远红外Ge-Ga-Te-Ag硫系玻璃性能研究（英文）

采用传统的熔融-淬冷法制备了一系列的（Ge15Ga10Te75）100-x（Ag）x硫系玻璃样品.通过X射线衍射、差式扫描量热法、傅里叶红外光谱仪等测试了玻璃样品的热学及光学性能.结果表明该玻璃具有良好的非晶态特性和热稳定性,玻璃开始析晶温度和玻璃转变温度的差值都超过了100℃.随着Ag含量的增加,玻璃的吸收截止边产生了红移.通过提纯,Ge-Ga-Te-Ag玻璃在1.8-20μm有着较宽且平坦的红外光学窗口.Ge-Ga-Te-Ag玻璃组分的优良性质使其在红外领域具有广阔的应用前景.

Experimental and numerical investigation of mid-infrared laser in Pr^(3+)-doped chalcogenide fiber

We report on a chalcogenide glass fiber doped with Pr^(3+) that can be used for commercialized 1.5-μm and 2-μm laser excitations by emitting broadband 3 μm–5.5 μm fluorescence, which is extruded into a preform and then drawn into a step-index fiber. The spectroscopic properties of the fiber and glass are reported, and the mid-infrared fiber lasers are also numerically investigated. Cascade lasing is employed to increase the inversion population of the upper laser level. The particle swarm approach is applied to optimize the fiber laser parameters. The output power can reach 1.28 W at 4.89-μm wavelength, with a pump power of 5 W, excitation wavelength at 2.04 μm, Pr^(3+) ion concentration at 4.22 × 10^(25) ions/m^3,fiber length at 0.94 m, and fiber background loss at 3 dB/m.

LncRNA-ATB在胆汁淤积性肝病患者血清中的表达及意义

背景胆汁淤积性肝病(cholestatic liver disease,CSLD)是指能够引起胆汁淤积的多种肝病的集合和统称,其病因复杂,发病机制有待深入阐明,尚缺乏足够有效的治疗手段.近十余年来对CSLD的多个方面有了较多新认识,为其精准诊治提供了更多层面和更为有效的手段,同时许多问题仍然悬而未决,亟需继续深入研究.目的观察CSLD患者与正常人群中血清长链非编码RNA(long non coding RNA,LncRNA)-ATB水平的差异;探索CSLD患者血清LncRNA-ATB的变化与疾病病情的变化及预后的相关性.方法收集符合CSLD诊断标准的不同病因初诊肝病患者75例,同时收集健康对照者30例,采用qRT-PCR法检测LncRNA-ATB在上述研究对象血清标本中的表达;在分析比较正常对照与胆汁淤积、胆汁淤积不同程度各组间LncRNA-ATB水平差异性,采用线性相关分析LncRNA-ATB的变化与临床生化指标的相关性;采用受试者特征曲线分析LncRNA-ATB的变化对CSLD病情判断的临床意义.结果与健康对照组比较,LncRNA-ATB在CSLD患者中血清中明显增高,差异具有统计学意义(P<0.05).LncRNA-ATB的表达水平在不同病因导致的CSLD及不同病程的胆汁淤积患者之间的表达无明显差异(P>0.05).血清LncRNA-ATB随着胆汁淤积程度的加重而下降,差异具有统计学意义(P<0.001);LncRNAATB与TBA的量呈负相关关系(r=-0.627,P<0.001),LncRNA-ATB诊断CSLD的曲线下面积为0.856,敏感性为81.42%,特异性则为73.45%(95%CI:0.809-0.904,P<0.001).结论LncRNA-ATB在肝内CSLD患者血清中的含量明显升高,随着胆汁淤积程度的加重而下降,LncRNA-ATB的表达水平有望成为判断CSLD患者病情及预后的生物标志物.

Research progress of third-order optical nonlinearity of chalcogenide glasses

Chalcogenide glasses （ChGs） are a promising candidate for applications in nonlinear photonic devices. In this paper, we review the research progress of the third-order optical nonlinearity （TONL） of ChGs from the following three aspects： chemical composition, excitation condition, and post processing. The deficiencies in previous studies and further research of the TONL property of ChGs are also discussed.

Self-powered broadband kesterite photodetector with ultrahigh specific detectivity for weak light applications

Kesterite Cu_(2)ZnSn(S,Se)_(4)(CZTSSe)is a promising candidate for photodetector(PD)applications thanks to its excellent optoelectronic properties.In this work,a green solution-processed spin coating and selenization-processed thermodynamic or kinetic growth of high-quality narrow bandgap kesterite CZTSSe thin film is developed.A self-powered CZTSSe/CdS thin-film PD is then successfully fabricated.Under optimization of light absorber and heterojunction interface,especially tailoring the defect and carrier kinetics,it can achieve broadband response from300 to 1300 nm,accompaniedwith a high responsivity of 1.37A/W,specific detectivity(D*)up to 4.0×10^(14)Jones under 5 nW/cm^(2),a linear dynamic range(LDR)of 126 dB,and a maximum Ilight/Idark ratio of 1.3×10^(8)within the LDR,and ultrafast response speed(rise/decay time of 16 ns/85 ns),representing the leading-level performance to date,which is superior to those of commercial andwell-researched photodiodes.Additionally,an imaging system with a 905nm laser is built for weak light response evaluation,and can respond to 718 pW weak light and infrared imaging at a wavelength as low as 5 nW/cm2.It has also been employed for photoplethysmography detection of pulsating signals at both the finger and wrist,presenting obvious arterial blood volume changes,demonstrating great application potential in broadband and weak light photodetection scenarios.

Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats

Objective: To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets(SQTS) on sequelae post-stroke in rats.Methods: The rat cerebral ischemia sequelae post-stroke models were successfully induced by blocking the middle cerebral artery with electric coagulator after the seventh week and balance beam test ≤ 4. The rats were then received with SQTS(0.5, 1, and 2 g/kg) and Naodesheng(NDS, 1.24 g/kg), Vinpocetine(VP,1.55 mg/kg) for 30 d. The beam-walking test and shuttle test were performed before and after 10, 20, and 30 d of administration. In addition, histopathology changes and GAP-43, GFAP were measured by H&E staining and immunohistochemisty.Results: The model displayed signs of brain damage on motor function, learning and memory function and histopathology. After 30 d of treatment, SQTS at different doses(0.5, 1.0, and 2.0 g/kg) restored the beam-walking scores by 21.7%(P > 0.05), 30.4%(P > 0.05), and 39.1%(P < 0.05); Decreased electric shock by 35.0%(P > 0.05), 50.0%(P > 0.05), and 75.0%(P < 0.05), respectively. On the other hand, the histological changes were less severe and the GAP-43 expression increased in hippocampal CA1 and cortical region.Conclusion: SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity.

Predictive factors for the success of “one-off” ablation in single hepatocellular carcinoma patients who underwent percutaneous radiofrequency ablation

Aim:To investigate the technique’s effectiveness and evaluate the risk factors affecting the success of“one-off”percutaneous ultrasound-guided radiofrequency ablation(RFA)for single hepatocellular carcinoma(HCC).Methods:A total of 462 consecutive patients who received RFA from February 2010 to December 2013 at a single center(Eastern Hepatobiliary Surgery Hospital,Shanghai,China)were enrolled in the study.The patients were followed up for at least 6 months.Herein,this study adopted a new terminology named“one-off”ablation which is defined as achieving complete necrosis and no local residual or recurrent tumor within 6 months after single-session RFA.The incidence of“one-off”RFA was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive factors for the success of“one-off”ablation.Results:The technique’s effectiveness was 90.0%(416/462).After 6 months,281 patients achieved“one-off”ablation,while 181 patients failed.On univariate analysis,tumor size≤3 cm and tumor further from organs were found to be significantly correlated with“one-off”complete ablation(P=0.003,and P=0.010,respectively).On multivariate analysis using a logistic regression,tumor size≤3 cm[odds ratio(OR),0.534;95%confidence interval(CI):0.346-0.825,P=0.005]and tumor further from organs(OR,0.593;95%CI:0.387-0.909,P=0.017)remained predictive.Conclusion:Tumor size and tumor location are the predictive factors for the success of“one-off”ablation in patients with single HCC.

Arterial blood supply of hepatocellular carcinoma is associated with efficacy of sorafenib therapy

Aim:There are some previous reports concerning the relationship between prognosis of patients treated with sorafenib and parameters of computed tomography(CT)and magnetic resonance imaging(MRI).This study presents monocentric experience with sorafenib in the treatment of hepatocellular carcinoma(HCC)patients and will try to identify predictive factors for survival based on the correlation of results from imaging and survival.Methods:A total of 38 HCC patients treated from April 2009 to December 2010 with sorafenib were included in this study.HCCs were classified as good arterial supply and poor arterial supply according to the enhancement intensity on CT scan or MRI.Clinical data were collected and survival time was analyzed by Kaplan-Meier method.A Cox’s regression model was performed to reveal predictive factors for survival.Results:Among the 38 patients treated with sorafenib,mean age was 53.3±11.1 years and 35(92.1%)were males.Tumors in 17 patients were classified as good arterial supply,while the remaining 21 patients belonged to poor arterial supply.The median survival time(MST)was 10.7 months[95%confidence interval(CI),8.7-12.7]and the 1-year overall survival(OS)was 41.0%.The MST and 1-year OS in patients with a good arterial supply of tumors were 12 months(range:4-20 months)and 52.9%,compared with that of 7 months(range:1-16 months)and 23.8%in patients with a poor arterial supply of tumors(P=0.002).Patients who had tumors at Barcelona Clinic Liver Cancer(BCLC)stage B had longer MST and higher OS than those who had tumors at BCLC stage C,but there was no statistical difference between these two stages.On multivariate analysis,only arterial supply of the tumors remained statistically predictive for OS(hazard ratios 0.22,95%CI,0.07-0.67,P=0.008).Conclusion:Arterial blood supply is an independent predictor for survival in patients treated with sorafenib,and patients with a good arterial supply of tumors benefit more than those with a poor arterial supply of tumors.