Glioma is the most common central nervous system primary tumor,accounting for about 40%of intracranial tumors.In recent years,studies have shown that the human brain is not immune-free zone.The low immunogenicity of t...Glioma is the most common central nervous system primary tumor,accounting for about 40%of intracranial tumors.In recent years,studies have shown that the human brain is not immune-free zone.The low immunogenicity of the tumor itself,tumor-generated immunosuppressive factors,and the low immunity of tumor patients all contribute to the“immune escape”phenomenon of glioma cells.Dendritic cells(DCs),as the strongest antigen-presenting cells in the body,play an important role in tumor immunotherapy with T-cell recognizing tumor antigens as the core.Therefore,it is necessary to adopt a strategy of culturing and sensitizing DC cells in vitro to increase their number and improve their function before returning to the body for treatment of patients with glioma.展开更多
文摘Glioma is the most common central nervous system primary tumor,accounting for about 40%of intracranial tumors.In recent years,studies have shown that the human brain is not immune-free zone.The low immunogenicity of the tumor itself,tumor-generated immunosuppressive factors,and the low immunity of tumor patients all contribute to the“immune escape”phenomenon of glioma cells.Dendritic cells(DCs),as the strongest antigen-presenting cells in the body,play an important role in tumor immunotherapy with T-cell recognizing tumor antigens as the core.Therefore,it is necessary to adopt a strategy of culturing and sensitizing DC cells in vitro to increase their number and improve their function before returning to the body for treatment of patients with glioma.
