先天性髋关节发育不良(developmental dysplasia of the hip,DDH)是儿童常见的髋部畸形,以髋臼和股骨近端的发育异常和髋关节不稳定为特征[1,2,3]。治疗目标为同心圆复位,即股骨头与髋臼的几何中心力线匹配。18月龄以上的患儿在闭合复...先天性髋关节发育不良(developmental dysplasia of the hip,DDH)是儿童常见的髋部畸形,以髋臼和股骨近端的发育异常和髋关节不稳定为特征[1,2,3]。治疗目标为同心圆复位,即股骨头与髋臼的几何中心力线匹配。18月龄以上的患儿在闭合复位失败后,往往需要切开复位,通过切除冗余关节囊及关节囊内软组织,骨盆截骨和股骨近端去旋转、内翻、短缩截骨,增强关节稳定性[4,5,6]。展开更多
Being one of the most important elements of urban public space, streets have contained rich social lives as well as the social and political connotations in Chinese cities with specific local characteristics, while mo...Being one of the most important elements of urban public space, streets have contained rich social lives as well as the social and political connotations in Chinese cities with specific local characteristics, while most of them have been long neglected in the researches focusing on grand narratives and center-based perspectives. The paper retrospectively analyzes the evolution process of urban streets in China, dividing it into four critical periods. With the perspective of socio-spatial analysis, the unique formation mechanisms of Chinese urban streets are summarized in different contexts including power system, social domain, and living space, thus to provide references for the exploration of street development mode and revitalization mechanism facing the multiple challenges of globalization, modernity, as well as local social and cultural traditions.展开更多
A self-hardening three-dimensional(3D)-porous composite bone graft consisting of 65 wt%hydroxyapatite(HA)and 35 wt%aragonite was fabricated using a 3D-Bioplotter®.New tetracalcium phosphate and dicalcium phosphat...A self-hardening three-dimensional(3D)-porous composite bone graft consisting of 65 wt%hydroxyapatite(HA)and 35 wt%aragonite was fabricated using a 3D-Bioplotter®.New tetracalcium phosphate and dicalcium phosphate anhydrous/aragonite/gelatine paste formulae were developed to overcome the phase separation of the liquid and solid components.The mechanical properties,porosity,height and width stability of the end products were optimised through a systematic analysis of the fabrication processing parameters including printing pressure,printing speed and distance between strands.The resulting 3D-printed bone graft was confirmed to be a mixture of HA and aragonite by X-ray diffraction,Fourier transform infrared spectroscopy and energy dispersive X-ray spectroscopy.The compression strength of HA/aragonite was between 0.56 and 2.49 MPa.Cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay in vitro.The osteogenicity of HA/aragonite was evaluated in vitro by alkaline phosphatase assay using human umbilical cord matrix mesenchymal stem cells,and in vivo by juxtapositional implantation between the tibia and the anterior tibialis muscle in rats.The results showed that the scaffold was not toxic and supported osteogenic differentiation in vitro.HA/aragonite stimulated new bone formation that bridged host bone and intramuscular implants in vivo.We conclude that HA/aragonite is a biodegradable and conductive bone formation biomaterial that stimulates bone regeneration.Since this material is formed near 37°C,it will have great potential for incorporating bioactive molecules to suit personalised application;however,further study of its biodegradation and osteogenic capacity is warranted.The study was approved by the Animal Ethical Committee at Tongji Medical School,Huazhong University of Science and Technology(IACUC No.738)on October 1,2017.展开更多
Sonodynamic therapy for malignant tumours has gained much attention for its deep penetration effect and efficient tumour killing ability.The design,modification,and utilization of sonosensitizers are important aspects...Sonodynamic therapy for malignant tumours has gained much attention for its deep penetration effect and efficient tumour killing ability.The design,modification,and utilization of sonosensitizers are important aspects of sonodynamic therapy.As an essential factor in this process,highly effective sonosensitizers should be developed to facilitate the clinical applications of sonodynamic therapy.This review takes porphyrin-and titanium dioxide(TiO_(2))-based systems as representative organic and inorganic sonosensitizers respectively,and summarizes their characteristics and biological effects as sonodynamic therapy.Upon discovery of novel sonosensitizers,sonodynamic therapy becomes an efficient means of adjuvant therapy for the treatment of malignant tumours.展开更多
文摘先天性髋关节发育不良(developmental dysplasia of the hip,DDH)是儿童常见的髋部畸形,以髋臼和股骨近端的发育异常和髋关节不稳定为特征[1,2,3]。治疗目标为同心圆复位,即股骨头与髋臼的几何中心力线匹配。18月龄以上的患儿在闭合复位失败后,往往需要切开复位,通过切除冗余关节囊及关节囊内软组织,骨盆截骨和股骨近端去旋转、内翻、短缩截骨,增强关节稳定性[4,5,6]。
基金funded by the General Program(51078214)of National Science Foundation of China the Youth Foundation Project(12YJCZH130)of Humanities and Social Science Study of the Ministry of Education
文摘Being one of the most important elements of urban public space, streets have contained rich social lives as well as the social and political connotations in Chinese cities with specific local characteristics, while most of them have been long neglected in the researches focusing on grand narratives and center-based perspectives. The paper retrospectively analyzes the evolution process of urban streets in China, dividing it into four critical periods. With the perspective of socio-spatial analysis, the unique formation mechanisms of Chinese urban streets are summarized in different contexts including power system, social domain, and living space, thus to provide references for the exploration of street development mode and revitalization mechanism facing the multiple challenges of globalization, modernity, as well as local social and cultural traditions.
基金This study was supported by the Wuhan International Collaboration Project of China(No.2017030209020252)Wuhan Science and Technology Project of China(No.2018010401011281).
文摘A self-hardening three-dimensional(3D)-porous composite bone graft consisting of 65 wt%hydroxyapatite(HA)and 35 wt%aragonite was fabricated using a 3D-Bioplotter®.New tetracalcium phosphate and dicalcium phosphate anhydrous/aragonite/gelatine paste formulae were developed to overcome the phase separation of the liquid and solid components.The mechanical properties,porosity,height and width stability of the end products were optimised through a systematic analysis of the fabrication processing parameters including printing pressure,printing speed and distance between strands.The resulting 3D-printed bone graft was confirmed to be a mixture of HA and aragonite by X-ray diffraction,Fourier transform infrared spectroscopy and energy dispersive X-ray spectroscopy.The compression strength of HA/aragonite was between 0.56 and 2.49 MPa.Cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay in vitro.The osteogenicity of HA/aragonite was evaluated in vitro by alkaline phosphatase assay using human umbilical cord matrix mesenchymal stem cells,and in vivo by juxtapositional implantation between the tibia and the anterior tibialis muscle in rats.The results showed that the scaffold was not toxic and supported osteogenic differentiation in vitro.HA/aragonite stimulated new bone formation that bridged host bone and intramuscular implants in vivo.We conclude that HA/aragonite is a biodegradable and conductive bone formation biomaterial that stimulates bone regeneration.Since this material is formed near 37°C,it will have great potential for incorporating bioactive molecules to suit personalised application;however,further study of its biodegradation and osteogenic capacity is warranted.The study was approved by the Animal Ethical Committee at Tongji Medical School,Huazhong University of Science and Technology(IACUC No.738)on October 1,2017.
基金This work was supported by the National Key Research and Development Program of China(No.2016YFC1100100)the Singapore National Research Foundation Investigatorship(No.NRF-NRFI2018-03).
文摘Sonodynamic therapy for malignant tumours has gained much attention for its deep penetration effect and efficient tumour killing ability.The design,modification,and utilization of sonosensitizers are important aspects of sonodynamic therapy.As an essential factor in this process,highly effective sonosensitizers should be developed to facilitate the clinical applications of sonodynamic therapy.This review takes porphyrin-and titanium dioxide(TiO_(2))-based systems as representative organic and inorganic sonosensitizers respectively,and summarizes their characteristics and biological effects as sonodynamic therapy.Upon discovery of novel sonosensitizers,sonodynamic therapy becomes an efficient means of adjuvant therapy for the treatment of malignant tumours.
