Teaching Research and Reform of Higher Vocational Medical Education in Guizhou Province of China

With the development of Guizhou’s economy and society, higher vocational medical education in Guizhou has developed rapidly, making it its mission to cultivate practical and skilled talents oriented to the grassroots and serving for frontline. However, due to the social environment, policy environment and insufficient funding, many difficulties and problems are faced. It is necessary to have a unified management throughout the province, rationally lay out higher vocational colleges and specialties, and promote the healthy and rapid development of medical higher vocational education in Guizhou with advanced concepts, proper policies, and sufficient funds in place, making higher vocational medical education in Guizhou enter a benign development period.

The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive decline,accompanied by amyloid-β(Aβ)overload and hyperphosphorylated tau accumulation in the brain.Synaptic dysfunction,an important pathological hallmark in AD;is recognized as the main cause of the cognitive impairments.Accumulating evidence suggests that synaptic dysfunction could be an early pathological event in AD.Pathological tau,which is detached from axonal microtubules and mislocalized into pre-and postsynaptic neuronal compartments,is suggested to induce synaptic dysfunction in several ways,including reducing mobility and release of presynaptic vesicles,decreasing glutamatergic receptors,impairing the maturation of dendritic spines at postsynaptic terminals,disrupting mitochondrial transport and function in synapses,and promoting the phagocytosis of synapses by microglia.Here,we review the current understanding of how pathological tau mediates synaptic dysfunction and contributes to cognitive decline in AD.We propose that elucidating the mechanism by which pathological tau impairs synaptic function is essential for exploring novel therapeutic strategies for AD.

Gene frequency of five genetic characteristics in six nationalities in Southern Guizhou Province,China

Five characteristics(hair forms,nasal profile,nostril forms,mongoloid fold and upper eyelid fold)were respectively investigated in six nationalities,including the Buyi,Miao,Shui,Maonan,Dong,and Han nationalities in Southern Guizhou,China.The gene frequencies of five characteristics in the six nationalities were estimated and compared.The results indicated that:(1)for hair forms and nasal profile,the frequency of the dominant gene was lower than that of their recessive gene,but the opposite was true for nostril forms.(2)Among different nationalities,the difference of gene frequency of the mongoloid fold,nasal profile,hair forms and upper eyelid fold was quite significant,which was followed by that of nostril forms.