The cytosolic liver-specific growth factor-hepatic stimulator substance (HSS) has been shown to be able to amplify the rat hepatocyte proliferation responded to EGF. In order to get more insight into the mechanism, th...The cytosolic liver-specific growth factor-hepatic stimulator substance (HSS) has been shown to be able to amplify the rat hepatocyte proliferation responded to EGF. In order to get more insight into the mechanism, the regulatory effect of HSS on EGF-receptor(EGF-R) and the receptor phosphorylation at molecular level was studied. HSS partially purified from weanling rat liver was given to cultured hepatocytes and its influence on EGF-R specific binding and internalization as well as mRNA expression were investigated. The results showed that preincubation of hepatocytes with HSS could lead to an increase in [125I]-EGF binding to its receptors and inhibit EGFinduced receptor down-regulation. Furthermore, the overexpression of EGF-R mRNA stimulated by HSS was seen during 2-12 h after the incubation. Additionally, it was demonstrated with human hepatoma sMMC-7721 cells in Western blot that the EGF-R expression and the receptor autophosphorylation were increased with dose/timedependency after HSS treatment. These results strongly suggest that the mechanism of HSS action on hepatocyte growth might be related to its modulation on EGF-R and receptor-mediated signaling transduction.展开更多
In this paper, we mainly discuss the normality of two families of functions concerning shared values and proved： Let F and G be two families of functions meromorphic on a domain D C C, a1, a2, a3, a4 be four distinct...In this paper, we mainly discuss the normality of two families of functions concerning shared values and proved： Let F and G be two families of functions meromorphic on a domain D C C, a1, a2, a3, a4 be four distinct finite complex numbers. If G is normal, and for every f 9~, there exists g C G such that f（z） and g（z） share the values a1, a2, a3, a4, then F is normal on D.展开更多
Let F be a family of functions holomorphic on a domain D C C. Let k ≥ 2 be an integer and let h be a holomorphic function on D, all of whose zeros have multiplicity at most k- 1, such that h（z） has no common zeros ...Let F be a family of functions holomorphic on a domain D C C. Let k ≥ 2 be an integer and let h be a holomorphic function on D, all of whose zeros have multiplicity at most k- 1, such that h（z） has no common zeros with any f∈F. Assume also that the following two conditions hold for every f ∈F ：（a） f（z） = 0 == f （z） = h（z）; and （b） y（z） = h（z） == ｜f（k）（z）｜ ≤ c, where c is a constant.Then F is normal on D.展开更多
We prove that ifD is a domain in C,α 〉 1 and C 〉 0,then the family F of functions f meromorphic in D such that ｜f′（z）｜/1 ＋ ｜f（z）｜α 〉 C for every z ∈ D is normal in D.For α = 1,the same assumptions imp...We prove that ifD is a domain in C,α 〉 1 and C 〉 0,then the family F of functions f meromorphic in D such that ｜f′（z）｜/1 ＋ ｜f（z）｜α 〉 C for every z ∈ D is normal in D.For α = 1,the same assumptions imply quasi-normality but not necessarily normality.展开更多
文摘The cytosolic liver-specific growth factor-hepatic stimulator substance (HSS) has been shown to be able to amplify the rat hepatocyte proliferation responded to EGF. In order to get more insight into the mechanism, the regulatory effect of HSS on EGF-receptor(EGF-R) and the receptor phosphorylation at molecular level was studied. HSS partially purified from weanling rat liver was given to cultured hepatocytes and its influence on EGF-R specific binding and internalization as well as mRNA expression were investigated. The results showed that preincubation of hepatocytes with HSS could lead to an increase in [125I]-EGF binding to its receptors and inhibit EGFinduced receptor down-regulation. Furthermore, the overexpression of EGF-R mRNA stimulated by HSS was seen during 2-12 h after the incubation. Additionally, it was demonstrated with human hepatoma sMMC-7721 cells in Western blot that the EGF-R expression and the receptor autophosphorylation were increased with dose/timedependency after HSS treatment. These results strongly suggest that the mechanism of HSS action on hepatocyte growth might be related to its modulation on EGF-R and receptor-mediated signaling transduction.
基金Supported by National Natural Science Foundation of China(Grant No.11071074)supported by Outstanding Youth Foundation of Shanghai(Grant No.slg10015)
文摘In this paper, we mainly discuss the normality of two families of functions concerning shared values and proved： Let F and G be two families of functions meromorphic on a domain D C C, a1, a2, a3, a4 be four distinct finite complex numbers. If G is normal, and for every f 9~, there exists g C G such that f（z） and g（z） share the values a1, a2, a3, a4, then F is normal on D.
基金The first author is supported by the Gelbart Research Institute for Mathematical Sciences and by National Natural Science Foundation of China （Grant No. 10671067） the second author is supported by the Israel Science Foundation （Grant No. 395107）
文摘Let F be a family of functions holomorphic on a domain D C C. Let k ≥ 2 be an integer and let h be a holomorphic function on D, all of whose zeros have multiplicity at most k- 1, such that h（z） has no common zeros with any f∈F. Assume also that the following two conditions hold for every f ∈F ：（a） f（z） = 0 == f （z） = h（z）; and （b） y（z） = h（z） == ｜f（k）（z）｜ ≤ c, where c is a constant.Then F is normal on D.
基金supported by National Natural Science Foundation of China(Grant No.11071074)the Tianyuan Special Funds of the National Natural Science Foundation of China(Grant No.11226095)+1 种基金Outstanding Youth Foundation of Shanghai(Grant No.slg10015)supported by the Israel Science Foundation(Grant No.395/07)
文摘We prove that ifD is a domain in C,α 〉 1 and C 〉 0,then the family F of functions f meromorphic in D such that ｜f′（z）｜/1 ＋ ｜f（z）｜α 〉 C for every z ∈ D is normal in D.For α = 1,the same assumptions imply quasi-normality but not necessarily normality.
