Quantum many-body systems in which time-reversal symmetry is broken give rise to a wealth of exotic phases,and thus constitute one of the frontiers of modern condensed matter physics.Quantum simulation allows us to be...Quantum many-body systems in which time-reversal symmetry is broken give rise to a wealth of exotic phases,and thus constitute one of the frontiers of modern condensed matter physics.Quantum simulation allows us to better understand many-body systems with huge Hilbert space,where classical simulation is usually inefficient.With superconducting quantum circuit as a platform for quantum simulation,we realize synthetic Abelian gauge fields by using microwave drive and tunable coupling in loop configurations to break the time-reversal symmetry of the system.Based on high-precision manipulation and readout of circuit-QED architecture,we demonstrate the chiral ground spin current of a time-reversal symmetry broken system with nontrivial interactions.Our work is a significant attempt to simulate quantum many-body systems with time-reversal symmetry breaking in multi-qubit superconducting processors.展开更多
Accuracy validation is essential to clinical application of medical image registration techniques. Registration validation remains a challenging problem in practice mainly due to lack of 'ground truth'. In thi...Accuracy validation is essential to clinical application of medical image registration techniques. Registration validation remains a challenging problem in practice mainly due to lack of 'ground truth'. In this paper, an overview of current validation methods for medical image registration is presented with detailed discussion of their benefits and drawbacks. Special focus is on non-rigid registration validation. Promising solution is also discussed.展开更多
One of the critical challenges that limit broad commercialization of proton exchange membrane fuel cells(PEMFC)is to reduce the usage of Pt while maintaining high power output and sufficient durability.Herein,a novel ...One of the critical challenges that limit broad commercialization of proton exchange membrane fuel cells(PEMFC)is to reduce the usage of Pt while maintaining high power output and sufficient durability.Herein,a novel bifunctional layer consisting of vertically aligned carbon nanotubes(VACNTs)and nanoparticles of Pt-Co catalysts(Pt-Co/VACNTs)is reported for highperformance PEMFCs.Readily prepared by a two-step process,the Pt-Co/VACNTs layer with a hydrophilic catalyst-loaded side and a hydrophobic gas diffusion side enables a PTFE-free electrode structure with fully exposed catalyst active sites and superior gas–water diffusion capability.When tested in a PEMFC,the bi-functional Pt-Co/VACNTs layer with ultralow Pt loading(~65μgcathodecm-2)demonstrates a power density of 19.5 kW gPt cathode-1 at 0.6 V,more than seven times that of a cell with commercial Pt/C catalyst(2.7 kW gPt cathode-1 at 0.6 V)at a loading of 400μgcathodecm-2 tested under similar conditions.This remarkable design of VACNTs-based catalyst with dual functionalities enables much lower Pt loading,faster mass transport,and higher electrochemical performance and stability.Further,the preparation procedure can be easily scaled up for low-cost fabrication and commercialization.展开更多
All-inorganic perovskite solar cells(PVSCs)have drawn widespread attention for its superior thermal stability.Carbon-based devices are promising to demonstrate excellent long-term operational stability due to the hydr...All-inorganic perovskite solar cells(PVSCs)have drawn widespread attention for its superior thermal stability.Carbon-based devices are promising to demonstrate excellent long-term operational stability due to the hydrophobicity of carbon materials and the abandon of organic holetransporting materials(HTMs).However,the difficulty to control the crystallinity process and the poor morphology leads to serious non-radiative recombination,resulting in low V_(OC)and power conversion efficiency(PCE).In this article,the crystal formation process of all-inorganic perovskites is controlled with a facile composition engineering strategy.By bromide incorporation,high-quality perovskite films with large grain and fewer grain boundaries are achieved.As-prepared perovskite films demonstrate longer carrier lifetime,contributing to lower energy loss and better device performance.Fabricated carbon-based HTM-free PVSCs with CsPbI_(2.33)Br_(0.67) perovskite realized champion PCE of 12.40%,superior to 8.80%of CsPbI_(3)-based devices,which is one of the highest efficiencies reported for the carbon-based all-inorganic PVSCs to date.The high V_(OC) of 1.01 V and FF of 70.98% indicate the significance of this composition engineering method.Moreover,fabricated carbon-based devices exhibit excellent stability,and unencapsulated device retains over 90%of its initial efficiency under continuous one sun illumination for 250 h in N_(2) atmosphere and keeps~84%of its original value after stored in ambient environment with RH 15–20% for 200 h.This work provides a facile way to fabricate high-performance and stable carbon-based all-inorganic PVSCs.展开更多
Recycled powder(RP)is produced as a by-product during the process of recycling construction and demolition(C&D)wastes,presenting a low additional value.Using RP-based solidifying material can not only improve its ...Recycled powder(RP)is produced as a by-product during the process of recycling construction and demolition(C&D)wastes,presenting a low additional value.Using RP-based solidifying material can not only improve its utilization efficiency,but also reduce the cost of commercial solidifying materials.To date,this is the best solidifying material utilized to dispose the original waterworks sludge(OWS)with high moisture contents(60%),and the product could be used to fabricate non-fired bricks.This has become a new environment-friendly technology of“using waste to treat waste”.In this paper,the influence of different particle sizes and dosages of RP on the prepared solidifying material was studied.Besides,unconfined compression strength(UCS),volume stability,chemical composition,and heat of hydration,pore structure of the solidifying material were characterized.Then,non-fired bricks were prepared by using the solidifying material,recycled aggregate,and original waterworks sludge.The UCS and softing coefficient(SC)of the non-fired bricks were evaluated.As a result,the 28-day UCS of the solidifying material with optimal(M30)was 35.40 MPa,which could reach 84.37%of Portland cement(PC).The addition of RP increased the volume stability of the solidifying material.The addition of a large amount of RP reduced the heat flux and cumulative heat release of the solidifying material,while its porosity increased.The UCS of non-fired brick(NF20)in 28 days was 15.19 MPa and the SC after 28 days was 78.35%.In conclusion,the preparation of solidifying material using RP could be a promising approach and has a great potential in disposal of original waterworks sludge.展开更多
Objective: To observe the clinical effect of tiotropium bromide in elderly patients with COPD at stable stage and its effects on pulmonary function,blood and serum inflammatory cytokine. Methods: 80 elderly patients w...Objective: To observe the clinical effect of tiotropium bromide in elderly patients with COPD at stable stage and its effects on pulmonary function,blood and serum inflammatory cytokine. Methods: 80 elderly patients with COPD s at stable stage were randomly divided into treatment group and control group with 40 patients in each group. The control group was treated with normal treatment. The treatment group was treated with tiotropium bromide on the basis of control group. 3 months after treatment, the pulmonary function、arterial blood gas and serum inflammatory cytokine were detected and compared in the two groups. Results:There was no significant difference in lung function index and TNF- alpha level between the two groups before treatment (P>0.05). The levels of FVC, FEV1% and PEF were increased and serum TNF-α was decreased significantly after treatment in two groups (P<0.05), and they were better than in treatment group than those in control group (all P<0.05);There was no significant difference in blood gas index between the two groups before treatment (P>0.05);In addition, there were no significant difference in the level of PCT, PaO2, PaCO2 and PaO2/FiO2 after treatment in control group, but the level of PCT and PaCO2 were higher and PaO2 and PaO2/FiO2 were lower obviously after treatment (P<0.01). The treatment group was superior to the control group (all P<0.05);Moreover, the curative effect of treatment group was better than that in control group (P<0.05). Conclusion: Tiotropium bromide can improve pulmonary function, pulmonary function、arterial blood gas and serum inflammatory cytokine in elderly stable COPD patients.展开更多
网络交换机对广播报文的处理即所有端口对该报文复制转发,若此时网络上有广播报文,则环路的形成会导致广播报文永远无法消除且被复制的越来越多,并在环形网络中形成广播风暴。因此,分析了冗余网络存在的问题,重点介绍了生成树协议(Spann...网络交换机对广播报文的处理即所有端口对该报文复制转发,若此时网络上有广播报文,则环路的形成会导致广播报文永远无法消除且被复制的越来越多,并在环形网络中形成广播风暴。因此,分析了冗余网络存在的问题,重点介绍了生成树协议(Spanning Tree Protocol,STP)算法的工作原理和核心思想,并提出STP算法在ARM9200处理器与BCM53115交换芯片上实现的具体方案。最后,通过组网测试验证了STP算法能够解决广播风暴问题的正确性。展开更多
Recycling the condensate water of the air conditioner could be explored as an alternative water source to con-tribute to building the green campus.This paper explored the condensate water production through actual mea...Recycling the condensate water of the air conditioner could be explored as an alternative water source to con-tribute to building the green campus.This paper explored the condensate water production through actual mea-surement based on a split air handling unit(SAHU)in a university building.Then,the statistical analysis was used to analyze the recycling feasibility and the impact factors of the condensate water production in 31 Chinese provincial capital cities to obtain the recycling potential map of the condensate water generated from a SAHU.Results showed that:(1)In the measurement,the amount of condensate water produced by a single split air conditioner was 1.6 kg from 12:40 to 13:40.Therefore,the daily output of condensate water of the air condi-tioner with the university operation schedule could reach 52.99 kg during the main air-conditioning season.(2)Among the 31 provincial capital cities in China,the largest condensate water outputs could be found in the Hot Summer and Warm Winter zone and the Hot Summer and Cold Winter zone,with an average monthly output of 1600 kg and 1100 kg,respectively.(3)Regression analysis showed that the dry-bulb temperature and dew point temperature of outdoor air had the highest positive and significant influence on condensate water production.The objective of this study is to provide theoretical guidance for the design and energy conservation evaluation of the feasibility of SAHU condensate water recycling in universities.展开更多
Background:Huangqi Guizhi Wuwu decoction(HQGZWW)exhibits good effects when administered to treat multiple sclerosis(MS)and its animal model,experimental autoimmune encephalomyelitis(EAE).Understanding the precise mech...Background:Huangqi Guizhi Wuwu decoction(HQGZWW)exhibits good effects when administered to treat multiple sclerosis(MS)and its animal model,experimental autoimmune encephalomyelitis(EAE).Understanding the precise mechanism of this decoction is thus important.Based on the findings of our previous study,the aim of the present study was to understand the role of antigen-specific CD8^(+)T-cells on the pathogene sis of MS/EAE when HQGZWW is administered as treatment.Methods:Myelin oligodendrocyte glycoprotein(MOG);-induced mice were administered distilled water,prednisone,and high dose or low dose HQGZWW.After purified CD4^(+)and CD8^(+)T-cells were stimulated with the MOG;peptide,proliferation and cytokine secretion assays were performed.To establish the adoptive transfer EAE model,naive mice were injected with MOG;-CD8^(+)or CD4^(+)T-cells.Results:Significant improvements in EAE score and pathology were observed in the high dose HQGZWW and prednisone groups.Compared to the low dose HQGZWW and distilled water groups,lower antigen-specific re sponses,lower levels of interferon-gamma,and higher levels of interleukin(IL)-4 and IL-10 from CD8^(+)and CD4^(+)T cells were observed in the high dose HQGZWW and prednisone groups.Finally,the EAE score was observed to be similar between the high dose HQGZWW group and prednisone group;however,this finding was not observed in the low dose HQGZWW group.Conclusion:Our findings suggest that high dose HQGZWW has similar effects on cell proliferation,cytokine secretion,and EAE score to prednisone,while low dose HQGZWW does not have such effect.The protective role of HQGZWW against EAE might thus depend on the Th2 cytokine secretion profile induced by either MOG;specific CD8^(+)or CD4^(+)T-cells.展开更多
Multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE),a pathologically similar disease used to model MS in rodents,are typical CD4^(^(+))T cell-dominated autoimmune diseases.CD4^(+)interleukin(IL)17...Multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE),a pathologically similar disease used to model MS in rodents,are typical CD4^(^(+))T cell-dominated autoimmune diseases.CD4^(+)interleukin(IL)17^(+)T cells(Th17 cells)have been well studied and have shown that they play a critical role in the pathogenesis of MS/EAE.However,studies have suggested that CD8^(+)IL17^(+)T cells(Tc17 cells)have a similar phenotype and cytokine and transcription factor profiles to those of Th17 cells and have been found to be crucial in the pathogenesis of autoimmune diseases,including MS/EAE,psoriasis,type I diabetes,rheumatoid arthritis,and systemic lupus erythematosus.However,the evidence for this is indirect and insufficient.Therefore,we searched for related publications and attempted to summarize the current knowledge on the role of Tc17 cells in the pathogenesis of MS/EAE,as well as in the pathogenesis of other autoimmune diseases,and to find out whether Tc17 cells or Th17 cells play a more critical role in autoimmune disease,especially in MS and EAE pathogenesis,or whether the interaction between these two cell types plays a critical role in the development of the disease.展开更多
基金Project supported by the Key R&D Program of Guangdong Province,China(Grant No.2018B030326001)the National Natural Science Foundation of China(Grant Nos.11474152,12074179,U21A20436,and 61521001)the Natural Science Foundation of Jiangsu Province,China(Grant No.BE2021015-1)。
文摘Quantum many-body systems in which time-reversal symmetry is broken give rise to a wealth of exotic phases,and thus constitute one of the frontiers of modern condensed matter physics.Quantum simulation allows us to better understand many-body systems with huge Hilbert space,where classical simulation is usually inefficient.With superconducting quantum circuit as a platform for quantum simulation,we realize synthetic Abelian gauge fields by using microwave drive and tunable coupling in loop configurations to break the time-reversal symmetry of the system.Based on high-precision manipulation and readout of circuit-QED architecture,we demonstrate the chiral ground spin current of a time-reversal symmetry broken system with nontrivial interactions.Our work is a significant attempt to simulate quantum many-body systems with time-reversal symmetry breaking in multi-qubit superconducting processors.
基金Supported by National Basic Research Program of China Grant(2011CB707701)National Natural Science Foundation of China(81127003)
文摘Accuracy validation is essential to clinical application of medical image registration techniques. Registration validation remains a challenging problem in practice mainly due to lack of 'ground truth'. In this paper, an overview of current validation methods for medical image registration is presented with detailed discussion of their benefits and drawbacks. Special focus is on non-rigid registration validation. Promising solution is also discussed.
基金supported by the National Natural Science Foundation of China under(No.21878158,2182880,51678291)Jiangsu Natural Science Foundation for Distinguished Young Scholars(No.BK20170043)+3 种基金the National Key R&D Program of China(2018YFB1502903)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)China Postdoctoral Science Foundation(2019M660112)the Jiangsu Postdoctoral Science Funding Project
文摘One of the critical challenges that limit broad commercialization of proton exchange membrane fuel cells(PEMFC)is to reduce the usage of Pt while maintaining high power output and sufficient durability.Herein,a novel bifunctional layer consisting of vertically aligned carbon nanotubes(VACNTs)and nanoparticles of Pt-Co catalysts(Pt-Co/VACNTs)is reported for highperformance PEMFCs.Readily prepared by a two-step process,the Pt-Co/VACNTs layer with a hydrophilic catalyst-loaded side and a hydrophobic gas diffusion side enables a PTFE-free electrode structure with fully exposed catalyst active sites and superior gas–water diffusion capability.When tested in a PEMFC,the bi-functional Pt-Co/VACNTs layer with ultralow Pt loading(~65μgcathodecm-2)demonstrates a power density of 19.5 kW gPt cathode-1 at 0.6 V,more than seven times that of a cell with commercial Pt/C catalyst(2.7 kW gPt cathode-1 at 0.6 V)at a loading of 400μgcathodecm-2 tested under similar conditions.This remarkable design of VACNTs-based catalyst with dual functionalities enables much lower Pt loading,faster mass transport,and higher electrochemical performance and stability.Further,the preparation procedure can be easily scaled up for low-cost fabrication and commercialization.
基金supported by the New Faculty Start-up Grant of the City University of Hong Kong(9610421)the ECS grant(City U 21301319)from the Research Grants Council of Hong Kong+4 种基金the Office of Naval Research(N00014-17-1-2201)Innovation and Technology Fund(ITS/497/18FP,GHP/021/18SZ)Natural Science Foundation of Guangdong Province(2019A1515010761)Guangdong Major Project of Basic and Applied Basic Research(No.2019B030302007)Guangdong-Hong Kong-Macao joint laboratory of optoelectronic and magnetic functional materials(No.2019B121205002)
文摘All-inorganic perovskite solar cells(PVSCs)have drawn widespread attention for its superior thermal stability.Carbon-based devices are promising to demonstrate excellent long-term operational stability due to the hydrophobicity of carbon materials and the abandon of organic holetransporting materials(HTMs).However,the difficulty to control the crystallinity process and the poor morphology leads to serious non-radiative recombination,resulting in low V_(OC)and power conversion efficiency(PCE).In this article,the crystal formation process of all-inorganic perovskites is controlled with a facile composition engineering strategy.By bromide incorporation,high-quality perovskite films with large grain and fewer grain boundaries are achieved.As-prepared perovskite films demonstrate longer carrier lifetime,contributing to lower energy loss and better device performance.Fabricated carbon-based HTM-free PVSCs with CsPbI_(2.33)Br_(0.67) perovskite realized champion PCE of 12.40%,superior to 8.80%of CsPbI_(3)-based devices,which is one of the highest efficiencies reported for the carbon-based all-inorganic PVSCs to date.The high V_(OC) of 1.01 V and FF of 70.98% indicate the significance of this composition engineering method.Moreover,fabricated carbon-based devices exhibit excellent stability,and unencapsulated device retains over 90%of its initial efficiency under continuous one sun illumination for 250 h in N_(2) atmosphere and keeps~84%of its original value after stored in ambient environment with RH 15–20% for 200 h.This work provides a facile way to fabricate high-performance and stable carbon-based all-inorganic PVSCs.
基金This work was supported by the Jiangsu Provincial Science and Technology Department’s Social Development-Major Science and Technology Demonstration Project(Grant No.BE2018697)the Demonstration Engineering Technology Research Center of Suqian Science and Technology Bureau(Grant No.M201912)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Recycled powder(RP)is produced as a by-product during the process of recycling construction and demolition(C&D)wastes,presenting a low additional value.Using RP-based solidifying material can not only improve its utilization efficiency,but also reduce the cost of commercial solidifying materials.To date,this is the best solidifying material utilized to dispose the original waterworks sludge(OWS)with high moisture contents(60%),and the product could be used to fabricate non-fired bricks.This has become a new environment-friendly technology of“using waste to treat waste”.In this paper,the influence of different particle sizes and dosages of RP on the prepared solidifying material was studied.Besides,unconfined compression strength(UCS),volume stability,chemical composition,and heat of hydration,pore structure of the solidifying material were characterized.Then,non-fired bricks were prepared by using the solidifying material,recycled aggregate,and original waterworks sludge.The UCS and softing coefficient(SC)of the non-fired bricks were evaluated.As a result,the 28-day UCS of the solidifying material with optimal(M30)was 35.40 MPa,which could reach 84.37%of Portland cement(PC).The addition of RP increased the volume stability of the solidifying material.The addition of a large amount of RP reduced the heat flux and cumulative heat release of the solidifying material,while its porosity increased.The UCS of non-fired brick(NF20)in 28 days was 15.19 MPa and the SC after 28 days was 78.35%.In conclusion,the preparation of solidifying material using RP could be a promising approach and has a great potential in disposal of original waterworks sludge.
文摘Objective: To observe the clinical effect of tiotropium bromide in elderly patients with COPD at stable stage and its effects on pulmonary function,blood and serum inflammatory cytokine. Methods: 80 elderly patients with COPD s at stable stage were randomly divided into treatment group and control group with 40 patients in each group. The control group was treated with normal treatment. The treatment group was treated with tiotropium bromide on the basis of control group. 3 months after treatment, the pulmonary function、arterial blood gas and serum inflammatory cytokine were detected and compared in the two groups. Results:There was no significant difference in lung function index and TNF- alpha level between the two groups before treatment (P>0.05). The levels of FVC, FEV1% and PEF were increased and serum TNF-α was decreased significantly after treatment in two groups (P<0.05), and they were better than in treatment group than those in control group (all P<0.05);There was no significant difference in blood gas index between the two groups before treatment (P>0.05);In addition, there were no significant difference in the level of PCT, PaO2, PaCO2 and PaO2/FiO2 after treatment in control group, but the level of PCT and PaCO2 were higher and PaO2 and PaO2/FiO2 were lower obviously after treatment (P<0.01). The treatment group was superior to the control group (all P<0.05);Moreover, the curative effect of treatment group was better than that in control group (P<0.05). Conclusion: Tiotropium bromide can improve pulmonary function, pulmonary function、arterial blood gas and serum inflammatory cytokine in elderly stable COPD patients.
文摘网络交换机对广播报文的处理即所有端口对该报文复制转发,若此时网络上有广播报文,则环路的形成会导致广播报文永远无法消除且被复制的越来越多,并在环形网络中形成广播风暴。因此,分析了冗余网络存在的问题,重点介绍了生成树协议(Spanning Tree Protocol,STP)算法的工作原理和核心思想,并提出STP算法在ARM9200处理器与BCM53115交换芯片上实现的具体方案。最后,通过组网测试验证了STP算法能够解决广播风暴问题的正确性。
基金funded by Sichuan Agriculture University,and is supported in part by the scholarship from China Scholarship Council(CSC)under the Grant CSC 202006915024.
文摘Recycling the condensate water of the air conditioner could be explored as an alternative water source to con-tribute to building the green campus.This paper explored the condensate water production through actual mea-surement based on a split air handling unit(SAHU)in a university building.Then,the statistical analysis was used to analyze the recycling feasibility and the impact factors of the condensate water production in 31 Chinese provincial capital cities to obtain the recycling potential map of the condensate water generated from a SAHU.Results showed that:(1)In the measurement,the amount of condensate water produced by a single split air conditioner was 1.6 kg from 12:40 to 13:40.Therefore,the daily output of condensate water of the air condi-tioner with the university operation schedule could reach 52.99 kg during the main air-conditioning season.(2)Among the 31 provincial capital cities in China,the largest condensate water outputs could be found in the Hot Summer and Warm Winter zone and the Hot Summer and Cold Winter zone,with an average monthly output of 1600 kg and 1100 kg,respectively.(3)Regression analysis showed that the dry-bulb temperature and dew point temperature of outdoor air had the highest positive and significant influence on condensate water production.The objective of this study is to provide theoretical guidance for the design and energy conservation evaluation of the feasibility of SAHU condensate water recycling in universities.
基金supported by Key Plans of Hunan Administration Traditional Chinese Medicine(No.201915 to YP)the grants from the Natural Science Foundation of Hunan Province.China(No.2018JJ6043 to YP)the Health and Family Plans commission of Hunan Province,China(No.B20180815to YP)。
文摘Background:Huangqi Guizhi Wuwu decoction(HQGZWW)exhibits good effects when administered to treat multiple sclerosis(MS)and its animal model,experimental autoimmune encephalomyelitis(EAE).Understanding the precise mechanism of this decoction is thus important.Based on the findings of our previous study,the aim of the present study was to understand the role of antigen-specific CD8^(+)T-cells on the pathogene sis of MS/EAE when HQGZWW is administered as treatment.Methods:Myelin oligodendrocyte glycoprotein(MOG);-induced mice were administered distilled water,prednisone,and high dose or low dose HQGZWW.After purified CD4^(+)and CD8^(+)T-cells were stimulated with the MOG;peptide,proliferation and cytokine secretion assays were performed.To establish the adoptive transfer EAE model,naive mice were injected with MOG;-CD8^(+)or CD4^(+)T-cells.Results:Significant improvements in EAE score and pathology were observed in the high dose HQGZWW and prednisone groups.Compared to the low dose HQGZWW and distilled water groups,lower antigen-specific re sponses,lower levels of interferon-gamma,and higher levels of interleukin(IL)-4 and IL-10 from CD8^(+)and CD4^(+)T cells were observed in the high dose HQGZWW and prednisone groups.Finally,the EAE score was observed to be similar between the high dose HQGZWW group and prednisone group;however,this finding was not observed in the low dose HQGZWW group.Conclusion:Our findings suggest that high dose HQGZWW has similar effects on cell proliferation,cytokine secretion,and EAE score to prednisone,while low dose HQGZWW does not have such effect.The protective role of HQGZWW against EAE might thus depend on the Th2 cytokine secretion profile induced by either MOG;specific CD8^(+)or CD4^(+)T-cells.
基金Fund for Creative Research Group of Affiliated First Hospital of Hunan Traditional Chinese Medical College, China(No. 2021B-003)Key Plans of Hunan Administration Traditional Chinese Medicine, China(No. 201915)+2 种基金Natural Science Foundation of Hunan Province, China(No. 2018JJ6043)Health and Family Planning Commission of Hunan Province, China(No. B20180815)Technology Plan Project of Zhuzhou City, Hunan Province, China(No. 2021-003)
文摘Multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE),a pathologically similar disease used to model MS in rodents,are typical CD4^(^(+))T cell-dominated autoimmune diseases.CD4^(+)interleukin(IL)17^(+)T cells(Th17 cells)have been well studied and have shown that they play a critical role in the pathogenesis of MS/EAE.However,studies have suggested that CD8^(+)IL17^(+)T cells(Tc17 cells)have a similar phenotype and cytokine and transcription factor profiles to those of Th17 cells and have been found to be crucial in the pathogenesis of autoimmune diseases,including MS/EAE,psoriasis,type I diabetes,rheumatoid arthritis,and systemic lupus erythematosus.However,the evidence for this is indirect and insufficient.Therefore,we searched for related publications and attempted to summarize the current knowledge on the role of Tc17 cells in the pathogenesis of MS/EAE,as well as in the pathogenesis of other autoimmune diseases,and to find out whether Tc17 cells or Th17 cells play a more critical role in autoimmune disease,especially in MS and EAE pathogenesis,or whether the interaction between these two cell types plays a critical role in the development of the disease.
