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Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study 被引量:2
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作者 Xinyi Jin Yilin Chen +8 位作者 Hongliang Feng Mingqing Zhou Joey W.Y.Chang Yaping Liu Alice Pik Shan Kong xiao tan Yun-Kwok Wing Yannis Yan Liang Jihui Zhang 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第2期222-232,共11页
Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a populat... Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort study.Methods:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK Biobank.Sleep duration(short:<6 h/day;normal:6-8 h/day;long:>8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and 2015.PA was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death registries.Results:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were documented.Compared with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes risk.This increased risk among short sleepers seems to be protected against by PA.Compared with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did not.Conclusion:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk. 展开更多
关键词 Light physical activity Sleep duration Triaxial accelerometer Type 2 diabetes UK Biobank
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环丙氟虫胺对水稻二化螟的毒力和田间防效评价
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作者 周丽琪 相君成 +2 位作者 庄彩霞 肖坦 倪珏萍 《世界农药》 CAS 2024年第10期31-36,共6页
为了测试并评价环丙氟虫胺对抗性地区水稻二化螟(Chilo suppressalis)的室内和田间效果,为抗性二化螟的化学防治提供科学依据。以环丙氟虫胺、氯虫苯甲酰胺和阿维菌素为供试药剂,室内采用稻茎浸渍法测试了3省12地二化螟的活性,田间采用... 为了测试并评价环丙氟虫胺对抗性地区水稻二化螟(Chilo suppressalis)的室内和田间效果,为抗性二化螟的化学防治提供科学依据。以环丙氟虫胺、氯虫苯甲酰胺和阿维菌素为供试药剂,室内采用稻茎浸渍法测试了3省12地二化螟的活性,田间采用喷雾法测试了3省3地的防治效果。试验结果表明:与二化螟敏感种群相比,环丙氟虫胺对二化螟的LC_(50)为0.332~0.897 mg/L、抗性倍数为1.6~4.2倍,氯虫苯甲酰胺LC_(50)为62.407~>500 mg/L、抗性倍数为14.2~>114.1倍,阿维菌素LC_(50)为0.887~29.561 mg/L、抗性倍数为4.4~145.6倍。20%环丙氟虫胺SC以有效成分30~60 g/hm^(2)剂量进行均匀喷雾处理,药后21 d时,对二化螟的田间防效为81.54%~98.60%,200 g/L氯虫苯甲酰胺SC在有效成分30 g/hm^(2)剂量下防效14.01%~39.24%、5%阿维菌素EC在有效成分150 g/hm^(2)剂量下防效80.47%~97.68%。环丙氟虫胺对不同地区的二化螟均具有优秀且稳定的活性表现,在有效成分60 g/hm^(2)剂量下,对不同抗性水稻二化螟的药后21 d防效在90%以上。环丙氟虫胺与氯虫苯甲酰胺、阿维菌素无交互抗性,在化学防治抗性二化螟方面,环丙氟虫胺是替代氯虫苯甲酰胺和阿维菌素的理想产品,具有良好的应用价值。 展开更多
关键词 二化螟 环丙氟虫胺 毒力 交互抗性 田间防效
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环丙氟虫胺对黄曲条跳甲室内活性及田间防效
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作者 肖坦 赵莉 +3 位作者 相君成 张颂函 杨燕玲 倪珏萍 《世界农药》 CAS 2024年第5期30-33,48,共5页
为测试并评价环丙氟虫胺对黄曲条跳甲的室内活性及田间防效,以溴虫氟苯双酰胺和哒螨灵作对照药剂,室内活性采用浸叶法,田间防效采用小区喷雾试验法。试验结果表明,环丙氟虫胺对黄曲条跳甲的室内活性最高,LC50值为0.58 mg/L,优于溴虫氟... 为测试并评价环丙氟虫胺对黄曲条跳甲的室内活性及田间防效,以溴虫氟苯双酰胺和哒螨灵作对照药剂,室内活性采用浸叶法,田间防效采用小区喷雾试验法。试验结果表明,环丙氟虫胺对黄曲条跳甲的室内活性最高,LC50值为0.58 mg/L,优于溴虫氟苯双酰胺(1.48 mg/L)和哒螨灵(258.02 mg/L);在2021—2023年的3年9地田间试验中,10%环丙氟虫胺可分散液剂15~30 g a.i./hm^(2)剂量下,药后7 d对黄曲条跳甲的平均防效为87.62%~93.54%,与100 g/L溴虫氟苯双酰胺SC在22.5 g a.i./hm^(2)剂量下的防效88.15%相当,显著优于15%哒螨灵EC在225 g a.i./hm^(2)剂量下的防效53.36%。因此,10%环丙氟虫胺可分散液剂可作为防治黄曲条跳甲的有效药剂,推荐剂量为15~22.5 g a.i./hm^(2),在黄曲条跳甲发生初期均匀喷雾防治,且对作物安全。 展开更多
关键词 环丙氟虫胺 黄曲条跳甲 室内活性 田间防效
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Effect of aerobic exercise on insulin resistance and centra1 adiposity disappeared after the discontinuation of intervention in overweight women 被引量:1
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作者 Shenglong Le Lijuan Mao +4 位作者 Dajiang Lu Yifan Yang xiao tan Petri Wiklund Sulin Cheng 《Journal of Sport and Health Science》 SCIE 2016年第2期166-170,共5页
Purpose: This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance (HOMA-IR) are maintained after discontinuation of intervention in the overweight/obese (OWOB) women... Purpose: This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance (HOMA-IR) are maintained after discontinuation of intervention in the overweight/obese (OWOB) women. Methods: The study subjects were from 2 independent studies with similar aerobic exercise (AE) intervention programs. In study I, I50WOB postmenopausal women with pre-diabetes (body mass index, BMI = 24-33 kg/m2, aged 52-65 years) completed an 8-month exercise intervention and were followed for 2 years after the intervention. In study lI, 12 OWOB (BM1 = 25-35 kg/m2, aged 30-50 years) premenopausal women participated in a 6-week AE and were followed for 4 years after the intervention. The exercise program consisted of progressive AE with intensity of 60%-75% of initial fitness level, 30-60 min/time and 3-5 times/week. Fat mass (FM) was assessed by Dual Energy X-ray Absorptiometry (DXA Prodigy; study I) or bioelectrical impedance device (Inbody 720; study II). Plasma glucose and insulin were assessed by chemiluminescent immunoassay and HOMA-IR was calculated. Results: Both 8-month and 6-week moderate AE were effective in reducing HOMA-IR (-18.9%, p = 0.012 and -26.7%, p = 0.046, respectively), and 8-month AE reduced FM at upper abdominal region (-6.2%, p = 0.021). However, these improvements were not maintained in either study at the follow-up. Conclusion: The AE program used in these studies was effective to reduce insulin resistance and/or FM in central body region among overweight and obese women. However, when exercise intervention was discontinued, the beneficial effects following both short- and long-term intervention disappeared. Thus maintaining exercise seems to be required if one wants to reap the benefits of exercise in the long-term. 展开更多
关键词 Exercise intervention Obesity POSTMENOPAUSE PREMENOPAUSE RELAPSE
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Key physiological traits and chemical properties of extracellular polymeric substances determining colony formation in a cyanobacterium 被引量:1
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作者 Zhipeng DUAN xiao tan Qingfei ZENG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2022年第5期1720-1731,共12页
Colony formation of cyanobacteria is crucial for the formation of surface blooms in lakes.However,the underlying mechanisms of colony formation involving in physiological and cell surface characteristics remain to not... Colony formation of cyanobacteria is crucial for the formation of surface blooms in lakes.However,the underlying mechanisms of colony formation involving in physiological and cell surface characteristics remain to not well be established.Six cyanobacterial Microcystis strains(including both unicellular and colonial ones)were employed to estimate the influences of their physiological traits and the composition of extracellular polymeric substances(EPS)on colony or aggregate formation.Results show that raising the number of the photosynthetic reaction center and light-harvesting antenna in the PSII and reducing the growth rate were the major physiological strategies of Microcystis to produce excess EPS enhancing colony formation.Tightly bound EPS(T-EPS)was responsible for colony formation,which approximately accounted for 50%of the total amount of EPS.Five fluorescent components(protein-,tryptophan-,and tyrosine-like components and two humic-like components)were found in the T-EPS,although the amounts of these components varied with strains.Importantly,colonial strains contained much higher tyrosine-like substances than unicellular ones.We suggest that tyrosine-like substances might serve as a crosslinking agent to connect other polymers in EPS(e.g.,proteins or polysaccharides)for colony formation.Our findings identified key physiological traits and chemical components of EPS for colony formation in Microcystis,which can contribute to a better understanding on the formation of Microcystis blooms. 展开更多
关键词 colony formation physiological properties extracellular polymeric substances(EPS)composition cyanobacterial blooms
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Extraction of Antioxidant Total Phenol from Lees of Xiaoqu Spirits
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作者 Xinzhi Cao Fang Liu +2 位作者 Jia Liu xiao tan Linsheng Ren 《Food and Nutrition Sciences》 2015年第11期1022-1028,共7页
By the Soxhlet extraction, ethanol is used as extraction solvent of lees to determinate the total phenol content of Xiaoqu spirits lees. Folin-phenol method is handled to extract and to determine the reducing ability ... By the Soxhlet extraction, ethanol is used as extraction solvent of lees to determinate the total phenol content of Xiaoqu spirits lees. Folin-phenol method is handled to extract and to determine the reducing ability of extraction. The total phenolic content in the most suitable condition is determinated by the Folin-phenol method and the optimum extraction technological condition of total phenol is determinated by the experiment. The experimental results show that the optimization conditions of the determination methods of total phenolic content are determined by 3.5 mL for the Folin phenol reagent, 1:1 for the 10% Na2CO3 ratio and 30 min for the chromogenic reaction at room temperature. The optimum extraction technological condition of total phenol from lees is as following: solid-liquid ratio 1:12, ethanol concentration 100%, extraction temperature 80℃, extraction time 10 h. 展开更多
关键词 Xiaoqu SPIRITS LEES EXTRACTION TOTAL PHENOLS
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苯基和苯甲酰基硫脲在盐酸中的缓蚀性能和机理分析 被引量:3
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作者 余意 刁欢 +4 位作者 王恒 肖谭 曾春珉 王应好 张健 《油田化学》 CAS CSCD 北大核心 2023年第1期117-122,136,共7页
为了深入理解硫脲基酸化缓蚀剂的缓蚀作用机制,提高硫脲基缓蚀剂在酸化开发过程中的应用效果,利用腐蚀失重实验、扫描电子显微镜、量子化学计算研究了两种硫脲衍生物苯基硫脲(PHTU)和苯甲酰基硫脲(BOTU)在15%HCl溶液中对20#钢的缓蚀性... 为了深入理解硫脲基酸化缓蚀剂的缓蚀作用机制,提高硫脲基缓蚀剂在酸化开发过程中的应用效果,利用腐蚀失重实验、扫描电子显微镜、量子化学计算研究了两种硫脲衍生物苯基硫脲(PHTU)和苯甲酰基硫脲(BOTU)在15%HCl溶液中对20#钢的缓蚀性能和缓蚀机理。结果表明,PHTU和BOTU对20#钢在15%HCl溶液中均有较好的缓蚀效果。加量为2 mmol/L时,钢片表面形成的较为致密完整的腐蚀产物可抑制腐蚀性介质与钢基体的接触,缓蚀率可达83%以上,且由于BOTU分子中C=O双键的存在,BOTU的缓蚀性能优于PHTU。PHTU和BOTU在钢表面的吸附均符合Langmuir吸附模型,吸附方式为物理吸附和化学吸附共存的混合吸附。量子化学计算结果表明,缓蚀剂分子中的反应活性位点主要分布在C=S双键、C—N键及BOTU的C=O双键上。其中,N原子被酸液质子化后可与钢表面通过静电引力形成物理吸附;高电子云密度的C=S键、C=O键及苯基可提供电子与铁原子的空d轨道,通过配位和反馈键形成化学吸附,进而稳定吸附在金属表面形成保护膜,抑制腐蚀进程。 展开更多
关键词 硫脲衍生物 缓蚀剂 缓蚀性能 量子化学计算 缓蚀机理
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Symmetrical femtosecond laser arc incision in correcting corneal astigmatism in cataract patients 被引量:2
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作者 Zun-Xia Hu Jing Sima +8 位作者 Jia-Guo Cao Yan Ke Ying-Ying Zhang Qiong-Tian Guo Yu-Ping He Hong-Xia Liao xiao tan Bo Qin Li Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第12期1996-2003,共8页
AIM:To evaluate the effect of symmetrical arc incision correcting corneal astigmatism in femtosecond laserassisted phacoemulsification(FLACS).METHODS:This study enrolled patients with cataract combined with regular co... AIM:To evaluate the effect of symmetrical arc incision correcting corneal astigmatism in femtosecond laserassisted phacoemulsification(FLACS).METHODS:This study enrolled patients with cataract combined with regular corneal astigmatism of>0.75 D,who underwent FLACS.Symmetrical arc incision was set at 8 mm diameter and 85%depth.The follow-up time was 3-24mo(4.92±3.49mo).Pentacam recorded the corneal astigmatism and higher-order aberration at pre-operation and post-operation.The changes in corneal astigmatism were analyzed by Alpins method.The correlation of astigmatism type,age,corneal horizontal diameter,corneal thickness,arc incision length,and correction index(CI)was analyzed,and the residual corneal astigmatism was compared with the residual whole eye astigmatism.RESULTS:Totally 79 patients(102 eyes)were enrolled,10 patients had corneal epithelial injury,1 patient occurred corneal epithelial hyperplasia.The corneal astigmatism was 1.23±0.38 D pre-operation,and decreased to 0.76±0.39 D post-operation(t=10.146,P=0.000).Corneal high-order aberration was 0.17±0.08μm pre-operation and 0.24±0.11μm post-operation(t=-5.186,P=0.000).The residual corneal astigmatism and residual whole eye astigmatism were no significant difference(t=-0.347,P=0.729).Using Alpin’s method,the following were determined:target-induced astigmatism(TIA)=1.23±0.38 D,surgeryinduced astigmatism(SIA)=0.77±0.45 D,difference vector(DV)=0.77±0.39 D,and CI=0.54±0.28.Age,astigmatism size,corneal horizontal diameter,corneal thickness,and arc incision length were not correlated with CI.The CI for against the rule astigmatism(ATR)was better than that for with the rule astigmatism(WTR;P=0.001).CONCLUSION:Femtosecond laser-assisted astigmatic keratotomy has better CI of ATR,but increase higher-order corneal aberration.CI is not ideal,it’s not a perfect choice if we pursue ideal correction effect. 展开更多
关键词 femtosecond laser arc incision keratotomy ASTIGMATISM CATARACT higher-order aberrations
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Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality:A prospective cohort study 被引量:1
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作者 Ying Sun Chi Chen +6 位作者 Yuetian Yu Haojie Zhang xiao tan Jihui Zhang Lu Qi Yingli Lu Ningjian Wang 《Journal of Sport and Health Science》 SCIE CSCD 2023年第3期287-294,共8页
Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing dementia.We examined th... Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing dementia.We examined the association between leisure-time sedentary behavior(SB)and the risk of dementia incidence and mortality.We further quantified the effect on dementia risk of replacing sedentary time with an equal amount of time spent on different physical activities.Methods:In the UK Biobank,484,169 participants(mean age=56.5 years;45.2%men)free of dementia were followed from baseline(2006-2010)through July 30,2021.A standard questionnaire measured individual leisure-time SB(watching TV,computer use,and driving)and PA(walking for pleasure,light and heavy do-it-yourself activity,strenuous sports,and other exercise)frequency and duration in the 4 weeks prior to evaluation.Apolipoprotein E(APOE)genotype data were available for a subset of 397,519(82.1%)individuals.A Cox proportional hazard model and an isotemporal substitution model were used in this study.Results:During a median 12.4 years of follow-up,6904 all-cause dementia cases and 2115 deaths from dementia were recorded.In comparison to participants with leisure-time SB<5 h/day,the hazard ratio((HR),95%confidence interval(95%CI))of dementia incidence was 1.07(1.02-1.13)for 5-8 h/day and 1.25(1.13-1.38)for>8 h/day,and the HR of dementia mortality was 1.35(1.12-1.61)for>8 h/day.A 1 standard deviation increment of sedentary time(2.33 h/day)was strongly associated with a higher incidence of dementia and mortality(HR=1.06,95%CI:1.03-1.08 and HR=1.07,95%CI:1.03-1.12,respectively).The association between sedentary time and the risk of developing dementia was more profound in subjects<60 years than in those>60 years(HR=1.26,95%CI:1.00-1.58 vs.HR=1.21,95%CI:1.08-1.35 in>8 h/day,p for interaction=0.013).Replacing 30 min/day of leisure sedentary time with an equal time spent in total PA was associated with a6%decreased risk and 9%decreased mortality from dementia,with exercise(e.g.,swimming,cycling,aerobics,bowling)showing the strongest benefit(HR=0.82,95%CI:0.78-0.86 and HR=0.79,95%CI:0.72-0.86).Compared with APOEε4 noncarriers,APOEε4 carriers are more likely to see a decrease in Alzheimer’s disease incidence and mortality when PA is substituted for SB.Conclusion:Leisure-time SB was positively associated with the risk of dementia incidence and mortality.Replacing sedentary time with equal time spent doing PA may be associated with a significant reduction in dementia incidence and mortality risk. 展开更多
关键词 Alzheimer's disease Apolipoprotein E DEMENTIA Isotemporal substitution model Physical activity Sedentary behavior
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一期患侧朝上斜仰截石位与分期截石位输尿管软镜治疗肾结石的疗效比较
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作者 曾智辉 林超禄 +2 位作者 廖柏兰 肖锬 吴钦福 《中外医疗》 2023年第6期83-86,95,共5页
目的 探讨一期患侧朝上斜仰截石位与分期截石位输尿管软镜治疗肾结石的疗效。方法 方便选择2020年5月—2021年10月于龙岩市第一医院接受治疗的54例肾结石患者为对象,根据手术方式不同分为一期斜仰截石位手术组(n=32)和分期截石位手术组(... 目的 探讨一期患侧朝上斜仰截石位与分期截石位输尿管软镜治疗肾结石的疗效。方法 方便选择2020年5月—2021年10月于龙岩市第一医院接受治疗的54例肾结石患者为对象,根据手术方式不同分为一期斜仰截石位手术组(n=32)和分期截石位手术组(n=22)。一期斜仰截石位手术组予以一期患侧朝上斜仰截石位输尿管软镜钬激光碎石术(flexible ureteroscopic lithotripsy,FURL)治疗,分期截石位手术组给予分期截石位FURL治疗,治疗后评估两组临床疗效,比较两组手术时间、住院时间、结石清除率及术后并发症发生情况。结果 两组患者手术均顺利完成,并未出现严重并发症。两组手术时间比较,差异无统计学意义(P>0.05)。两组住院时间比较,差异有统计学意义(P<0.05)。一期斜仰截石位手术组结石清除率(93.75%)高于分期截石位手术组(68.18%),一期斜仰截石位手术组并发症发生率(3.13%)显著低于分期截石位手术组(27.27%),差异有统计学意义(χ^(2)=4.434、4.768,P<0.05)。结论 临床治疗肾结石采用一期患侧朝上斜仰截石位输尿管软镜钬激光碎石术治疗效果优于分期截石位输尿管软镜治疗效果,患者结石清除率更高,且一期手术的并发症发生率较低。 展开更多
关键词 一期患侧朝上斜仰截石位 分期截石位 输尿管软镜治疗 肾结石 结石清除率 并发症
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深水水下采油树系统完整性测试技术分析
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作者 肖谭 杨超 +3 位作者 关清涛 赵德 刘军平 伍子登 《石化技术》 CAS 2023年第1期121-123,共3页
针对深水区域的高压环境和复杂的地质条件,水下采油树安装时压力系统的完整性难以判断的问题,建设并形成了自主的水下采油树完整性测试技术。该技术通过自主化水下采油树完整性测试设备方案及测试步骤,提升水下采油树气密测试压力等级至... 针对深水区域的高压环境和复杂的地质条件,水下采油树安装时压力系统的完整性难以判断的问题,建设并形成了自主的水下采油树完整性测试技术。该技术通过自主化水下采油树完整性测试设备方案及测试步骤,提升水下采油树气密测试压力等级至10000psi,扩大移动式气压试验单元压力范围为50~22500psi,实现水下采油树在海底生产过程工况模拟,确保水下采油树保持压力系统完整状态入水安装。技术成果广泛应用于深水气田勘探开发钻完井工程中,有力保障了深水油气田安全高效开发。 展开更多
关键词 水下采油树 完整性测试 压力系统 试压
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深水水下采油树界面系统模拟测试技术分析
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作者 肖谭 蒋东雷 +2 位作者 杨超 范凯 段明付 《石化技术》 CAS 2023年第1期76-78,共3页
针对深水水下采油树处于高压、低温等严苛的海底工作环境且采油树内部流动着高温高压高腐蚀性流体的特性,形成验证井口和采油树匹配性的水下采油树-水下井口界面系统模拟测试技术。该技术通过自主化测试工桩及设计步骤,采用虚拟装配和... 针对深水水下采油树处于高压、低温等严苛的海底工作环境且采油树内部流动着高温高压高腐蚀性流体的特性,形成验证井口和采油树匹配性的水下采油树-水下井口界面系统模拟测试技术。该技术通过自主化测试工桩及设计步骤,采用虚拟装配和集成测试实现水下采油树与水下井口密封性能、连接界面物理匹配、倾斜测试等的检验,保障采油树海上安装时的可靠性。技术成果成功运用于国内多个气田项目采油树SRT接收测试,具有广阔的发展空间和应用前景。 展开更多
关键词 水下采油树 水下井口 测试工桩
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Stair climbing,genetic predisposition,and the risk of incident type 2 diabetes:A large population-based prospective cohort study
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作者 Yuanjue Wu Mengyun Luo +1 位作者 xiao tan Liangkai Chen 《Journal of Sport and Health Science》 SCIE CSCD 2023年第2期158-166,共9页
Background:Cross-sectional evidence and small-scale trials suggest positive effects of stair climbing on cardiometabolic disease and glucose regulation.However,few studies have examined the long-term association betwe... Background:Cross-sectional evidence and small-scale trials suggest positive effects of stair climbing on cardiometabolic disease and glucose regulation.However,few studies have examined the long-term association between stair climbing and the incidence of type 2 diabetes(T2D).We aimed to prospectively evaluate the association of stair climbing with T2D and assess modifications by genetic predisposition to T2D.Methods:We included 451,699 adults(mean age=56.3±8.1 years,mean±SD;55.2%females)without T2D at baseline in the UK Biobank and followed up to March 31,2021.Stair climbing information was collected through the touchscreen questionnaire.Genetic risk score for T2D consisted of 424 single nucleotide polymorphisms.Results:During a median follow up of 12.1 years,14,896 T2D cases were documented.Compared with participants who reported no stair climbing,those who climbed stairs regularly had a lower risk of incident T2D(10-50 steps/day:hazard ratio(HR)=0.95,95%confidence interval(95%CI):0.89-1.00;60-100 steps/day:HR=0.92,95%CI:0.87-0.98;110-150 steps/day:HR=0.86,95%CI:0.80-0.91;>150 steps/day:HR=0.93,95%CI:0.87-0.99,p for trend=0.0007).We observed a significant interaction between stair climbing and genetic risk score on the subsequent T2D risk(p for interaction=0.0004),where the risk of T2D showed a downward trend in subjects with low genetic risk and those who reported stair climbing activity of 110-150 steps/day appeared to have the lowest overall T2D risk among those with intermediate to high genetic risk.Conclusion:A higher number of stairs climbed at home was associated with lower T2D incidence risk,especially among individuals with a low genetic predisposition to T2D.These findings highlight that stair climbing,as incidental physical activity,offers a simple and low-cost complement to public health interventions for T2D prevention. 展开更多
关键词 COHORT Genetic risk score Stair climbing Type 2 diabetes UK Biobank
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海上油气田油套管用材110Cr13S适用性研究
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作者 蒋东雷 余意 +3 位作者 王恒 刁欢 肖谭 王应好 《材料保护》 CAS CSCD 2023年第7期105-109,193,共6页
为评价110Cr13S油套管钢在海上油气田开发工程中的适用性,采用暴露腐蚀试验、原位电化学测试、应力腐蚀测试研究了110Cr13S钢在模拟深水油气田井下高温、高压、CO_(2)与H_(2)S共存腐蚀环境中的腐蚀行为。利用扫描电镜、能谱仪、电化学... 为评价110Cr13S油套管钢在海上油气田开发工程中的适用性,采用暴露腐蚀试验、原位电化学测试、应力腐蚀测试研究了110Cr13S钢在模拟深水油气田井下高温、高压、CO_(2)与H_(2)S共存腐蚀环境中的腐蚀行为。利用扫描电镜、能谱仪、电化学工作站、慢应变速率拉伸试验机测试了110Cr13S油套管钢在温度为129.5℃,H_(2)S分压为358 Pa以及CO_(2)分压为2.754 MPa条件下的腐蚀形貌、腐蚀产物成分、电化学行为及慢应变速率拉伸曲线。结果表明:在模拟深海油气田井况条件下,110Cr13S钢的平均腐蚀速率为0.0044 mm/a,试样表面生成了结构致密完整的钝化膜,具有较好的耐蚀性和优异的抗硫化物应力腐蚀开裂性能,110Cr13S油套管钢适用于深水、高温、高压、CO_(2)与H2S共存条件下的油气井开发油套管选材。 展开更多
关键词 海上油气田 油套管 腐蚀 选材
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保留膀胱手术对膀胱癌复发发生率的影响及其危险因素分析
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作者 肖锬 李警 易熠 《中国卫生标准管理》 2023年第15期105-109,共5页
目的分析保留膀胱手术对膀胱癌复发发生率的影响,并探讨复发的危险因素。方法选取2020年1月—2022年1月龙岩市第一医院泌尿外科收治的接受保留膀胱手术治疗的初发膀胱癌患者200例;患者均接受为期1年时间的随访观察,对其一般资料、术后... 目的分析保留膀胱手术对膀胱癌复发发生率的影响,并探讨复发的危险因素。方法选取2020年1月—2022年1月龙岩市第一医院泌尿外科收治的接受保留膀胱手术治疗的初发膀胱癌患者200例;患者均接受为期1年时间的随访观察,对其一般资料、术后治疗方案、肿瘤学特征及术后复发情况进行观察记录。根据患者1年内的复发情况,将全部患者分为高复发组(1年内复发次数≥2次,HR组)、低复发组(1年内复发1次,LR组)及无复发组(NR组);另根据复发后肿瘤分级有无改变将低级别肿瘤复发患者分为进展组与无进展组。对患者临床特征进行比较。结果200例患者中,110例患者无复发;90例患者复发,复发率为45.0%(90/200),其中LR组、HR组分别为56例、34例。三组的术前吸烟史、肿瘤分期、肿瘤分级、肿瘤数目、术后行规范化膀胱灌注化疗、术后接受干扰素治疗比例比较,差异有统计学意义(P<0.05)。在肿瘤分期、术前吸烟史方面,进展组与无进展组比较,差异有统计学意义(P<0.05)。结论膀胱癌患者采用保留膀胱手术治疗的术后复发风险较高,而术后复发的危险因素包括肿瘤多发、肿瘤分期、肿瘤分级、术前吸烟史、术后未进行膀胱灌注化疗;对于术后复发的膀胱癌患者来讲,术后继续吸烟、初发肿瘤分期较高会导致肿瘤分级增加,术后戒烟能让术后复发风险降低。 展开更多
关键词 保留膀胱手术 膀胱癌 复发 肿瘤学特征 肿瘤分级 危险因素
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输尿管软镜负压鞘在输尿管软镜治疗感染性肾结石患者中的可行性及安全性 被引量:8
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作者 林超禄 肖锬 +2 位作者 余丰 陈钦棋 罗怀景 《中国医学创新》 CAS 2019年第35期5-9,共5页
目的:探讨输尿管软镜负压鞘在输尿管软镜治疗感染性肾结石患者中的可行性及安全性。方法:选取2017年12月-2019年7月本院收治的98例感染性肾结石患者作为研究对象,采用随机数字表法分为观察组(49例)和对照组(49例)。其中对照组采用输尿... 目的:探讨输尿管软镜负压鞘在输尿管软镜治疗感染性肾结石患者中的可行性及安全性。方法:选取2017年12月-2019年7月本院收治的98例感染性肾结石患者作为研究对象,采用随机数字表法分为观察组(49例)和对照组(49例)。其中对照组采用输尿管软镜进行碎石,观察组在对照组基础上采用输尿管软镜负压鞘行输尿管软镜碎石治疗。对比两组手术时间、术中出血量、肾盂内压、住院时间、住院费用、术后结石清除率以及并发症发生率。结果:观察组手术时间、住院时间、术中肾盂内压最小值、肾盂内压最大值和平均肾盂内压均低于对照组(P<0.05);两组术中出血量以及住院费用比较,差异均无统计学意义(P>0.05);经手术治疗后,两组一次性清石率均为100%,但观察组术后1个月的结石清除率明显高于对照组(P<0.05),且观察组术后并发症发生率明显低于对照组(P<0.05)。结论:输尿管软镜负压鞘应用于输尿管软镜治疗感染性肾结石,可缩短手术时间,降低肾盂内压力,提高结石清除率,并降低术后并发症发生率,具有较好的可行性、有效性和安全性。 展开更多
关键词 输尿管软镜 负压鞘 感染性肾结石 可行性 安全性
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工程力学课程思政元素的挖掘与应用探索
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作者 梁翠香 肖潭 于月民 《科教文汇》 2023年第5期120-123,共4页
在专业课程中开展思政教育,是落实立德树人根本任务的重要举措。该文首先探讨了在工程力学课程中开展思政教育的优势;其次,以课程知识点为载体,挖掘课程中蕴含的思政元素,介绍与思政元素对应的教学案例及教学内容,探讨如何将思政元素融... 在专业课程中开展思政教育,是落实立德树人根本任务的重要举措。该文首先探讨了在工程力学课程中开展思政教育的优势;其次,以课程知识点为载体,挖掘课程中蕴含的思政元素,介绍与思政元素对应的教学案例及教学内容,探讨如何将思政元素融入教学活动;最后,研究工程力学课程思政的教学方法和教学模式。 展开更多
关键词 课程思政 工程力学 问题导向式
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IDMs合并心肌损害对GPBB的影响及其意义 被引量:1
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作者 魏继红 姬静璐 +3 位作者 谭笑 王欣 张欢欢 柏金秀 《中国现代医学杂志》 CAS 2018年第20期57-60,共4页
目的研究糖原磷酸化酶同功酶脑型(GPBB)在糖尿病母亲婴儿(IDMs)合并心肌损害时的变化及其意义。方法选取2014年1月-2014年12月于河北大学附属医院入住新生儿病房的132例IDMS为研究对象,于出生后3、6、12和24 h分别检测血清GPBB浓度。比... 目的研究糖原磷酸化酶同功酶脑型(GPBB)在糖尿病母亲婴儿(IDMs)合并心肌损害时的变化及其意义。方法选取2014年1月-2014年12月于河北大学附属医院入住新生儿病房的132例IDMS为研究对象,于出生后3、6、12和24 h分别检测血清GPBB浓度。比较无心肌损害组、心肌损害组及对照组各时间点GPBB的水平变化,分析GPBB与围产高危因素的关系。结果心肌损害组血清GPBB水平高于无心肌损害组和对照组(P<0.05)。母亲孕期血糖控制不良、妊娠期糖尿病病程长(≥3个月)、新生儿低血糖对GPBB水平的影响较大(P<0.05)。结论 GPBB可作为检测IDMs发生心肌损害的早期敏感指标。 展开更多
关键词 糖原磷酸化酶同功酶脑型 糖尿病母亲婴儿 心肌损伤
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蜂窝夹层铝建筑模板的几何优化与试验研究 被引量:5
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作者 肖潭 胡森 +1 位作者 吴伟 熊慧芳 《工程力学》 EI CSCD 北大核心 2019年第2期195-204,共10页
建筑模板技术的创新对混凝土工程具有重要意义。该文对铝建筑模板采用蜂窝夹层结构的可行性进行计算分析与实验研究。首先根据Gibson理论计算蜂窝夹心结构的等效弹性参数,然后参考Reissner模型计算蜂窝夹层模板在均布荷载作用下的应力... 建筑模板技术的创新对混凝土工程具有重要意义。该文对铝建筑模板采用蜂窝夹层结构的可行性进行计算分析与实验研究。首先根据Gibson理论计算蜂窝夹心结构的等效弹性参数,然后参考Reissner模型计算蜂窝夹层模板在均布荷载作用下的应力与变形,再按照铝建筑模板行业标准要求控制模板的变形条件和约束条件,对该模板蜂窝夹层结构的几何参数进行了优化。最后进行蜂窝夹层铝模板的弯曲试验,使用数字摄影测量系统获得了铝模板试件在不同载荷条件下的三维全场变形数据,试验结果与理论计算结果吻合较好。研究结果表明,采用蜂窝夹层结构可将铝建筑模板的质量降低60%以上。 展开更多
关键词 蜂窝夹层结构 建筑模板 几何优化 弯曲试验 变形测量
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消声室内运动声源定位研究
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作者 李元首 陈宝 +3 位作者 张雪 周国成 谭啸 姜涛 《声学与振动》 2015年第3期17-22,共6页
在飞机飞行噪声测量技术中,基于麦克风阵列的运动声源定位技术是飞行噪声测量的核心技术。本文利用对消声室内移测架携带的不同速度的运动声源进行定位分析,利用自研程序处理采集数据获得噪声源实际位置,通过结果对比分析,验证了运动声... 在飞机飞行噪声测量技术中,基于麦克风阵列的运动声源定位技术是飞行噪声测量的核心技术。本文利用对消声室内移测架携带的不同速度的运动声源进行定位分析,利用自研程序处理采集数据获得噪声源实际位置,通过结果对比分析,验证了运动声源定位的可行性,为飞机飞行噪声源定位奠定了基础。 展开更多
关键词 定位 运动声源 阵列
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