The induction of MT（metallothionein） by Cd（Ⅱ） and Zn（Ⅱ） in renal proximal tubule cells （LLC-PKI） and the effects of simultaneous administration of Cd（Ⅱ） and Zn（Ⅱ） on MT induction were discussed. The tw...The induction of MT（metallothionein） by Cd（Ⅱ） and Zn（Ⅱ） in renal proximal tubule cells （LLC-PKI） and the effects of simultaneous administration of Cd（Ⅱ） and Zn（Ⅱ） on MT induction were discussed. The two metals administered together are able to induce MT to almost 40/ag MT/mg protein. The additive production of MT may be due to two different effects by Cd（Ⅱ） and Zn（Ⅱ） on the activation of MT transcription. The experiments of simultaneous administration of Cd（Ⅱ） and Zn（Ⅱ） to the renal proximal tubule cells demonstrated the interaction of these metals, MT induction and proximal tubule toxicity.展开更多
文摘The induction of MT（metallothionein） by Cd（Ⅱ） and Zn（Ⅱ） in renal proximal tubule cells （LLC-PKI） and the effects of simultaneous administration of Cd（Ⅱ） and Zn（Ⅱ） on MT induction were discussed. The two metals administered together are able to induce MT to almost 40/ag MT/mg protein. The additive production of MT may be due to two different effects by Cd（Ⅱ） and Zn（Ⅱ） on the activation of MT transcription. The experiments of simultaneous administration of Cd（Ⅱ） and Zn（Ⅱ） to the renal proximal tubule cells demonstrated the interaction of these metals, MT induction and proximal tubule toxicity.
