Global climate change makes forestry carbon sequestration a hot issue. In order to improve the comprehensive benefits of forest management, this paper studies the carbon accounting problem, and uses the forest stock c...Global climate change makes forestry carbon sequestration a hot issue. In order to improve the comprehensive benefits of forest management, this paper studies the carbon accounting problem, and uses the forest stock conversion factor method to create a carbon sequestration accounting model based on the reserve transformation method. Then, the HWP carbon sequestration accounting algorithm is obtained after the improvement of the reserve change method and the atmospheric flow method with the HWP half-life as a bridge. Based on the ecological and economic benefits, a multi-objective and multi-attribute decision-making model for forest management plan is constructed, and the optimal strategy of stand structure based on selective cutting is proposed. Finally, the entropy weight TOPSIS method is used to quantitatively analyze the comprehensive benefit value and provide suggestions for forestry departments. To verify the model, we chose the Greater Khingan Mountains forest region as the research site. Through successive iterations of CSAM, we calculate that the forest will absorb 534 million tons of live forest and forest products in 100 years. From the stand structure of the forest area, when the selected cutting intensity is 20% and the selected cutting cycle is 10.7 years, the comprehensive benefit value of the Greater Khingan Mountains is the highest.展开更多
Heavy rainfall events often occur in Beijing during summer but rarely in autumn. However,during 3-5 September2015, an exceptionally heavy rainfall event occurred in Beijing. Based on the reanalysis data and the Weathe...Heavy rainfall events often occur in Beijing during summer but rarely in autumn. However,during 3-5 September2015, an exceptionally heavy rainfall event occurred in Beijing. Based on the reanalysis data and the Weather Research and Forecasting(WRF) model simulations, the main contributing factors and the predictability of this heavy rainfall event were examined through comprehensive analyses of vorticity advection and water vapor transport/budget. The results indicate that a "high-in-the-east-low-in-the-west" pattern of 500-hPa geopotential height over the Beijing area played an important role. The 850-hPa low-level jet(LLJ) provided a mechanism for rising motion and transported abundant water vapor into the Beijing area. Two-way nested hindcast experiments using WRF well reproduced the atmospheric circulation and LLJ. Quantitative analysis indicates that the WRF model with the rapid update cycle(RUC) land surface scheme and the single-moment 6-class(WSM6) microphysics scheme exhibited the best skill, and the model performance improved with a higher resolution. Further analysis indicates that the bias in the precipitation forecast was caused by the bias in water vapor transport.展开更多
In this study,a micro-patterned hydroxyapatite/silk fibroin(HA-SF)coating was firstly fabricated on the surface of Mg-Zn-Y-Nd-Zr alloy by template-assisted electrospraying technique coupling with spin coating techniqu...In this study,a micro-patterned hydroxyapatite/silk fibroin(HA-SF)coating was firstly fabricated on the surface of Mg-Zn-Y-Nd-Zr alloy by template-assisted electrospraying technique coupling with spin coating technique.Two types of micro-patterns were achieved with high contour accuracy,namely HA SF(line-pattern)and HA-SF(dot-pattern).The microstructure,composition,surface wettability and corrosion behaviors of the coatings were investigated by SEM,EDS,FTIR,XRD,water contact angle and potentiodynamic polarization test.The results revealed the hydrophilic nature of coatings and two orders of magnitude reduction of corrosion density(icorr)as compared with that of the substrate.All the micro-patterned surfaces promoted the attachment of MC3T3-E1 cells with visible filopodia after 1 d incubation.In addition,coatings with line pattern exhibited the superior guidance to cell migration as compared to dot pattern,and the preference of cell attachment in the convex zone was observed.In summary,the obtained micro-patterned HA-SF coatings possessed the remarkably improvement of anticorrosion ability and good efficacy in guidance of cell attachment and alignment,which can serve as a promising strategy for cellular response modulation at the interface of magnesium-based implants and bone.展开更多
Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue in response to infection. Recently, a neutrophil cell surface receptor, CD177, wa...Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue in response to infection. Recently, a neutrophil cell surface receptor, CD177, was shown to help mediate neutrophil migration across the endothelium through interactions with PECAMI. We examined a publicly available gene array dataset of CD177 expression from human neutrophils following pulmonary endotoxin instillation. Among all 22,214 genes examined, CD177 mRNA was the most upregu- lated following endotoxin exposure. The high level of CD177 expression is also maintained in airspace neu- trophils, suggesting a potential involvement of CD177 in neutrophil infiltration under infectious diseases. To determine the role of CD177 in neutrophils in vivo, we constructed a CD177-genetic knockout mouse model. The mice with homozygous deletion of CD177 have no discernible phenotype and no significant change in immune cells, other than decreased neutrophil counts in peripheral blood. We examined the role of CD177 in neutrophil accumulation using a skin infection model with Staphylococcus aureus. CD177 deletion reducedneutrophil counts in inflammatory skin caused by S. aureus. Mechanistically we found that CD177 deletion in mouse neutrophils has no significant impact in CXCLI/ KC- or fMLP-induced migration, but led to significant cell death. Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.展开更多
文摘Global climate change makes forestry carbon sequestration a hot issue. In order to improve the comprehensive benefits of forest management, this paper studies the carbon accounting problem, and uses the forest stock conversion factor method to create a carbon sequestration accounting model based on the reserve transformation method. Then, the HWP carbon sequestration accounting algorithm is obtained after the improvement of the reserve change method and the atmospheric flow method with the HWP half-life as a bridge. Based on the ecological and economic benefits, a multi-objective and multi-attribute decision-making model for forest management plan is constructed, and the optimal strategy of stand structure based on selective cutting is proposed. Finally, the entropy weight TOPSIS method is used to quantitatively analyze the comprehensive benefit value and provide suggestions for forestry departments. To verify the model, we chose the Greater Khingan Mountains forest region as the research site. Through successive iterations of CSAM, we calculate that the forest will absorb 534 million tons of live forest and forest products in 100 years. From the stand structure of the forest area, when the selected cutting intensity is 20% and the selected cutting cycle is 10.7 years, the comprehensive benefit value of the Greater Khingan Mountains is the highest.
基金Supported by the National Nature Science Foundation of China(41325018 and 41421004)State Administration of Foreign Experts Affairs of P.R.China
文摘Heavy rainfall events often occur in Beijing during summer but rarely in autumn. However,during 3-5 September2015, an exceptionally heavy rainfall event occurred in Beijing. Based on the reanalysis data and the Weather Research and Forecasting(WRF) model simulations, the main contributing factors and the predictability of this heavy rainfall event were examined through comprehensive analyses of vorticity advection and water vapor transport/budget. The results indicate that a "high-in-the-east-low-in-the-west" pattern of 500-hPa geopotential height over the Beijing area played an important role. The 850-hPa low-level jet(LLJ) provided a mechanism for rising motion and transported abundant water vapor into the Beijing area. Two-way nested hindcast experiments using WRF well reproduced the atmospheric circulation and LLJ. Quantitative analysis indicates that the WRF model with the rapid update cycle(RUC) land surface scheme and the single-moment 6-class(WSM6) microphysics scheme exhibited the best skill, and the model performance improved with a higher resolution. Further analysis indicates that the bias in the precipitation forecast was caused by the bias in water vapor transport.
基金supported by the National Natural Science Foundation of China(Grant Nos.51601169,51671175 and 51701184)the National Key Research and Development Program of China(2018YFC1106703)the Key Projects of the Joint Fund of the National Natural Science Foundation of China(U1804251)。
文摘In this study,a micro-patterned hydroxyapatite/silk fibroin(HA-SF)coating was firstly fabricated on the surface of Mg-Zn-Y-Nd-Zr alloy by template-assisted electrospraying technique coupling with spin coating technique.Two types of micro-patterns were achieved with high contour accuracy,namely HA SF(line-pattern)and HA-SF(dot-pattern).The microstructure,composition,surface wettability and corrosion behaviors of the coatings were investigated by SEM,EDS,FTIR,XRD,water contact angle and potentiodynamic polarization test.The results revealed the hydrophilic nature of coatings and two orders of magnitude reduction of corrosion density(icorr)as compared with that of the substrate.All the micro-patterned surfaces promoted the attachment of MC3T3-E1 cells with visible filopodia after 1 d incubation.In addition,coatings with line pattern exhibited the superior guidance to cell migration as compared to dot pattern,and the preference of cell attachment in the convex zone was observed.In summary,the obtained micro-patterned HA-SF coatings possessed the remarkably improvement of anticorrosion ability and good efficacy in guidance of cell attachment and alignment,which can serve as a promising strategy for cellular response modulation at the interface of magnesium-based implants and bone.
基金We sincerely thank Drs. Tang and Coldren for sharing the microarray datasets. The CD177 mouse strain used for this research project was created from an ES cell clone (12120a-B11) obtained from the KOMP Repository (www.komp.org) and generated by Regeneron Pharmaceuticals, Inc. This work was supported by NIH grant CA158055 (W.Z.) and NIH T32 GM007337 (N.B.). Additionally, W.Z. was supported by depart- mental start up funds, and seed grants from the Department of Pathology at the University of Iowa Carver College of Medicine and from the American Cancer Society. G.H.L. was supported by the National Basic Research Program (973 Program) (Nos. 2015CB964800 and 2014CB964600), the Strategic Priority Research Program of the Chi- nese Academy of Sciences (XDA01020312), the National Natural Science Foundation of China (Grant Nos. 81271266, 31222039, 81330008, 31201111, and 81300677), Beijing Natural Science Foun- dation (7141005), and the Thousand Young Talents program of China, and State Key Laboratory of Drug Research (SIMM1302KF-17). Q.X. was supported by a scholarship from the China Scholarship Council.
文摘Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue in response to infection. Recently, a neutrophil cell surface receptor, CD177, was shown to help mediate neutrophil migration across the endothelium through interactions with PECAMI. We examined a publicly available gene array dataset of CD177 expression from human neutrophils following pulmonary endotoxin instillation. Among all 22,214 genes examined, CD177 mRNA was the most upregu- lated following endotoxin exposure. The high level of CD177 expression is also maintained in airspace neu- trophils, suggesting a potential involvement of CD177 in neutrophil infiltration under infectious diseases. To determine the role of CD177 in neutrophils in vivo, we constructed a CD177-genetic knockout mouse model. The mice with homozygous deletion of CD177 have no discernible phenotype and no significant change in immune cells, other than decreased neutrophil counts in peripheral blood. We examined the role of CD177 in neutrophil accumulation using a skin infection model with Staphylococcus aureus. CD177 deletion reducedneutrophil counts in inflammatory skin caused by S. aureus. Mechanistically we found that CD177 deletion in mouse neutrophils has no significant impact in CXCLI/ KC- or fMLP-induced migration, but led to significant cell death. Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.