Objective:To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.Methods:Human intestinal cancer cell HT29 xenograft of nude mice model was establi...Objective:To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.Methods:Human intestinal cancer cell HT29 xenograft of nude mice model was established.The expression of ECF,VEGF,gastric cancer tumor growth in mice were observed.Results:Protein kinase C expression in in the Yiqi Jianpi group and Yiqi Jianpi anti-tumor group was significantly better than the model group(P<0.01,P<0.05).There was significantly more apoptotic cells in Yiqi Jianpi anti-tumor group than Yiqi Jianpi group and model group(P<0.01).Epidermal growth factor and vascular endothelial growth factor expression in Yiqi Jianpi group was significantly lower than Yiqi Jianpi group and model group(P<0.05).Conclusions:Tumor can inhibit the expression of PKC inhibition.Yiqi Jianpi and anticancer treatment can reduce this inhibition.Besides this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothelial growth factor.展开更多
According to the International Continence Society,stress urinary incontinence(SUI)was defined as involuntary leakage on effort or exertion,or on sneezing or coughing.The prevalence of SUI varies among different age gr...According to the International Continence Society,stress urinary incontinence(SUI)was defined as involuntary leakage on effort or exertion,or on sneezing or coughing.The prevalence of SUI varies among different age groups and is reportedly 48%(29%-75%).⑴The mid-urethral sling(MUS)procedure is currently considered the gold standard in the surgical treatment of SUL The long-term cure rate of SUI using MUS ranges from 76.9%to 90.0%.11,21 However,incontinence persists in approximately 20%of SUI patients who underwent MUS procedure,and they require further treatment.展开更多
Censored regression("Tobit") model is a special case of limited dependent variable regression model, and plays an important role in econometrics. Based on this model, all kinds of methods for variable or gro...Censored regression("Tobit") model is a special case of limited dependent variable regression model, and plays an important role in econometrics. Based on this model, all kinds of methods for variable or group variable selection have been developed and the corresponding shrinkage parameter estimates are widely studied. However, asymptotic distributions of the shrinkage estimates involve unknown nuisance parameters,such as density function of error term. To avoid estimating nuisance parameters, this paper presents a randomly weighting method to approximate to the asymptotic distribution of the shrinkage estimate. A computation procedure of random approximation is provided and asymptotic properties of the randomly weighting estimates are also obtained. The proposed methods are evaluated with extensively numerical studies and a women labor supply example.展开更多
基金supported by Fund of Administration Bureau of TCM(2012727632)
文摘Objective:To observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.Methods:Human intestinal cancer cell HT29 xenograft of nude mice model was established.The expression of ECF,VEGF,gastric cancer tumor growth in mice were observed.Results:Protein kinase C expression in in the Yiqi Jianpi group and Yiqi Jianpi anti-tumor group was significantly better than the model group(P<0.01,P<0.05).There was significantly more apoptotic cells in Yiqi Jianpi anti-tumor group than Yiqi Jianpi group and model group(P<0.01).Epidermal growth factor and vascular endothelial growth factor expression in Yiqi Jianpi group was significantly lower than Yiqi Jianpi group and model group(P<0.05).Conclusions:Tumor can inhibit the expression of PKC inhibition.Yiqi Jianpi and anticancer treatment can reduce this inhibition.Besides this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothelial growth factor.
文摘According to the International Continence Society,stress urinary incontinence(SUI)was defined as involuntary leakage on effort or exertion,or on sneezing or coughing.The prevalence of SUI varies among different age groups and is reportedly 48%(29%-75%).⑴The mid-urethral sling(MUS)procedure is currently considered the gold standard in the surgical treatment of SUL The long-term cure rate of SUI using MUS ranges from 76.9%to 90.0%.11,21 However,incontinence persists in approximately 20%of SUI patients who underwent MUS procedure,and they require further treatment.
基金partially supported by National Natural Science Foundation of China(Grant No.11101396)Anhui Provincial Natural Science Foundation(Grant No.1908085MA06)
文摘Censored regression("Tobit") model is a special case of limited dependent variable regression model, and plays an important role in econometrics. Based on this model, all kinds of methods for variable or group variable selection have been developed and the corresponding shrinkage parameter estimates are widely studied. However, asymptotic distributions of the shrinkage estimates involve unknown nuisance parameters,such as density function of error term. To avoid estimating nuisance parameters, this paper presents a randomly weighting method to approximate to the asymptotic distribution of the shrinkage estimate. A computation procedure of random approximation is provided and asymptotic properties of the randomly weighting estimates are also obtained. The proposed methods are evaluated with extensively numerical studies and a women labor supply example.
