Dynamic microphysiological system chip platform for high-throughput,customizable,and multi-dimensional drug screening

Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening.By employing diverse types of spheroids or organoids,it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug screening.High-throughput microphysiological systems that support optional,parallel testing of multiple drugs have promising applications in personalized medical treatment and drug research.However,establishing such a system is highly challenging and requires a multidisciplinary approach.This study introduces a dynamic Microphysiological System Chip Platform(MSCP)with multiple functional microstructures that encompass the mentioned advantages.We developed a high-throughput lung cancer spheroids model and an intestine-liverheart-lung cancer microphysiological system for conducting parallel testing on four anti-lung cancer drugs,demonstrating the feasibility of the MSCP.This microphysiological system combines microscale and macroscale biomimetics to enable a comprehensive assessment of drug efficacy and side effects.Moreover,the microphysiological system enables evaluation of the real pharmacological effect of drug molecules reaching the target lesion after absorption by normal organs through fluid-based physiological communication.The MSCP could serves as a valuable platform for microphysiological system research,making significant contributions to disease modeling,drug development,and personalized medical treatment.

Elastic and Stretchable Functional Fibers: A Review of Materials, Fabrication Methods, and Applications

Elastic and stretchable functional fibers have drawn attentions from wide research field because of their unique advantages including high dynamic bending elasticity,stretchability and high mechanic strength.Lots of efforts have been made to find promising soft materials and improve the processing methods to fabricate the elastomer fibers with controllable fiber geometries and designable functionalities.Significant progress has been made and various interdisciplinary applications have been demonstrated based on their unique mechanical performance.A series of remarkable applications,involving biomedicine,optics,electronics,human machine interfaces etc.,have been successfully achieved.Here,we summarize main processing methods to fabricate soft and stretchable functional fibers using different types of elastic materials,which are either widely used or specifically developed.We also introduce some representative applications of multifunctional elastic fibers to reveal this promising research area.All these reported applications indicate that the fast innovated interdisciplinary area is of great potential and inspire more remarkable ideas in fiber sensing,soft electronics,functional fiber integration and other related research fields.

Oxygen-assisted preparation of mechanoluminescent ZnS：Mn for dynamic pressure mapping

Mechanoluminescent materials that convert mechanical stimuli to light emission have attracted extensive attention for potential applications in human-machine interactions. Here, we report a simple and available novel approach for the oxygen-assisted preparation of ZnS：Mn particles by solid-state reaction at atmospheric pressure without the formation of the corresponding oxides. The existence of O2 has a positive impact on the formation of S vacancies in wurtzite-phase ZnS, leading to the introduction of Mn2＋ ion luminescent centers and shallow donor levels, which can improve the electron-hole recombination rate. The O2 ratio and Mn2＋ ion doping concentration have significant effects on the luminous efficienc）5 which is optimal at 1%-20% and 1 at.%-2 at.% respectively. In addition, a device based on the piezo-photonic effect with excellent pressure sensitivity of 0.032 MPa-1 was fabricated, which can map the two-dimensional pressure distribution ranging from 2.2 to 40.6 MPa in situ. This device can be applied to real-time pressure mapping, smart sensor networks, high-level security systems, human-machine interfaces, and artificial skins.