Summary of main observation and conclusion A highly regio-and chemo-selective dimeric Mn⑴-catalyzed hydroarylation and hydroalkenylation of unbiased internal alkenes with commercially abundant organoboron compounds i...Summary of main observation and conclusion A highly regio-and chemo-selective dimeric Mn⑴-catalyzed hydroarylation and hydroalkenylation of unbiased internal alkenes with commercially abundant organoboron compounds is reported.A wide range of densely functionalized aliphatic alkenyl amides can successfully undergo site-exclusive hydrocarbofunctionalization in air atmosphere without any exogenous directing auxiliary,affording an enhanced lead library of structurally diverse y-functionalized carboxylic acid derivatives in moderate to good yields.The precise chemoselectivity of the reaction among multiple alkene units even in the presence of reactive terminal alkenes highlights the unique catalytic features of manganese catalyst,and the excellent functional group compatibility of primary amides further complements other transition metals.展开更多
基金We thank the National Natural Science Foundation of China(Nos.21971108,21702098 and 21703118)the Fundamental Re-search Funds for the Central Universities(No.020514380214)+2 种基金the Natural Science Foundation of Jiangsu Province(No.BK20190006)"Innovation&Entrepreneurship Talents Plan"of Jiangsu Province,"Jiangsu Six Peak Talent Project",Shandong Provincial NaturalScience Foundation(No.ZR2017MB038)"1000-Youth Talent Plan"and start-up funds from Nanjing University for financial support.The DFT calculation is supported by High Performance ComputingCenter of Qufu Normal University.We thank Jie Dong and YuboPang to reproduce the products(3a and 3b).
文摘Summary of main observation and conclusion A highly regio-and chemo-selective dimeric Mn⑴-catalyzed hydroarylation and hydroalkenylation of unbiased internal alkenes with commercially abundant organoboron compounds is reported.A wide range of densely functionalized aliphatic alkenyl amides can successfully undergo site-exclusive hydrocarbofunctionalization in air atmosphere without any exogenous directing auxiliary,affording an enhanced lead library of structurally diverse y-functionalized carboxylic acid derivatives in moderate to good yields.The precise chemoselectivity of the reaction among multiple alkene units even in the presence of reactive terminal alkenes highlights the unique catalytic features of manganese catalyst,and the excellent functional group compatibility of primary amides further complements other transition metals.
