Nanocomposites combining magnetic and plasmonic components have received widespread attention in recent years due to their potential applications in biomedical research. Herein, we describe a facile method for growing...Nanocomposites combining magnetic and plasmonic components have received widespread attention in recent years due to their potential applications in biomedical research. Herein, we describe a facile method for growing small iron oxide nanoparticles on various plasmonic core materials with different shapes and surfaces by utilizing a polypyrrole interlayer. By focusing on Au nanorod@polypyrrole@iron oxide （Au NR@PPy@FexO） nanocomposites, we show that these systems exhibit a low r2/rl ratio of 4.8, making them efficient T1 positive contrast-enhancing agents for magnetic resonance imaging （MRI）. Moreover, we show that the nanocomposites are excellent photothermal agents in the second near infrared region, with high photothermal conversion efficiency, reaching up to 46%. In addition, the Au NR@PPy@FexO nanocomposites show very low cytotoxicity. In summary, the present results highlight the great potential of the synthetic method and the nanocomposites developed in this study for T~ MRI and/or infrared thermal imaging-guided photothermal cancer therapeutic applications.展开更多
Real-time tracking drug release behavior is fundamentally important for avoiding adverse effects or unsuccessful treatment in personalizemedical treatment.However,the development of a non-invasive drug reporting platf...Real-time tracking drug release behavior is fundamentally important for avoiding adverse effects or unsuccessful treatment in personalizemedical treatment.However,the development of a non-invasive drug reporting platform still remains challenging.Herein the design of a novelsyn thetic magnetic resonance imaging(MRI)agent for drug release tracking(SMART)is reported,which integrates photothermal core andparamagnetic ion/drug loading shell with a thermal valve in a hybrid structure.Through near-infrared(NIR)-II photothermal effect originatingfrom inner Au-Cu9S5 nanohybrid core,burst release of drugs loaded in the mesoporous silica shell is achieved.The concomitant use of aphase change material not only prevents premature drug release,but also regulates heating effect,keeping local temperature below 45℃,enabling synergistic chemotherapy and mild hyperthermia in vitro and in vivo.Furthermore,the drug release from SMART facilitates protonaccessibility to the paramagnetic ions anchored inside mesopores channels,enhancing Iongitudinal T1 relaxation rate and displaying positivesignal correlation to the amount of released drug,thus allowing norvinvasive real-time monitoring of drug release event.The current studyhighlights the potential of designed MRI nanophores such as SMART for real-time and in-situ monitoring of drug delivery for precisionthera nostic applications.展开更多
基金This work is funded by the ＂Hundred Talents＂ program of Chinese Academy of Sciences, and National Natural Science Foundation of China （Nos. 21175148 and 21473243）.
文摘Nanocomposites combining magnetic and plasmonic components have received widespread attention in recent years due to their potential applications in biomedical research. Herein, we describe a facile method for growing small iron oxide nanoparticles on various plasmonic core materials with different shapes and surfaces by utilizing a polypyrrole interlayer. By focusing on Au nanorod@polypyrrole@iron oxide （Au NR@PPy@FexO） nanocomposites, we show that these systems exhibit a low r2/rl ratio of 4.8, making them efficient T1 positive contrast-enhancing agents for magnetic resonance imaging （MRI）. Moreover, we show that the nanocomposites are excellent photothermal agents in the second near infrared region, with high photothermal conversion efficiency, reaching up to 46%. In addition, the Au NR@PPy@FexO nanocomposites show very low cytotoxicity. In summary, the present results highlight the great potential of the synthetic method and the nanocomposites developed in this study for T~ MRI and/or infrared thermal imaging-guided photothermal cancer therapeutic applications.
基金This work was funded by the National Natural Science Foundation of China(No.21473243)Six Talent Peaks Project in Jiangsu Province(No.SWYY-243).
文摘Real-time tracking drug release behavior is fundamentally important for avoiding adverse effects or unsuccessful treatment in personalizemedical treatment.However,the development of a non-invasive drug reporting platform still remains challenging.Herein the design of a novelsyn thetic magnetic resonance imaging(MRI)agent for drug release tracking(SMART)is reported,which integrates photothermal core andparamagnetic ion/drug loading shell with a thermal valve in a hybrid structure.Through near-infrared(NIR)-II photothermal effect originatingfrom inner Au-Cu9S5 nanohybrid core,burst release of drugs loaded in the mesoporous silica shell is achieved.The concomitant use of aphase change material not only prevents premature drug release,but also regulates heating effect,keeping local temperature below 45℃,enabling synergistic chemotherapy and mild hyperthermia in vitro and in vivo.Furthermore,the drug release from SMART facilitates protonaccessibility to the paramagnetic ions anchored inside mesopores channels,enhancing Iongitudinal T1 relaxation rate and displaying positivesignal correlation to the amount of released drug,thus allowing norvinvasive real-time monitoring of drug release event.The current studyhighlights the potential of designed MRI nanophores such as SMART for real-time and in-situ monitoring of drug delivery for precisionthera nostic applications.
