Two series monot ailed porphyrins, Cobalt-5- {4- [ω- （1-adamant aneamino） alkyloxy] phenyl }- 10,15,20-triphenyl porphyrinate （CoPCnA, n=4,5,6） and Nickel-5-{4-[ω-（1-adamantaneamino）alkyloxy]phenyl}-10,15.20- ...Two series monot ailed porphyrins, Cobalt-5- {4- [ω- （1-adamant aneamino） alkyloxy] phenyl }- 10,15,20-triphenyl porphyrinate （CoPCnA, n=4,5,6） and Nickel-5-{4-[ω-（1-adamantaneamino）alkyloxy]phenyl}-10,15.20- triphenyl porphyrinate （NiPCnA, n=4,5,6）, were synthesized, in which the porphyrin moiety was connected to l-adamantanamine via a flexible hydrocarbon chain. The fluorescence quenching between these donor substrates and mono-6-p-nitrobenzoyl-β-cyclodextrin （NBCD） was studied in detail. Distinct fluorescence quenching occured in these supramolecular systems. This quenching was attributed to the photoinduced electron transfer （PET） inside the supramolecular assembly between the porphyrin donors and cyclodextrin acceptors. Detailed Stern-Volmer constants were measured and they were partitioned into dynamic Stern- Volmer quenching constants and static binding constants. It was demonstrated that the PET interaction between the porphyrin subunits and NBCD is indeed effective.展开更多
Recently, medicinal peptide molecules are of great interest to many international pharmaceutical companies, mainly because of their relatively lower research costs, shorter research cycles, and the greater likelihood ...Recently, medicinal peptide molecules are of great interest to many international pharmaceutical companies, mainly because of their relatively lower research costs, shorter research cycles, and the greater likelihood of being drugs, when compared with traditional small molecules. Due to the great variety in molecule structures and the diverse biological functions, disulfide-rich peptide toxins have become a shining molecular library for the development of polypeptide drugs. In view of the increasing amount of related publications, here we summarize the discovery, structural elucidation and chemical synthesis of disulfide-rich peptide toxins and their analogs.展开更多
We develop a novel coumarin-all〈yne derivative （NC7-AL）, which can specifically react with Au^3＋ and give a colorimetric and fluorescent ＂turn-on＂ response toward Au3~, Notably, other alkynophilic metal species ...We develop a novel coumarin-all〈yne derivative （NC7-AL）, which can specifically react with Au^3＋ and give a colorimetric and fluorescent ＂turn-on＂ response toward Au3~, Notably, other alkynophilic metal species such as Au^＋, Ag^＋, Pd^2＋, Ni^2＋, Cu^2＋, and Hg^2＋ do not produce an interfering signal. A good linear relationship between emission intensity at 420 nm and Au^3＋ concentration from 0 to 2 equivalent is observed, and the detection limit （3σ/k） is estimated to be ca. 3.58 nmol/L. Harnessing the Au^3＋ .展开更多
基金V. ACKN0WLEDGMENT This work was supported Science Foundation of China by the National Natural （No.20472079）.
文摘Two series monot ailed porphyrins, Cobalt-5- {4- [ω- （1-adamant aneamino） alkyloxy] phenyl }- 10,15,20-triphenyl porphyrinate （CoPCnA, n=4,5,6） and Nickel-5-{4-[ω-（1-adamantaneamino）alkyloxy]phenyl}-10,15.20- triphenyl porphyrinate （NiPCnA, n=4,5,6）, were synthesized, in which the porphyrin moiety was connected to l-adamantanamine via a flexible hydrocarbon chain. The fluorescence quenching between these donor substrates and mono-6-p-nitrobenzoyl-β-cyclodextrin （NBCD） was studied in detail. Distinct fluorescence quenching occured in these supramolecular systems. This quenching was attributed to the photoinduced electron transfer （PET） inside the supramolecular assembly between the porphyrin donors and cyclodextrin acceptors. Detailed Stern-Volmer constants were measured and they were partitioned into dynamic Stern- Volmer quenching constants and static binding constants. It was demonstrated that the PET interaction between the porphyrin subunits and NBCD is indeed effective.
基金supported by National Natural Science Foundation of China (No. 21778001)
文摘Recently, medicinal peptide molecules are of great interest to many international pharmaceutical companies, mainly because of their relatively lower research costs, shorter research cycles, and the greater likelihood of being drugs, when compared with traditional small molecules. Due to the great variety in molecule structures and the diverse biological functions, disulfide-rich peptide toxins have become a shining molecular library for the development of polypeptide drugs. In view of the increasing amount of related publications, here we summarize the discovery, structural elucidation and chemical synthesis of disulfide-rich peptide toxins and their analogs.
基金supported by the National Natural Science Foundation of China (Nos. 21102001, 21271035 and 21372005)Anhui Provincial Natural Science Foundation (No. 1608085MB39)+1 种基金Natural Science Foundation of Education Department of Anhui Province (Nos. KJ2015A047, KJ2014A013)211 Project of Anhui University
文摘We develop a novel coumarin-all〈yne derivative （NC7-AL）, which can specifically react with Au^3＋ and give a colorimetric and fluorescent ＂turn-on＂ response toward Au3~, Notably, other alkynophilic metal species such as Au^＋, Ag^＋, Pd^2＋, Ni^2＋, Cu^2＋, and Hg^2＋ do not produce an interfering signal. A good linear relationship between emission intensity at 420 nm and Au^3＋ concentration from 0 to 2 equivalent is observed, and the detection limit （3σ/k） is estimated to be ca. 3.58 nmol/L. Harnessing the Au^3＋ .
