一种基于分压电路的绑定后TSV测试方法

对硅通孔(Through Silicon Via,TSV)进行绑定后测试可以有效地提升三维集成电路的性能和良率。现有的测试方法虽然对于开路和桥接故障的测试能力较高,但是对于泄漏故障的测试效果较差,并且所需的总测试时间较长。对此,提出了一种基于分压电路的TSV绑定后测试方法。该方法设计了一种分压电路,进行泄漏故障测试时可以形成一条无分支的电流路径,有效提高了对泄漏故障的测试能力。此外,该方法测试开路故障和泄漏故障时的电流路径不会相互干扰,可以同时测试相邻TSV的开路故障和泄漏故障。实验结果表明,该方法可以测试10 kΩ以下的弱泄漏故障,并且在工艺偏差下依然能够保持较高的测试能力。相比同类测试方法,该方法所需面积开销更小,所需总测试时间更少。

DRG付费下重点稽核违规行为智能审核和监控规则库比较研究

目的通过对重点稽核违规行为智能审核和监控规则库进行规则类别、重点稽核行为、规则与行为对应程度比较分析,为完善我国DRG付费下医保重点稽核违规行为智能审核和监控提供参考。方法检索收集2019年5月20日—2023年12月31日各地医保局发布的DRG付费管理办法等政策文件及数据库中DRG付费智能审核监控规则的相关文献,针对其中与DRG付费下重点稽核违规行为相关的规则,采用文献分析法和比较分析法进行归纳和分析。结果DRG付费下重点稽核违规行为智能审核规则可分为逻辑判断类和参数指标类两大类,审核规则与重点稽核行为的对应程度各异。结论(1)统一全国重点稽核规则,保证规则的普适性、全面性;(2)深挖区域违规行为现状,强化地方特色;(3)逻辑判断类规则“提质”与参数指标类规则“增量”共进;(4)强化新型违规行为的科学研究,建立更具针对性的监管规则。

CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease

Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's disease.FIFO-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy metabolism.However,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea r.Therefore,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of PD.We found that CHCHD2 protected mitochondria from developing MPP^(+)-induced dysfunction.Under normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase assembly.In addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and F1FO-ATPase.Three weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this model.These findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function.

Probing the electric double layer structure at nitrogen-doped graphite electrodes by constant-potential molecular dynamics simulations

Electric double layer(EDL)is a critical topic in electrochemistry and largely determines the working performance of lithium batteries.However,atomic insights into the EDL structures on heteroatom-modified graphite anodes and EDL evolution with electrode potential are very lacking.Herein,a constant-potential molecular dynamics(CPMD)method is proposed to probe the EDL structure under working conditions,taking N-doped graphite electrodes and carbonate electrolytes as an example.An interface model was developed,incorporating the electrode potential and atom electronegativities.As a result,an insightful atomic scenario for the EDL structure under varied electrode potentials has been established,which unveils the important role of doping sites in regulating both the EDL structures and the following electrochemical reactions at the atomic level.Specifically,the negatively charged N atoms repel the anions and adsorb Li~+at high and low potentials,respectively.Such preferential adsorption suggests that Ndoped graphite can promote Li~+desolvation and regulate the location of Li~+deposition.This CPMD method not only unveils the mysterious function of N-doping from the viewpoint of EDL at the atomic level but also applies to probe the interfacial structure on other complicated electrodes.

Betaine addition to the diet alleviates intestinal injury in growing rabbits during the summer heat through the AAT/mTOR pathway

Background The aim of this experiment was to investigate the effect of different levels of betaine(Bet)inclusion in the diet on the intestinal health of growing rabbits under summer heat.A total of 100 weaned Qixing meat rabbits aged 35 d with body weight of 748.61±38.59 g were randomly divided into 5 treatment groups:control group(basal diet)and Bet groups(basal diet+0.75,1.0,1.5 or 2.0 g/kg Bet).The average daily temperature in the rabbitry during the experiment was 30.48°C and the relative humidity was 69.44%.Results Dietary addition of Bet had no significant effect on growth performance and health status of growing rabbits(P>0.05),but it increased ileal secretory immunoglobulin A content compared to the control under summer heat(P<0.05).Addition of 0.75 g/kg Bet up-regulated jejunal IL-4,down-regulated ileal TNF-αexpression(P<0.05).The addition of 1.0 g/kg Bet increased the villi height(VH)in the jejunum(P<0.05).Serum glucose levels were reduced,and the expression of SLC6A20 was up-regulated in jejunum and ileum of rabbits fed with 1.5 g/kg Bet(P<0.05).When added at 2.0 g/kg,Bet reduced serum HSP70 content,increased jejunal VH,and up-regulated duodenal SLC7A6,SLC38A2,mTOR and 4EBP-2 expression(P<0.05).Correlation analysis revealed that intestinal mTOR expression was significantly and positively correlated with SLC7A6,SLC38A2,SLC36A1 and IL-4 expression(P<0.05).Conclusions Dietary addition of Bet can up-regulate the expression of anti-inflammatory factors through the AAT/mTOR pathway,improve the intestinal immune function,alleviate intestinal damage in growing rabbits caused by summer heat,and improve intestinal health.

Microstructure and mechanical properties of a cast TRIP-assisted multiphase stainless steel

Stainless steels are used in a wide range of complex environments due to their excellent corrosion resistance.Multiphase stainless steels can offer an excellent combination of strength,toughness and corrosion resistance due to the coexistence of different microstructures.The microstructure and mechanical properties of a novel cast multiphase stainless steel,composed of martensite,ferrite,and austenite,were investigated following appropriate heat treatment processes:solution treatment at 1,050℃ for 0.5 h followed by water quenching to room temperature,and aging treatment at 500℃ for 4 h followed by water quenching to room temperature.Results show reversed austenite is formed by diffusion of Ni element during aging process,and the enrichment of Ni atoms directly determines the mechanical stability of austenite.The austenite with a lower Ni content undergoes a martensitic transformation during plastic deformation.The tensile strength of the specimen exceeds 1,100 MPa and the elongation exceeds 24%after solid solution,and further increases to 1,247 MPa and 25%after aging treatment.This enhancement is due to the TRIP effect of austenite and the precipitation of the nanoscale G-phase pinning dislocations in ferrite and martensite.

Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties

The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake discs.In this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical properties.Compacted graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of ferrite.The peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction tests.The morphology of thermal cracks and 3D profiles of the worn surfaces were also discussed.It is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue resistance.Oxidization of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal cracks.Despite the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear.

基于PMC指数模型的我国医疗保障基金使用监管政策文本量化评价

医疗保障基金使用监管需要有效的政策体系支持,政策文本量化评价可以为相应政策的制定与完善提供依据,但目前相关研究尚不多见。以国家层面出台的54项医疗保障基金使用监管政策为研究对象,在对政策文本进行内容挖掘的基础上,借鉴已有学者相关研究构建PMC指数模型,进而对筛选的国家医疗保障局成立后颁布的13项医疗保障基金使用监管专项政策文本进行量化评价,研究发现,13项专项政策的PMC指数均值为5.80,3项政策等级为优秀,10项为良好,表明国家层面的医疗保障基金使用监管专项政策的质量总体较好,但部分政策存在预测和支持作用不足、受体缺位、激励约束不完善和内容不全面的问题。建议通过增强政策的预测性和支持性,适当拓展政策受体范围,增加有关规范医疗行为、加强人才队伍建设和监管绩效考核的内容,科学制定和完善医疗保障基金使用监管政策。

可见光诱导Z型V_(2)O_(5)/g-C_(3)N_(4)异质结催化未活化烯烃串联反应

半导体光催化剂是一种极具前景的绿色催化剂,广泛用于污染物降解、水解制氢和有机合成等领域,有望利用太阳能来解决能源和环境问题,是当前的研究前沿和热点.然而,单组分半导体光催化剂的光生电子和空穴容易复合,导致量子效率差和光催化效率低.近年人们发现,将两种或多种催化材料结合,构建异质结光催化体系可有效促进光生电子-空穴分离.但传统的异质结体系中光生电子的还原性和光生空穴的氧化性通常在电荷转移后变弱,因此,很难同时具备高电荷转移效率和强氧化还原能力.研究发现,构建Z型异质结光催化体系不仅可以减少本体电子-空穴的复合,使其在不同半导体材料上实现空间分离,具有光谱响应宽、电荷分离效率高和稳定性高等优势,而且能保持良好的氧化还原能力.在半导体材料领域,石墨相氮化碳(g-C_(3)N_(4))作为一种无金属聚合物半导体,具有良好的热化学稳定性、电学和光学特性,但存在量子效率低和适用范围窄等局限性.而五氧化二钒(V_(2)O_(5))是一种重要的过渡金属氧化物半导体,由于具有良好的电学和光学性能被广泛用于锂离子电池、气敏传感器和光电器件.V_(2)O_(5)能带间隙(~2.19 e V)窄,具有合适的能量频带边缘(ECB=0.81 e V,EVB=3.0 e V),可以与g-C_(3)N_(4)(ECB=1.14 e V,EVB=1.59 e V)很好地匹配,形成稳定状态的Z型光催化体系,并提高光催化有机合成反应的效率.本文以三聚氰胺和偏钒酸铵为原料,采用热处理法分别制备g-C_(3)N_(4)和V_(2)O_(5),采用水热法制备Z型V_(2)O_(5)/g-C_(3)N_(4)二元复合材料.X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)、扫描电子显微镜(SEM)、X射线光电子能谱(XPS)和紫外-可见光吸收光谱(UV-Vis)等结果表明,成功制备了Z型V_(2)O_(5)/g-C_(3)N_(4).UV-Vis结果表明,V_(2)O_(5)/g-C_(3)N_(4)具有较宽的光吸收范围,从而提高了复合半导体材料的光学性能.在温和条件下,以未活化烯烃修饰的喹唑啉酮和芳基氧膦为反应物,V_(2)O_(5)/g-C_(3)N_(4)为多相光催化剂,进行膦酰化自由基偶联反应,制得一系列环合的膦酰化喹唑啉酮,收率为63%-83%.该反应具有原料易得、条件温和、底物范围广、产品收率及区域选择性良好等优点,同时催化剂循环使用性能良好.值得注意的是,不同吸电子取代基、供电子取代基修饰的喹唑啉酮和非对称结构的芳基氧膦均能兼容于该反应体系,并以中等至良好的收率得到了各种膦酰化喹唑啉酮化合物.本文采用的合成策略同样适用于三氟甲基化、二氟烷基化和芳基磺酰化等自由基串联环化反应,且具有良好的催化性能.机理研究结果表明,V_(2)O_(5)/g-C_(3)N_(4)被光激发后,V_(2)O_(5)导带(CB)上的光生电子与g-C_(3)N_(4)价带(VB)上的光生空穴迅速复合,导致g-C_(3)N_(4)的导带上无法与本体空穴复合的电子发生单电子转移(SET)过程,且与分子氧(空气中)反应生成超氧阴离子自由基(O_(2)·^(-)).V_(2)O_(5)价带上的空穴氧化芳基氧膦产生自由基阳离子,去质子化产生氧膦自由基,随后加成到未活化烯烃生成新的自由基物种,最后发生分子内环化反应,得到目标产物.V_(2)O_(5)/g-C_(3)N_(4)成本较低,且该光催化反应策略可实现克级制备,循环使用5次后催化活性保持不变.综上,本文可为光催化自由基串联环化反应,杂环化合物合成研究和Z型异质结的光催化应用提供参考.

老年干眼患者的发病危险因素及中医证候分析

目的探讨老年干眼患者的发病危险因素及中医证候类型,为临床老年干眼的预防、诊断及治疗提供参考。方法选取2021年12月至2022年12月于湖南中医药大学第一附属医院眼科就诊的72例老年患者为研究对象,根据是否诊断为干眼将患者分为病例组(38例)和对照组(34例)。收集两组患者的临床资料,采用多因素Logistic回归分析探讨老年干眼发病的影响因素。结果两组患者的性别、是否屈光不正、是否有眼表疾病史、是否易失眠比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,有屈光不正、有眼表疾病史、易失眠均是老年干眼患病的危险因素(P<0.05)。老年干眼的中医证型以肝肾阴虚证最为常见。结论屈光不正、眼表疾病史、易失眠均是老年干眼患病的危险因素,以肝肾阴虚证型最为常见。

Late spring cold reduces grain number at various spike positions by regulating spike growth and assimilate distribution in winter wheat

Late spring cold(LSC) occurred in the reproductive period of wheat impairs spike and floret differentiation during the reproductive period,when young spikelets are very cold-sensitive.However,under LSC,the responses of wheat spikelets at various positions,leaves,and stems and the interactions between them at physiological levels remain unclear.In the present study,two-year treatments at terminal spikelet stage under two temperatures(2 C,-2 C) and durations(1,2,and 3 days) were imposed in an artificial climate chamber to compare the effects of LSC on grain number and yield in the wheat cultivars Yannong 19(YN19,cold-tolerant) and Xinmai 26(XM26,cold-sensitive).The night temperature regimes were designed to reproduce natural temperature variation.LSC delayed plant growth and inhibited spike and floret differentiation,leading to high yield losses in both cultivars.LSC reduced dry matter accumulation(DMA,g) in spikes,stems,and leaves,reducing the DMA ratios of the spike to leaf and spike to stem.Plant cell wall invertase(CWINV) activity increased in upper and basal spikelets in YN19,whereas CWINV increased in middle spikelets in XM26.Under LSC,soluble sugar and glucose were transported and distributed mainly in upper and basal spikelets for glume and rachis development,so that spike development was relatively complete in YN19,whereas the upper and basal spikelets were severely damaged and most of the glumes in middle spikelets were relatively completely developed in XM26,resulting in pollen abortion mainly in upper and basal spikelets.The development of glumes and rachides was influenced and grain number per spike was decreased after LSC,with kernels present mainly in middle spikelets.Overall,reduced total DMA and dry matter partitioning to spikes under LSC results in poor spikelet development,leading to high losses of grain yield.

Super-exchange effect induced by early 3d metal doping on NiFe_(2)O_(4)(001)surface for oxygen evolution reaction

Understanding the intrinsic activity of oxygen evolution reaction(OER) is crucial for catalyst design.To date,different metal-doping strategies have been developed to achieve this,but the involving mechanisms remain unclear.Here,the electronic structure of the transition metal-doped NiFe_(2)O_(4)(001) surface is scrutinized for OER intrinsic activity using density functional theory calculations.Five 3d-orbital filling metals(Ti,V,Cr,Mn,and Co) are introduced as dopants onto A-and B-layers of the NiFe_(2)O_(4)(001) surface,and variation of oxidation states over Fe sites is observed on B-layer.Analyzing the magnetic moment and charge transfer of surface cation sites reveals that the variation of Fe oxidation states originates from the super-exchange effect and is influenced by the t2g-electron configuration of 3d metal dopants.This trend governs the generation of highly-active Fe3+sites on the B-layer,the adsorption strength of OER intermediates,i.e.,*O and*OH,and therefore the intrinsic activity.The finding of super-exchange mechanism induced by 3d early metal doping offers insights into electronic structure tailoring strategies for improving the intrinsic activity of OER electrocatalysts.

Fault rupture propagation in soil with intercalation using nonlocal model and softening modulus modification

Fault rupture propagation is more complex in the overlying soil with intercalation than in homogeneous soil,and it is challenging to simulate this phenomenon accurately using the finite element method.To address this issue,an improved nonlocal model that incorporates softening modulus modification is proposed.The methodology has the advantage that the solutions are independent of both mesh sizes and characteristic lengths,while maintaining objective softening rates of materials.Using the proposed methodology,a series of numerical simulations are conducted to investigate the effects of different mechanical parameters,such as elastic modulus,friction angle and dilation angle of the soil within the intercalation,as well as the impact of geometries,such as the depth and thickness of the intercalation,on the fault rupture progress.This study not only provides significant insights into the mechanisms of fault rupture propagation,specifically in relation to intercalations,but also shows a great value in promoting the current research on fault rupture.

Probing nucleon effective mass splitting with light particle emission

The main objective of this study was to investigate the impact of effective mass splitting on heavy-ion-collision observables.We first analyzed correlations between different nuclear matter parameters obtained from 119 effective Skyrme interaction sets.The values of the correlation coefficients illustrate that the magnitude of effective mass splitting is crucial for tight constraints on the symmetry energy via heavy-ion collisions.The^(86)Kr+^(208)Pb system at beam energies ranging from 25 to 200A MeV was simulated within the framework of the improved quantum molecular dynamics model(ImQMD-Sky).Our calculations show that the slopes of the spectra of ln[Y(n)/Y(p)]and ln[Y(t)/Y(^(3)He)],which are the logarithms of the neutron to proton and triton to helium-3 yield ratios,are directly related to effective mass splitting and can be used to probe the effective mass splitting.

Clinical study of NFNC in the treatment of acute exacerbation chronic obstructive pulmonary disease patients with respiratory failure

BACKGROUND Most patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD)have respiratory failure that necessitates active correction and the improvement of oxygenation is particularly important during treatment.High flow nasal cannula(HFNC)oxygen therapy is a non-invasive respiratory aid that is widely used in the clinic that improves oxygenation state,reduces dead space ventilation and breathing effort,protects the loss of cilia in the airways,and improves patient comfort.AIM To compare HFNC and non-invasive positive pressure ventilation in the treatment of patients with AECOPD.METHODS Eighty AECOPD patients were included in the study.The patients were in the intensive care department of our hospital from October 2019 to October 2021.The patients were divided into the control and treatment groups according to the different treatment methods with 40 patients in each group.Differences in patient comfort,blood gas analysis and infection indices were analyzed between the two groups.RESULTS After treatment,symptoms including nasal,throat and chest discomfort were significantly lower in the treatment group compared to the control group on the 3rd and 5th days(P<0.05).Before treatment,the PaO_(2),PaO_(2)/FiO_(2),PaCO_(2),and SaO_(2)in the two groups of patients were not significantly different(P>0.05).After treatment,the same indicators were significantly improved in both patient groups but had improved more in the treatment group compared to the control group(P<0.05).After treatment,the white blood cell count,and the levels of C-reactive protein and calcitonin in patients in the treatment group were significantly higher compared to patients in the control group(P<0.05).CONCLUSION HFNC treatment can improve the ventilation of AECOPD patients whilst also improving patient comfort,and reducing complications.HFNC is a clinically valuable technique for the treatment of AECOPD.

藤黄健骨胶囊联合西药治疗骨质疏松症Meta分析

目的 对藤黄健骨胶囊治疗骨质疏松症(Osteoporosis,OP)的有效性及安全性进行系统评价和Meta分析。方法 通过中国维普、知网、万方及外文数据库PubMed检索从建库—2023年1月的文献,查找藤黄健骨胶囊治疗OP的随机对照试验。对纳入的文献进行数据提取及方法学质量评价,采用Revman 5.3软件进行Meta分析。结果 最终纳入7篇文献结论,共纳入7项随机对照试验。Meta分析结果显示:治疗有效率[RR=1.22,95%CI(1.12,1.32),P<0.000 01],腰椎骨密度[MD=0.06,95%CI(0.04,0.08),P<0.000 01]、股骨颈骨密度[MD=0.07,95%CI(0.05,0.08),P<0.000 01]、Ward三角骨密度[MD=0.08,95%CI(0.06,0.10),P<0.000 01]、VAS评分[MD=-1.27,95%CI(-1.41,-1.133),P<0.000 01],不良反应发生率[RR=0.42,95%CI(0.15,1.13),P=0.09]。结论 藤黄健骨胶囊联合西药治疗OP能更有效地缓解患者疼痛,提高治疗有效率,提高患者骨密度,且安全性好。但本研究结果仍需更多双盲、多样本、多中心的研究来进一步证实。

熔融铝对Al活化TiO_2的反应自发渗透（英文）

研究Al活化TiO_2(锐钛矿型)的反应自发渗透。为了进行活化,先将纯Al粉与TiO_2混合,再将其压制成预制棒,然后密封于6060铝合金模具中。活化和渗透试验在6060铝合金浴中完成,时间1h。作为对比,在相同的温度和时间条件下,在氩气保护环境中进行烧结试验。X射线衍射分析表明,就Al与TiO_2的反应活化而言,Al密封环境优于氩气保护。试验发现,TiO_2与Al的混合比和温度影响渗透和反应动力学,在渗透过程中起着主要的作用。渗透后观察到3种主要的显微结构:完全渗透、部分渗透并形成裂纹和无渗透。基于反应动力学和反应导致的局部体积变化,解释这些显微结构的形成原因。最后,研究发现,为了获得总体良好的自发渗透,TiO_2与Al混合比(体积比)约3:7、渗透温度约900°C最为适宜。

EZH2抑制剂对膀胱癌T24细胞上皮间质转化的影响及其机制研究

目的探讨Zeste基因增强子同源物2(EZH2)抑制剂对膀胱癌T24细胞上皮间质转化(EMT)的影响及其作用机制。方法取对数生长期T24细胞,随机分为空白组、GSK126低剂量组、GSK126中剂量组、GSK126高剂量组,每组设置5个复孔,分别用终浓度为0μmol/L、10μmol/L、20μmol/L、40μmol/L的GSK126细胞培养基培养。采用MTT法检测培养24 h、48 h、72 h细胞增殖能力,Transwell法和划痕实验检测培养48 h细胞侵袭和迁移能力,qRT-PCR和Western blotting检测培养48 h细胞中上皮间质标志物E-cadherin、Vimentin、β-catenin及EZH2 mRNA和蛋白相对表达量。结果空白组及GSK126低、中、高剂量组细胞培养24 h、48 h、72 h的增殖能力比较,采用重复测量设计的方差分析,结果:①不同时间细胞增殖能力有差异(F=15.498,P=0.000);②4组细胞增殖能力有差异(F=5.162,P=0.013);③4组细胞增殖能力变化趋势有差异(F=12.314,P=0.000)。与空白组比较,GSK126低、中、高剂量组穿膜细胞数、迁移率,以及EZH2、Vimentin、β-catenin mRNA和蛋白相对表达量均降低(P<0.05),且随GSK126剂量升高而降低(P<0.05)。与空白组比较,GSK126低、中、高剂量组E-cadherin mRNA和蛋白相对表达量均升高(P<0.05),且随GSK126剂量升高而升高(P<0.05)。与空白组比较,GSK126低、中、高剂量组p-JAK2/JAK2、p-STAT3/STAT3蛋白相对表达量均降低(P<0.05),且随GSK126剂量升高而降低(P<0.05)。结论EZH2抑制剂可有效抑制膀胱癌T24细胞EMT,其调控机制可能与抑制JAK2/STAT3信号通路中JAK2和STAT3蛋白磷酸化有关。

Optimization of the Impeller Geometry for an Automotive Torque Converter Using Response Surface Methodology and Desirability Function

Response surface methodology (RSM) based on desirability function approach (DFA) is applied to obtain an optimal design of the impeller geometry for an automotive torque converter. The relative importance of six design parameters including impeller blade number, blade thickness, bias angle, scroll angle, inlet angle and exit angle is investigated using orthogonal design approach. The impeller inlet angle, exit angle and bias angle are found to exert the greatest influence on the overall performance of a torque converter, with two flow area factors being considered, namely 17% and 20%. Then, RSM together with central composite design (CCD) method is used to in-depth evaluate the interaction effect of the three key parameters on converter performance. The results demonstrate that impeller exit angle has the strongest impact on peak efficiency, with larger angles yielding the most favorable results. The stall torque ratio maximization is attainable with the increase of impeller bias angle and inlet angle together with smaller exit angle. In the end, an optimized design for the impeller geometry is obtained with stall torque ratio and peak efficiency increased by 1.62% and 1.1%, respectively. The new optimization method can be used as a reference for performance enhancement in the design process of impeller geometry for an automotive torque converter.

累积挤压工艺制备纯铝的晶粒细化及力学性能（英文）

研究一种新的剧烈塑性变形技术,即累积挤压结合(AEB)加工超细晶粒铝。显微组织表征结果表明,界面结合良好,6道次后样品的平均晶粒尺寸约为440 nm。拉伸试验结果表明,5道次后样品的抗拉强度达到最大值195 MPa,总伸长率超过16%;样品的硬度也显著提高,且在第1道次后几乎达到饱和。累积挤压加工的样品经拉伸试验后的扫描电镜断口形貌表明,断裂模式为剪切韧性断裂,同时出现细长浅韧窝。与传统累积叠轧工艺相比,此新型累积挤压技术在细化晶粒和改善力学性能方面更有效。