To the Editor:Gastric cancer is a highly invasive disease.An estimated 1.09 million cases were diagnosed and 770,000 gastric cancer-related deaths occurred only in 2020.[1]Advanced gastric cancer can no longer be subj...To the Editor:Gastric cancer is a highly invasive disease.An estimated 1.09 million cases were diagnosed and 770,000 gastric cancer-related deaths occurred only in 2020.[1]Advanced gastric cancer can no longer be subjected to surgery and can only be treated with sequential lines of chemotherapy.However,the survival period is usually short.[2]Therefore,it is of utmost importance to identify new and more effective treatments and therapeutic targets to combat gastric cancer.Disc large homolog 7(DLG7)is the microtubule-associated protein encoded by the DLG associated protein 5(DLGAP5)gene,which affects chromosome rearrangement and gene stability[3];thus,its overexpression may cause canceration.Some studies revealed that DLGAP5 is highly expressed in gastric cancer tissues,suggesting that it may also have a role in this disease.However,the role and mechanism of DLGAP5 in gastric cancer are still unclear.[4]Therefore,this study aimed at exploring the role of DLGAP5 in the growth and invasion of gastric cancer as well as the potential use as a therapeutic target to combat this disease.展开更多
基金supported by the Key Technology Projects of Tibet Autonomous Region(No.2015XZ01G22)PostDoctor Research Project,West China Hospital,Sichuan University(No.2018HXBH082)China Postdoctoral Science Foundation(No.2019M653413).
文摘To the Editor:Gastric cancer is a highly invasive disease.An estimated 1.09 million cases were diagnosed and 770,000 gastric cancer-related deaths occurred only in 2020.[1]Advanced gastric cancer can no longer be subjected to surgery and can only be treated with sequential lines of chemotherapy.However,the survival period is usually short.[2]Therefore,it is of utmost importance to identify new and more effective treatments and therapeutic targets to combat gastric cancer.Disc large homolog 7(DLG7)is the microtubule-associated protein encoded by the DLG associated protein 5(DLGAP5)gene,which affects chromosome rearrangement and gene stability[3];thus,its overexpression may cause canceration.Some studies revealed that DLGAP5 is highly expressed in gastric cancer tissues,suggesting that it may also have a role in this disease.However,the role and mechanism of DLGAP5 in gastric cancer are still unclear.[4]Therefore,this study aimed at exploring the role of DLGAP5 in the growth and invasion of gastric cancer as well as the potential use as a therapeutic target to combat this disease.
