endotracheal intubation was performed,and a large amount of bloody sputum was suctioned.After transfer to the intensive care unit,he developed refractory hypoxemia and heparin-free venovenous ECMO was initiated.Fibreoptic bronchoscopy revealed diffuse and profuse blood in all bronchopulmonary segment.Bleeding was observed in the trachea and right bronchus,and repeated alveolar lavage was performed.On day 3,the patient’s haemoptysis ceased,and ECMO support was terminated 10 d later.Tracheostomy was performed on day 15,and the patient was weaned from the ventilator on day 21.CONCLUSION Alveolar lavage combined with ECMO can control bleeding in trauma-induced massive pulmonary haemorrhage,is safe and can be performed bedside. 展开更多
关键词 Pulmonary contusion Massive pulmonary haemorrhage Alveolar lavage Extracorporeal membrane oxygenation Case report
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Sparganosis of the brain: a case report and brief review
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作者 Hai-Xia Li Shi-Hai Luan +7 位作者 Wei Guo Ling-Yang Hua Hong-Da Zhu Jiao-Jiao Deng Hai-Liang Tang xian-cheng chen Qing Xie Ye Gong 《Neuroimmunology and Neuroinflammation》 2017年第11期238-242,共5页
Human sparganosis is a rare disease often affecting muscle, subcutaneous tissue and other locations, but sparganosis invading the brain is rather rare. Cerebral sparganosis has no specific symptoms which makes the dia... Human sparganosis is a rare disease often affecting muscle, subcutaneous tissue and other locations, but sparganosis invading the brain is rather rare. Cerebral sparganosis has no specific symptoms which makes the diagnosis quite difficult and is usually neglected in the clinic. Here the authors reported a case of a 29-year-old female who was diagnosed with cerebral sparganosis and underwent surgery in their department and a brief review of the literature was conducted as well. 展开更多
关键词 CEREBRAL SPARGANOSIS clinical PATHOLOGICAL EPIDEMIOLOGY
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