A sensitive analytical method to identify and determine aconitine and its metabolites in rabbit urine was developed by liquid chromatography-electrospray ionization mass spectrometry (LC/ESI-MSn).In this method,aconit...A sensitive analytical method to identify and determine aconitine and its metabolites in rabbit urine was developed by liquid chromatography-electrospray ionization mass spectrometry (LC/ESI-MSn).In this method,aconitine and its four metabolites in rabbit urine were isolated and deduced As 16-O-demethylaconine(M1), benzoylaconine(M2), 16-O-demethylbenzoylaconine (M3)and aconine(M4).M1 and M3 are new metabolites of aconitine and M2 and M4 are first identified in rabbit urine.展开更多
文摘A sensitive analytical method to identify and determine aconitine and its metabolites in rabbit urine was developed by liquid chromatography-electrospray ionization mass spectrometry (LC/ESI-MSn).In this method,aconitine and its four metabolites in rabbit urine were isolated and deduced As 16-O-demethylaconine(M1), benzoylaconine(M2), 16-O-demethylbenzoylaconine (M3)and aconine(M4).M1 and M3 are new metabolites of aconitine and M2 and M4 are first identified in rabbit urine.
