A novel mixed collector (BHOA) was prepared by mixing benzohydroxamic acid (BHA) and sodium oleate (NaOL) and applied to the flotation separation of smithsonite from dolomite. Flotation results showed that NaOL alone ...A novel mixed collector (BHOA) was prepared by mixing benzohydroxamic acid (BHA) and sodium oleate (NaOL) and applied to the flotation separation of smithsonite from dolomite. Flotation results showed that NaOL alone had good collecting performance on smithsonite and common gangue mineral dolomite but had poor selectivity. By using a BHA/NaOL mixed system with a molar ratio of 2:1, the recoveries of smithsonite and dolomite reached approximately 90% and 5%, respectively. Surface tension analysis showed that the surface activity of BHOA was a little higher than that of a single NaOL because of synergistic effects. Zeta potential and X-ray photoelectron spectroscopy measurements indicated that surfactants BHA and NaOL co-absorbed on the smithsonite surface and only NaOL was present on the dolomite surface in the presence of BHOA.展开更多
The postnatal skeleton undergoes growth,modeling,and remodeling.The human skeleton is a composite of diverse tissue types,including bone,cartilage,fat,fibroblasts,nerves,blood vessels,and hematopoietic cells.Fracture ...The postnatal skeleton undergoes growth,modeling,and remodeling.The human skeleton is a composite of diverse tissue types,including bone,cartilage,fat,fibroblasts,nerves,blood vessels,and hematopoietic cells.Fracture nonunion and bone defects are among the most challenging clinical problems in orthopedic trauma.The incidence of nonunion or bone defects following fractures is increasing.Stem and progenitor cells mediate homeostasis and regeneration in postnatal tissue,including bone tissue.As multipotent stem cells,skeletal stem cells(SSCs)have a strong effect on the growth,differentiation,and repair of bone regeneration.In recent years,a number of important studies have characterized the hierarchy,differential potential,and bone formation of SSCs.Here,we describe studies on and applications of SSCs and/or mesenchymal stem cells for bone regeneration.展开更多
Polyacrylamide microspheres have been suc- cessfully used to reduce water production in reservoirs, but it is impossible to distinguish polyacrylamide microspheres from polyacrylamide that is used to enhance oil recov...Polyacrylamide microspheres have been suc- cessfully used to reduce water production in reservoirs, but it is impossible to distinguish polyacrylamide microspheres from polyacrylamide that is used to enhance oil recovery and is already present in production fluids. In order to detect polyacrylamide microspheres in the reservoir pro- duced fluid, fluorescent polyacrylamide microspheres P(AM-BA-AMCO), which fluoresce under ultraviolet irradiation, were synthesized via an inverse suspension polymerization. In order to keep the particle size distribu- tion in a narrow range, the synthesis conditions of the polymerization were studied, including the stirring speed and the concentrations of initiator, NaaCO3, and dispersant. The bonding characteristics of microspheres were deter- mined by Fourier transform infrared spectroscopy. The surface morphology of these microspheres was observed under ultraviolet irradiation with an inverse fluorescence microscope. A laboratory evaluation test showed that the fluorescent polymer microspheres had good water swelling capability, thus they had the ability to plug and migrate in a sand pack. The plugging rate was 99.8 % and the residual resistance coefficient was 800 after microsphere treatment in the sand pack. Furthermore, the fluorescent microspheres and their fragments were accurately detected under ultra- violet irradiation in the produced fluid, even though theyhad experienced extrusion and deformation in the sand pack.展开更多
Distal radius fracture is the most common fracture site of the human skeleton[1]and often occurs in young people resulting from high energy injury caused by severe trauma.However,complex distal radial intra-articular ...Distal radius fracture is the most common fracture site of the human skeleton[1]and often occurs in young people resulting from high energy injury caused by severe trauma.However,complex distal radial intra-articular fractures(AO type C3)are relatively rare and account for about 5%of all distal radius fractures.[2]Fracture comminution at the joint surface is the primary manifestation of these fractures,followed by avulsion of the bone fragments with displacement seen at both the metacarpal and ulnar bone.Treatment of these displaced and unstable fractures remains a challenge.The nature of the articular surface fracture indicates the use of either the open or close reduction technique.Treatment protocols focus on extra-articular reduction and restoration of radial length,maintaining the volar tilt.[3,4]It has been noted that incongruity of the intra-articular distal radius fracture is relevant to the development of arthritis.[5,6]展开更多
Background:Obstructive sleep apnea hypopnea syndrome (OSAHS) constitutes an independent factor for high warfarin dose for patients with pulmonary embolism (PE).The aim of this study was to investigate whether the...Background:Obstructive sleep apnea hypopnea syndrome (OSAHS) constitutes an independent factor for high warfarin dose for patients with pulmonary embolism (PE).The aim of this study was to investigate whether the 6-month anticoagulation treatment by warfarin is enough for patients with PE complicated by OSAHS.Methods:We investigated 97 PE patients,32 of them had OSAHS and 65 non-OSAHS.Warfarin was administered for 6-month if no abnormal circumstances occurred.All patients were followed up for 18 months.Adverse events (AE) included death,major bleeding,hospitalization due to heart failure or pulmonary hypertension,and recurrence or aggravation of PE (including deep vein thrombosis).Recurrence rate of PE after warfarin cessation was compared between the two groups.Results:OSAHS patients required a significantly higher dose of warfarin than their non-OSAHS counterparts (4.73 mg vs.3.61 mg,P 〈 0.001).During warfarin treatment,no major bleeding and aggravation of PE occurred among OSAHS patients,and the rates of various AE were not significantly different between the OSAHS and non-OSAHS groups.PE recurrence was higher in OSAHS than non-OSAHS groups after withdrawal of warfarin (21.43% vs.6.78%,P =0.047).Compared with non-OSAHS patients,OSAHS group had lower international normalized ratio (INR) value but higher plasminogen on baseline and INR resumed to a relatively low level after warfarin discontinuation.Conclusions:OSAHS patients may present with hypercoagulation and relatively high-risk of recurrence of PE after cessation of 6-month warfarin treatment.展开更多
Objective: To screen the preliminary phytochemical components, to investigate the acute oral toxicity, the analgesic and anti-inflammatory effects, and to analyze inflammatory factors on mice or rats of 70% ethanol e...Objective: To screen the preliminary phytochemical components, to investigate the acute oral toxicity, the analgesic and anti-inflammatory effects, and to analyze inflammatory factors on mice or rats of 70% ethanol extract of Zygopgyllurn macropodum aerial parts (ZME). Methods: Preliminary phytochemical screening was carried out by color reaction. Acute oral toxicity was investigated by body weight, relative organ weight and other toxic signs. Acetic acid induced writhing and hot plate test were used to determine analgesic effect. Acetic acid induced vascular permeability and carrageenan induced paw edema were used to confirm anti-inflammation. Protein in pleural effu- sion, prostaglandin E2 (PGE2) and tumor necrosis factor alpha (TNF-a) in serum of pleuritic rats induced by carrageenan were analyzed to explore the action mechanisms. The test groups received ZME with 100, 300, 600 mg/kg, the positive control with aspirin (ASP) 200 mg/kg for mice, and ZME with 70, 210, 420 mg/kg and ASP 150 mg/kg for rats orally. The control (C) or negative control (NC) groups received 2% Tween 80 of 10 mL/kg orally. Results: ZME contain flavonoids, saponins, phenols and tannins, steroids, terpenoids, fats and oils, glycosides, carbohydrates, and reducing sugar, but no alkaloids. The lethal dose 50% (LD50) of ZME was greater than 2000 mg/kg and no toxic or deleterious effects and death during 14 d. Oral administration 300 and 600 mgJkg of ZME produced analgesic and anti-inflammatory effects significantly (P 〈 0.05 or P 〈 0.001) vs NC. It can reduce the writhing number, prolong the heat resisting time, suppress the permeability of the capillary wall increasing, mitigate the paw edema, reduce the content of protein in pleural effusion, and reduce PGE2 and TNF-α in blood. Conclusions: ZME possessed analgesic and anti-inflammatory activities which related to inhibit the production of protein, PGE2 and TNF-α. The LD50 of ZME treated orally to mice was greater than 2000 mg/kg.展开更多
基金Project(51704329) supported by the National Natural Science Foundation of ChinaProject(2018YFC1901901) supported by the National Key Scientific Research Project of China
文摘A novel mixed collector (BHOA) was prepared by mixing benzohydroxamic acid (BHA) and sodium oleate (NaOL) and applied to the flotation separation of smithsonite from dolomite. Flotation results showed that NaOL alone had good collecting performance on smithsonite and common gangue mineral dolomite but had poor selectivity. By using a BHA/NaOL mixed system with a molar ratio of 2:1, the recoveries of smithsonite and dolomite reached approximately 90% and 5%, respectively. Surface tension analysis showed that the surface activity of BHOA was a little higher than that of a single NaOL because of synergistic effects. Zeta potential and X-ray photoelectron spectroscopy measurements indicated that surfactants BHA and NaOL co-absorbed on the smithsonite surface and only NaOL was present on the dolomite surface in the presence of BHOA.
文摘The postnatal skeleton undergoes growth,modeling,and remodeling.The human skeleton is a composite of diverse tissue types,including bone,cartilage,fat,fibroblasts,nerves,blood vessels,and hematopoietic cells.Fracture nonunion and bone defects are among the most challenging clinical problems in orthopedic trauma.The incidence of nonunion or bone defects following fractures is increasing.Stem and progenitor cells mediate homeostasis and regeneration in postnatal tissue,including bone tissue.As multipotent stem cells,skeletal stem cells(SSCs)have a strong effect on the growth,differentiation,and repair of bone regeneration.In recent years,a number of important studies have characterized the hierarchy,differential potential,and bone formation of SSCs.Here,we describe studies on and applications of SSCs and/or mesenchymal stem cells for bone regeneration.
基金supported by the National Natural Science Foundation of China (No.21273286)Doctoral Program Foundation of the Education Ministry (No.20130133110005)
文摘Polyacrylamide microspheres have been suc- cessfully used to reduce water production in reservoirs, but it is impossible to distinguish polyacrylamide microspheres from polyacrylamide that is used to enhance oil recovery and is already present in production fluids. In order to detect polyacrylamide microspheres in the reservoir pro- duced fluid, fluorescent polyacrylamide microspheres P(AM-BA-AMCO), which fluoresce under ultraviolet irradiation, were synthesized via an inverse suspension polymerization. In order to keep the particle size distribu- tion in a narrow range, the synthesis conditions of the polymerization were studied, including the stirring speed and the concentrations of initiator, NaaCO3, and dispersant. The bonding characteristics of microspheres were deter- mined by Fourier transform infrared spectroscopy. The surface morphology of these microspheres was observed under ultraviolet irradiation with an inverse fluorescence microscope. A laboratory evaluation test showed that the fluorescent polymer microspheres had good water swelling capability, thus they had the ability to plug and migrate in a sand pack. The plugging rate was 99.8 % and the residual resistance coefficient was 800 after microsphere treatment in the sand pack. Furthermore, the fluorescent microspheres and their fragments were accurately detected under ultra- violet irradiation in the produced fluid, even though theyhad experienced extrusion and deformation in the sand pack.
文摘Distal radius fracture is the most common fracture site of the human skeleton[1]and often occurs in young people resulting from high energy injury caused by severe trauma.However,complex distal radial intra-articular fractures(AO type C3)are relatively rare and account for about 5%of all distal radius fractures.[2]Fracture comminution at the joint surface is the primary manifestation of these fractures,followed by avulsion of the bone fragments with displacement seen at both the metacarpal and ulnar bone.Treatment of these displaced and unstable fractures remains a challenge.The nature of the articular surface fracture indicates the use of either the open or close reduction technique.Treatment protocols focus on extra-articular reduction and restoration of radial length,maintaining the volar tilt.[3,4]It has been noted that incongruity of the intra-articular distal radius fracture is relevant to the development of arthritis.[5,6]
文摘Background:Obstructive sleep apnea hypopnea syndrome (OSAHS) constitutes an independent factor for high warfarin dose for patients with pulmonary embolism (PE).The aim of this study was to investigate whether the 6-month anticoagulation treatment by warfarin is enough for patients with PE complicated by OSAHS.Methods:We investigated 97 PE patients,32 of them had OSAHS and 65 non-OSAHS.Warfarin was administered for 6-month if no abnormal circumstances occurred.All patients were followed up for 18 months.Adverse events (AE) included death,major bleeding,hospitalization due to heart failure or pulmonary hypertension,and recurrence or aggravation of PE (including deep vein thrombosis).Recurrence rate of PE after warfarin cessation was compared between the two groups.Results:OSAHS patients required a significantly higher dose of warfarin than their non-OSAHS counterparts (4.73 mg vs.3.61 mg,P 〈 0.001).During warfarin treatment,no major bleeding and aggravation of PE occurred among OSAHS patients,and the rates of various AE were not significantly different between the OSAHS and non-OSAHS groups.PE recurrence was higher in OSAHS than non-OSAHS groups after withdrawal of warfarin (21.43% vs.6.78%,P =0.047).Compared with non-OSAHS patients,OSAHS group had lower international normalized ratio (INR) value but higher plasminogen on baseline and INR resumed to a relatively low level after warfarin discontinuation.Conclusions:OSAHS patients may present with hypercoagulation and relatively high-risk of recurrence of PE after cessation of 6-month warfarin treatment.
基金supported by grants from the Department of Education of Xinjiang Uygur Autonomous Region (Grant No.XJEDU2013I32)Yili Normal University (2013YSZD03)
文摘Objective: To screen the preliminary phytochemical components, to investigate the acute oral toxicity, the analgesic and anti-inflammatory effects, and to analyze inflammatory factors on mice or rats of 70% ethanol extract of Zygopgyllurn macropodum aerial parts (ZME). Methods: Preliminary phytochemical screening was carried out by color reaction. Acute oral toxicity was investigated by body weight, relative organ weight and other toxic signs. Acetic acid induced writhing and hot plate test were used to determine analgesic effect. Acetic acid induced vascular permeability and carrageenan induced paw edema were used to confirm anti-inflammation. Protein in pleural effu- sion, prostaglandin E2 (PGE2) and tumor necrosis factor alpha (TNF-a) in serum of pleuritic rats induced by carrageenan were analyzed to explore the action mechanisms. The test groups received ZME with 100, 300, 600 mg/kg, the positive control with aspirin (ASP) 200 mg/kg for mice, and ZME with 70, 210, 420 mg/kg and ASP 150 mg/kg for rats orally. The control (C) or negative control (NC) groups received 2% Tween 80 of 10 mL/kg orally. Results: ZME contain flavonoids, saponins, phenols and tannins, steroids, terpenoids, fats and oils, glycosides, carbohydrates, and reducing sugar, but no alkaloids. The lethal dose 50% (LD50) of ZME was greater than 2000 mg/kg and no toxic or deleterious effects and death during 14 d. Oral administration 300 and 600 mgJkg of ZME produced analgesic and anti-inflammatory effects significantly (P 〈 0.05 or P 〈 0.001) vs NC. It can reduce the writhing number, prolong the heat resisting time, suppress the permeability of the capillary wall increasing, mitigate the paw edema, reduce the content of protein in pleural effusion, and reduce PGE2 and TNF-α in blood. Conclusions: ZME possessed analgesic and anti-inflammatory activities which related to inhibit the production of protein, PGE2 and TNF-α. The LD50 of ZME treated orally to mice was greater than 2000 mg/kg.