Increasing evidence suggests that heat shock factor 1 exerts endogenous protective effects on working memory under conditions of chronic psychological stress. However, the precise underlying mechanisms remain poorly u...Increasing evidence suggests that heat shock factor 1 exerts endogenous protective effects on working memory under conditions of chronic psychological stress. However, the precise underlying mechanisms remain poorly understood. This study examined the protective factors affecting working memory in heat shock transcription factor 1 gene knockout mice. The results indicated that the number of correct T maze alternations decreased following mild chronic psychological stress in knockout mice. This change was accompanied by a decrease in neurogenesis and an increase in neuronal apoptosis in the hippocampal dentate gyrus. The number of correct T maze alternations was positively correlated with neurogenesis in hippocampal dentate gyrus, and negatively correlated with neuronal apoptosis. In wild type mice, no significant difference was detected in the number of correct T maze alternations or neuronal apoptosis in hippocampal dentate gyrus. These results indicate that the heat shock factor 1 gene has an endogenous protective role in working memory during mild chronic psychological stress associated with dentate gyrus neuronal apoptosis Moreover, dentate gyrus neurogenesis appears to participate in the protective mechanism.展开更多
1. Introduction Nanoprecipitation strengthening has always been a concern in steel materials, and this approach is one of the most proven and effective strengthening methods [1–3]. However, the increase in strength d...1. Introduction Nanoprecipitation strengthening has always been a concern in steel materials, and this approach is one of the most proven and effective strengthening methods [1–3]. However, the increase in strength due to the nanoprecipitates often corresponds to a decrease in ductility [4,5], and this conflicting relationship between strength and ductility has attracted the attention of researchers,who have sought to find a balance between strength and ductility [6–8].展开更多
基金the National Natural Science Foundation of China, No. 30170326
文摘Increasing evidence suggests that heat shock factor 1 exerts endogenous protective effects on working memory under conditions of chronic psychological stress. However, the precise underlying mechanisms remain poorly understood. This study examined the protective factors affecting working memory in heat shock transcription factor 1 gene knockout mice. The results indicated that the number of correct T maze alternations decreased following mild chronic psychological stress in knockout mice. This change was accompanied by a decrease in neurogenesis and an increase in neuronal apoptosis in the hippocampal dentate gyrus. The number of correct T maze alternations was positively correlated with neurogenesis in hippocampal dentate gyrus, and negatively correlated with neuronal apoptosis. In wild type mice, no significant difference was detected in the number of correct T maze alternations or neuronal apoptosis in hippocampal dentate gyrus. These results indicate that the heat shock factor 1 gene has an endogenous protective role in working memory during mild chronic psychological stress associated with dentate gyrus neuronal apoptosis Moreover, dentate gyrus neurogenesis appears to participate in the protective mechanism.
基金the National Natural Science Foundation of China(Nos.51974032,52174355,51701c021,and 51604034)the Science and Technology Development Program of Jilin Province(No.20190302003GX)。
文摘1. Introduction Nanoprecipitation strengthening has always been a concern in steel materials, and this approach is one of the most proven and effective strengthening methods [1–3]. However, the increase in strength due to the nanoprecipitates often corresponds to a decrease in ductility [4,5], and this conflicting relationship between strength and ductility has attracted the attention of researchers,who have sought to find a balance between strength and ductility [6–8].
