Objective: To investigate the association between Mycoplasma pneumoniae (MP) infection and the occurrence of acute coronary syndromes (ACS), and its associated mechanism in ACS development. Methods: A total of 134 pat...Objective: To investigate the association between Mycoplasma pneumoniae (MP) infection and the occurrence of acute coronary syndromes (ACS), and its associated mechanism in ACS development. Methods: A total of 134 patients with confirmed ACS were selected as the ACS group, and another 102 healthy subjects were enrolled as the control group. Serum triglycerides (TG), cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) were detected using immuno-transmission turbidimetry in the ACS and control groups. An enzyme-linked immunosorbent assay was used to detect MP-specific IgG antibodies in the serum. Results:The MP infection rate in the ACS group was significantly higher than that in of the healthy control group. Although there were significant differences in the expression of TC, HDL, LDL, and ApoB between the ACS and control groups, there were no significant differences between the MP IgG-positive and negative groups for any the six serum lipid indexes in the ACS patients. The level of high-sensitivity C-reactive protein (hs-CRP) expression in ACS patients was significantly higher in the MP IgG-positive group compared with the negative group. Conclusions: MP infection is associated with ACS and may be a risk factor for ACS. MP infection may not affect blood lipid levels but rather induce the development of ACS by affecting the long-term inflammatory environment.展开更多
基金This research was funded by the National Natural Science Foundation of China(31672530)the Science and Technology Project of Henan Province(162300410091).
文摘Objective: To investigate the association between Mycoplasma pneumoniae (MP) infection and the occurrence of acute coronary syndromes (ACS), and its associated mechanism in ACS development. Methods: A total of 134 patients with confirmed ACS were selected as the ACS group, and another 102 healthy subjects were enrolled as the control group. Serum triglycerides (TG), cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) were detected using immuno-transmission turbidimetry in the ACS and control groups. An enzyme-linked immunosorbent assay was used to detect MP-specific IgG antibodies in the serum. Results:The MP infection rate in the ACS group was significantly higher than that in of the healthy control group. Although there were significant differences in the expression of TC, HDL, LDL, and ApoB between the ACS and control groups, there were no significant differences between the MP IgG-positive and negative groups for any the six serum lipid indexes in the ACS patients. The level of high-sensitivity C-reactive protein (hs-CRP) expression in ACS patients was significantly higher in the MP IgG-positive group compared with the negative group. Conclusions: MP infection is associated with ACS and may be a risk factor for ACS. MP infection may not affect blood lipid levels but rather induce the development of ACS by affecting the long-term inflammatory environment.
