Coronavirus disease 2019 (COVID-19) is highly infectious and has spread worldwide. Medical staff may be exposed to the infection under circumstances of medical supply shortages and improper protection. How to better p...Coronavirus disease 2019 (COVID-19) is highly infectious and has spread worldwide. Medical staff may be exposed to the infection under circumstances of medical supply shortages and improper protection. How to better protect medical staff has become the focus of all walks of life. Therefore, during the COVID-19 outbreak, timely adjustments and optimization of nursing management strategies in isolation wards are important for improving care quality and reducing the infection of medical staff. Based on a literature review and clinical nursing management practices, this article summarizes the nursing management strategies in isolation wards during the COVID-19 outbreak, aiming to provide references for clinical nursing managers.展开更多
General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junct...General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junction-mediated signaling could influence general anesthetic-induced loss of consciousness. The general anesthetics sevoflurane and propofol were used. Intracerebroventricular administration of carbenoxolone, a gap junction blocker, significantly decreased the time to loss of the righting reflex （P 0.05）, but prolonged the time to recovery of the reflex （P 0.05）. Moreover, intracerebroventricular administration of carbenoxolone increased the sensitivity to sevoflurane, with a leftward shift of the loss of righting reflex dose-response curve, and decreased the 50% effective concentration of sevoflurane. These results suggest that the gap junction blocker carbenoxolone enhances propofol and sevoflurane-mediated general anesthesia.展开更多
Nitrogen-vacancy color centers can perform highly sensitive and spatially resolved quantum measurements of physical quantities such as magnetic field,temperature,and pressure.Meanwhile,sensing so many variables at the...Nitrogen-vacancy color centers can perform highly sensitive and spatially resolved quantum measurements of physical quantities such as magnetic field,temperature,and pressure.Meanwhile,sensing so many variables at the same time often introduces additional noise,causing a reduced accuracy.Here,a dual-microwave time-division multiplexing protocol is used in conjunction with a lock-in amplifier in order to decouple temperature from the magnetic field and vice versa.In this protocol,dual-frequency driving and frequency modulation are used to measure the magnetic and temperature field simultaneously in real time.The sensitivity of our system is about 3.4 nT=√Hz p and 1.3 mK=√Hz p,respectively.Our detection protocol not only enables multifunctional quantum sensing,but also extends more practical applications.展开更多
Modulation of a vector light field has played an important role in the research of nanophotonics.However,it is still a great challenge to accurately measure the three-dimensional vector distribution at nanoscale.Here,...Modulation of a vector light field has played an important role in the research of nanophotonics.However,it is still a great challenge to accurately measure the three-dimensional vector distribution at nanoscale.Here,based on the interaction between the light field and atomic-sized nitrogen-vacancy(NV)color center in diamonds,we demonstrate an efficient method for vectorial mapping of the light-field distribution at nanoscale.Single NV centers with different but well-defined symmetry axes are selected and then interact with the same tightly focused light field.The excitation of a single NV center is related to the angle between the NV center axis and the polarization of the light field.Then the fluorescence patterns of different NV centers provide the information on the vectorial light field distribution.Subsequently analyzing the fluorescence patterns with the help of a deep neural network,the intensity and phase of the light-field vectorial components are fully reconstructed with nanometer resolution.The experimental results are in agreement with theoretical calculations.It demonstrates that our method can help to study light–matter interaction at nanoscale and extend the application of vector light fields in research on nanophotonics.展开更多
As a potential candidate for quantum computation and metrology,the nitrogen vacancy(NV)center in diamond presents both challenges and opportunities resulting from charge-state conversion.By utilizing different lasers ...As a potential candidate for quantum computation and metrology,the nitrogen vacancy(NV)center in diamond presents both challenges and opportunities resulting from charge-state conversion.By utilizing different lasers for the photon-induced charge-state conversion,we achieved subdiffraction charge-state manipulation.The charge-state depletion(CSD)microscopy resolution was improved to 4.1 nm by optimizing the laser pulse sequences.Subsequently,the electron spin-state dynamics of adjacent NV centers were selectively detected via the CSD.The experimental results demonstrated that the CSD can improve the spatial resolution of the measurement of NV centers for nanoscale sensing and quantum information.展开更多
The nitrogen vacancy(NV)center in diamond has been well applied in quantum sensing of electromagnetic field and temperature,where the sensitivity can be enhanced by the number of NV centers.Here,we used electron beam ...The nitrogen vacancy(NV)center in diamond has been well applied in quantum sensing of electromagnetic field and temperature,where the sensitivity can be enhanced by the number of NV centers.Here,we used electron beam irradiation to increase the generation rate of NV centers by nearly 22 times.We systematically studied the optical and electronic properties of the NV center as a function of an electron irradiation dose,where the detection sensitivity of magnetic fields was improved.With such samples with dense NV centers,a sub-pico-Tesla sensitivity in magnetic fields detection can be achieved with optimal controls and detections.展开更多
文摘Coronavirus disease 2019 (COVID-19) is highly infectious and has spread worldwide. Medical staff may be exposed to the infection under circumstances of medical supply shortages and improper protection. How to better protect medical staff has become the focus of all walks of life. Therefore, during the COVID-19 outbreak, timely adjustments and optimization of nursing management strategies in isolation wards are important for improving care quality and reducing the infection of medical staff. Based on a literature review and clinical nursing management practices, this article summarizes the nursing management strategies in isolation wards during the COVID-19 outbreak, aiming to provide references for clinical nursing managers.
基金supported by the Natural Science Foundation of Hubei Province, No. 2010CHB01001
文摘General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junction-mediated signaling could influence general anesthetic-induced loss of consciousness. The general anesthetics sevoflurane and propofol were used. Intracerebroventricular administration of carbenoxolone, a gap junction blocker, significantly decreased the time to loss of the righting reflex （P 0.05）, but prolonged the time to recovery of the reflex （P 0.05）. Moreover, intracerebroventricular administration of carbenoxolone increased the sensitivity to sevoflurane, with a leftward shift of the loss of righting reflex dose-response curve, and decreased the 50% effective concentration of sevoflurane. These results suggest that the gap junction blocker carbenoxolone enhances propofol and sevoflurane-mediated general anesthesia.
基金supported by the National Natural Science Foundation of China(Nos.12005218 and 52130510).
文摘Nitrogen-vacancy color centers can perform highly sensitive and spatially resolved quantum measurements of physical quantities such as magnetic field,temperature,and pressure.Meanwhile,sensing so many variables at the same time often introduces additional noise,causing a reduced accuracy.Here,a dual-microwave time-division multiplexing protocol is used in conjunction with a lock-in amplifier in order to decouple temperature from the magnetic field and vice versa.In this protocol,dual-frequency driving and frequency modulation are used to measure the magnetic and temperature field simultaneously in real time.The sensitivity of our system is about 3.4 nT=√Hz p and 1.3 mK=√Hz p,respectively.Our detection protocol not only enables multifunctional quantum sensing,but also extends more practical applications.
基金was supported by the Innovation Program for Quantum Science and Technology(No.2021ZD0303200)the National Natural Science Foundation of China(No.62225506)+1 种基金the CAS Project for Young Scientists in Basic Research(No.YSBR-049)the Key Research and Development Program of Anhui Province(No.2022b13020006)。
文摘Modulation of a vector light field has played an important role in the research of nanophotonics.However,it is still a great challenge to accurately measure the three-dimensional vector distribution at nanoscale.Here,based on the interaction between the light field and atomic-sized nitrogen-vacancy(NV)color center in diamonds,we demonstrate an efficient method for vectorial mapping of the light-field distribution at nanoscale.Single NV centers with different but well-defined symmetry axes are selected and then interact with the same tightly focused light field.The excitation of a single NV center is related to the angle between the NV center axis and the polarization of the light field.Then the fluorescence patterns of different NV centers provide the information on the vectorial light field distribution.Subsequently analyzing the fluorescence patterns with the help of a deep neural network,the intensity and phase of the light-field vectorial components are fully reconstructed with nanometer resolution.The experimental results are in agreement with theoretical calculations.It demonstrates that our method can help to study light–matter interaction at nanoscale and extend the application of vector light fields in research on nanophotonics.
基金This study was financially supported by the National Basic Research Program of China(Grant No.2011CB921200)the Knowledge Innovation Project of Chinese Academy of Sciences(Grant No.60921091)+3 种基金the National Natural Science Foundation of China(Grant No.11374290)the Program for New Century Excellent Talents in Universitythe Fundamental Research Funds for the Central Universitiesthe Foundation for the Author of National Excellent Doctoral Dissertation of China.
文摘As a potential candidate for quantum computation and metrology,the nitrogen vacancy(NV)center in diamond presents both challenges and opportunities resulting from charge-state conversion.By utilizing different lasers for the photon-induced charge-state conversion,we achieved subdiffraction charge-state manipulation.The charge-state depletion(CSD)microscopy resolution was improved to 4.1 nm by optimizing the laser pulse sequences.Subsequently,the electron spin-state dynamics of adjacent NV centers were selectively detected via the CSD.The experimental results demonstrated that the CSD can improve the spatial resolution of the measurement of NV centers for nanoscale sensing and quantum information.
基金supported by the National Key Research and Development Program of China(No.2017YFA0304504)the National Natural Science Foundation of China(Nos.91536219 and 91850102)+2 种基金the Anhui Initiative in Quantum Information Technologies(No.AHY130000)the Science Challenge Project(No.TZ2018003)the Fundamental Research Funds for the Central Universities(No.WK2030000020)。
文摘The nitrogen vacancy(NV)center in diamond has been well applied in quantum sensing of electromagnetic field and temperature,where the sensitivity can be enhanced by the number of NV centers.Here,we used electron beam irradiation to increase the generation rate of NV centers by nearly 22 times.We systematically studied the optical and electronic properties of the NV center as a function of an electron irradiation dose,where the detection sensitivity of magnetic fields was improved.With such samples with dense NV centers,a sub-pico-Tesla sensitivity in magnetic fields detection can be achieved with optimal controls and detections.
