Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer ce...Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure–activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.展开更多
A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,toge...A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,together with 11 known compounds（2- 12）.The structure and absolute configuration of 1 was determined by means of NMR and CD analysis.Compound 3 shows selective cytotoxic activity on human colon cancer cell HCT-8（IC_（50） = 1.78μmol/L） by MTT test in vitro.Other compounds show no such activities（IC_（50）〉10μmol/L）.展开更多
文摘Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure–activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.
基金Financial support from the National Science and Technology Project of China(No2009ZX09311-004)the Natural Science Foundation of China(No201072234)
文摘A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,together with 11 known compounds（2- 12）.The structure and absolute configuration of 1 was determined by means of NMR and CD analysis.Compound 3 shows selective cytotoxic activity on human colon cancer cell HCT-8（IC_（50） = 1.78μmol/L） by MTT test in vitro.Other compounds show no such activities（IC_（50）〉10μmol/L）.
