Relying on the great success in portable and smart devices,lithium ion batteries(LIBs)have been considered as one of the leading technologies in electric vehicles(EVs)and stationary energy storage systems(ESSs).With t...Relying on the great success in portable and smart devices,lithium ion batteries(LIBs)have been considered as one of the leading technologies in electric vehicles(EVs)and stationary energy storage systems(ESSs).With the rapid development of EVs and ESSs,the technology upgrading of LIBs is highly demanded.As expected,it requires LIBs with improved power and energy densities[1].展开更多
Lithium ion batteries(LIBs)have been widely used in portable and smart devices because of their high energy densities,long cycle life and environmental friendliness.In order to meet the evergrowing demand for human-be...Lithium ion batteries(LIBs)have been widely used in portable and smart devices because of their high energy densities,long cycle life and environmental friendliness.In order to meet the evergrowing demand for human-beings utilizing electronic devices,electric vehicles and energy storage grids.展开更多
Multiple myeloma (MM) is a plasma cell neoplasm characterized for its fast evolution and for being practically incurable, presenting a strong need for the development of therapies to target it. Among those under study...Multiple myeloma (MM) is a plasma cell neoplasm characterized for its fast evolution and for being practically incurable, presenting a strong need for the development of therapies to target it. Among those under study are lenalidomide and arsenic trioxide (ATO) which show individual clinical promise, although never tested together. However, the combination of ATO with thalidomide, another immunomodulatory drug and lenalidomide’s structural albeit less potent analog, have been tried clinically with some success. Therefore, we investigated the effect the combination of lenalidomide and ATO have on the MM-derived U266 and RPMI 8226 cell lines. We observed that both compounds have separate, non-interfering, anti-myeloma mechanisms with ATO demonstrating strong cytotoxic effects while lenalidomide’s role remains cytostatic and immunomodulatory. However, ATO decreases cdc25c, which helps sensitize cells to lenalidomide effects enhancing the efficacy of their interaction. Mechanistically the combination of these two agents decreased the expression of MDM2, without affecting p53 activation or its expression. Therefore, this short study provides the foundation to continue mechanistic studies of the combination of lenalidomide and ATO as a foundation for future clinical application.展开更多
1. Introduction As the state-of-the-art power resources, lithium ion batteries(LIBs) have dominated the market of smart and portable electronic devices over the past several decades. At present, LIBs have been conside...1. Introduction As the state-of-the-art power resources, lithium ion batteries(LIBs) have dominated the market of smart and portable electronic devices over the past several decades. At present, LIBs have been considered as one of the leading technologies for electric vehicles(EVs) and stationary energy storage systems(ESSs) [1,2]. In order to meet the high demands arising from large-scale applications of EVs and ESSs, the development of LIBs with high energy densities, long cycle life and safe operating environment becomes critically important.展开更多
基金financial support from the Pearl River Talent Recruitment Program(2019QN01L096)China the Guangdong Innovative and Entrepreneurial Research Team Program(2019ZT08L075)+1 种基金China the Guangdong Science and Technology Program(2020B121201003)China and the“Young Talent Fellowship”Program through South China University of Technology。
文摘Relying on the great success in portable and smart devices,lithium ion batteries(LIBs)have been considered as one of the leading technologies in electric vehicles(EVs)and stationary energy storage systems(ESSs).With the rapid development of EVs and ESSs,the technology upgrading of LIBs is highly demanded.As expected,it requires LIBs with improved power and energy densities[1].
基金financial support from the“Young Talent Fellowship”program through South China University of Technologythe Fundamental Research Funds for the Central Universities(2018JQ06)。
文摘Lithium ion batteries(LIBs)have been widely used in portable and smart devices because of their high energy densities,long cycle life and environmental friendliness.In order to meet the evergrowing demand for human-beings utilizing electronic devices,electric vehicles and energy storage grids.
文摘Multiple myeloma (MM) is a plasma cell neoplasm characterized for its fast evolution and for being practically incurable, presenting a strong need for the development of therapies to target it. Among those under study are lenalidomide and arsenic trioxide (ATO) which show individual clinical promise, although never tested together. However, the combination of ATO with thalidomide, another immunomodulatory drug and lenalidomide’s structural albeit less potent analog, have been tried clinically with some success. Therefore, we investigated the effect the combination of lenalidomide and ATO have on the MM-derived U266 and RPMI 8226 cell lines. We observed that both compounds have separate, non-interfering, anti-myeloma mechanisms with ATO demonstrating strong cytotoxic effects while lenalidomide’s role remains cytostatic and immunomodulatory. However, ATO decreases cdc25c, which helps sensitize cells to lenalidomide effects enhancing the efficacy of their interaction. Mechanistically the combination of these two agents decreased the expression of MDM2, without affecting p53 activation or its expression. Therefore, this short study provides the foundation to continue mechanistic studies of the combination of lenalidomide and ATO as a foundation for future clinical application.
基金supported by the Pearl River Talent Recruitment Program (2019QN01L096)the Guangdong Innovative and Entrepreneurial Research Team Program (2019ZT08L075)+1 种基金the Guangdong Science and Technology Program (2020B121201003)the “Young Talent Fellowship” Program through South China University of Technology。
文摘1. Introduction As the state-of-the-art power resources, lithium ion batteries(LIBs) have dominated the market of smart and portable electronic devices over the past several decades. At present, LIBs have been considered as one of the leading technologies for electric vehicles(EVs) and stationary energy storage systems(ESSs) [1,2]. In order to meet the high demands arising from large-scale applications of EVs and ESSs, the development of LIBs with high energy densities, long cycle life and safe operating environment becomes critically important.