Cancer stem cells(CSCs),a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation,lead to tumorigenesis,metastasis,and maintain tumor heterogeneity.Cancer continues to be a ...Cancer stem cells(CSCs),a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation,lead to tumorigenesis,metastasis,and maintain tumor heterogeneity.Cancer continues to be a significant global disease burden.In the past,surgery,radiotherapy,and chemotherapy were the main cancer treatments.The technology of cancer treatments continues to develop and advance,and the emergence of targeted therapy,and immunotherapy provides more options for patients to a certain extent.However,the limitations of efficacy and treatment resistance are still inevitable.Our review begins with a brief introduction of the historical discoveries,original hypotheses,and pathways that regulate CSCs,such as WNT/β-Catenin,hedgehog,Notch,NFkB,JAK/STAT,TGF-β,PI3K/AKT,PPAR pathway,and their crosstalk.We focus on the role of CSCs in various therapeutic outcomes and resistance,including how the treatments affect the content of CSCs and the alteration of related molecules,CSCs-mediated therapeutic resistance,and the clinical value of targeting CSCs in patients with refractory,progressed or advanced tumors.In summary,CSCs affect therapeutic efficacy,and the treatment method of targeting CSCs is stll difficult to determine.Clarifying regulatory mechanisms and targeting biomarkers of CSCs is currently the mainstream idea.展开更多
基金This work was supported by Advanced Lung Cancer Targeted Therapy Research Foundation of China(CTONG-YC20210303)Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province(CXPJJH121005-01)+2 种基金National Multidisciplinary Cooperative Diagnosis and Treatment Capacity(lung cancer z027002)Health Research Project of Hunan Provincial Health Commission(W20242005)Postdoctoral Fellowship Programof CPSF(GZC20233187).
文摘Cancer stem cells(CSCs),a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation,lead to tumorigenesis,metastasis,and maintain tumor heterogeneity.Cancer continues to be a significant global disease burden.In the past,surgery,radiotherapy,and chemotherapy were the main cancer treatments.The technology of cancer treatments continues to develop and advance,and the emergence of targeted therapy,and immunotherapy provides more options for patients to a certain extent.However,the limitations of efficacy and treatment resistance are still inevitable.Our review begins with a brief introduction of the historical discoveries,original hypotheses,and pathways that regulate CSCs,such as WNT/β-Catenin,hedgehog,Notch,NFkB,JAK/STAT,TGF-β,PI3K/AKT,PPAR pathway,and their crosstalk.We focus on the role of CSCs in various therapeutic outcomes and resistance,including how the treatments affect the content of CSCs and the alteration of related molecules,CSCs-mediated therapeutic resistance,and the clinical value of targeting CSCs in patients with refractory,progressed or advanced tumors.In summary,CSCs affect therapeutic efficacy,and the treatment method of targeting CSCs is stll difficult to determine.Clarifying regulatory mechanisms and targeting biomarkers of CSCs is currently the mainstream idea.
