Background:Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes;however,the complications that emerge from tissue expansion hinder repair.Infection is considered a major complicati...Background:Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes;however,the complications that emerge from tissue expansion hinder repair.Infection is considered a major complication of tissue expansion.This study aimed to analyze the perioperative risk factors for expander infection.Methods:A large,retrospective,single-institution observational study was carried out over a 10-year period.The study enrolled consecutive patients who had undergone tissue expansion for scar reconstruction.Demographics,etiological data,expander-related characteristics and postoperative infection were assessed.Univariate and multivariate logistic regression analysis were performed to identify risk factors for expander infection.In addition,we conducted a sensitivity analysis for treatment failure caused by infection as an outcome.Results:A total of 2374 expanders and 148 cases of expander infection were assessed.Treatment failure caused by infection occurred in 14 expanders.Multivariate logistic regression analysis identified that disease duration of≤1 year(odds ratio(OR),2.07;p<0.001),larger volume of expander(200–400ml vs<200 ml;OR,1.74;p=0.032;>400ml vs<200 ml;OR,1.76;p=0.049),limb location(OR,2.22;p=0.023)and hematoma evacuation(OR,2.17;p=0.049)were associated with a high likelihood of expander infection.Disease duration of≤1 year(OR,3.88;p=0.015)and hematoma evacuation(OR,10.35;p=0.001)were so related to high risk of treatment failure.Conclusions:The rate of expander infection in patients undergoing scar reconstruction was 6.2%.Disease duration of<1 year,expander volume of>200 ml,limb location and postoperative hematoma evacuation were independent risk factors for expander infection.展开更多
基金Funding from the National Natural Science Foundation of China(81671925,81971851)the Shaanxi Province Key R&D Program Project(2018ZDXM-SF-081)the Discipline Promotion Project of Xijing Hospital(XJZT19D03)were received for this study.
文摘Background:Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes;however,the complications that emerge from tissue expansion hinder repair.Infection is considered a major complication of tissue expansion.This study aimed to analyze the perioperative risk factors for expander infection.Methods:A large,retrospective,single-institution observational study was carried out over a 10-year period.The study enrolled consecutive patients who had undergone tissue expansion for scar reconstruction.Demographics,etiological data,expander-related characteristics and postoperative infection were assessed.Univariate and multivariate logistic regression analysis were performed to identify risk factors for expander infection.In addition,we conducted a sensitivity analysis for treatment failure caused by infection as an outcome.Results:A total of 2374 expanders and 148 cases of expander infection were assessed.Treatment failure caused by infection occurred in 14 expanders.Multivariate logistic regression analysis identified that disease duration of≤1 year(odds ratio(OR),2.07;p<0.001),larger volume of expander(200–400ml vs<200 ml;OR,1.74;p=0.032;>400ml vs<200 ml;OR,1.76;p=0.049),limb location(OR,2.22;p=0.023)and hematoma evacuation(OR,2.17;p=0.049)were associated with a high likelihood of expander infection.Disease duration of≤1 year(OR,3.88;p=0.015)and hematoma evacuation(OR,10.35;p=0.001)were so related to high risk of treatment failure.Conclusions:The rate of expander infection in patients undergoing scar reconstruction was 6.2%.Disease duration of<1 year,expander volume of>200 ml,limb location and postoperative hematoma evacuation were independent risk factors for expander infection.
