Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess l...Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess lipids,which is one of the research hotspots in recent years.Liver disease often develops into chronic disease with high mortality,which seriously affects the life safety and quality of life of patients.Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress,plays an important role in a variety of liver diseases,has the characteristics of two-way regulation,and moderate autophagy has a protective effect.Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease.at present,regulating autophagy is considered as a potential treatment.Based on chronic viral hepatitis,liver fibrosis,non-alcoholic fatty liver disease,acute liver failure and primary liver cancer,this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases.to explore new therapeutic targets for liver diseases,in order to provide new ideas and basis for clinical diagnosis and treatment.展开更多
The incidence of liver fibrosis is increasing worldwide,and if left untreated,it will later develop into cirrhosis with a high mortality rate.In this paper,the activation pathway and related mechanism of stellate cell...The incidence of liver fibrosis is increasing worldwide,and if left untreated,it will later develop into cirrhosis with a high mortality rate.In this paper,the activation pathway and related mechanism of stellate cells in liver fibrosis are introduced,and some current therapeutic methods are summarized.These results suggest that stellate cells play an important role in liver fibrosis,and targeted therapy for the purpose of inhibiting the activation of stellate cells and inducing their apoptosis is expected to be an effective regimen to reverse liver fibrosis.However,there are some problems such as insufficient in-depth study of related mechanisms and imperfect experiments.In future animal experiments and clinical trials,more studies can be carried out to provide high-quality protocols for the treatment of liver fibrosis.展开更多
基金General Program of National Natural Science Foundation of China(No.81774236)National Natural Science Foundation of China(No.81960841)+1 种基金Guangxi Science and Technology Planning Project(No.GuikeAD17129001)Project supported by Guangxi Natural Science Foundation(No.2018GXNSFAA281096)。
文摘Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess lipids,which is one of the research hotspots in recent years.Liver disease often develops into chronic disease with high mortality,which seriously affects the life safety and quality of life of patients.Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress,plays an important role in a variety of liver diseases,has the characteristics of two-way regulation,and moderate autophagy has a protective effect.Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease.at present,regulating autophagy is considered as a potential treatment.Based on chronic viral hepatitis,liver fibrosis,non-alcoholic fatty liver disease,acute liver failure and primary liver cancer,this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases.to explore new therapeutic targets for liver diseases,in order to provide new ideas and basis for clinical diagnosis and treatment.
基金Fund Project:General Program of National Natural Science Foundation of China(No.81774236)General Program of National Natural Science Foundation of China(No.81960841)。
文摘The incidence of liver fibrosis is increasing worldwide,and if left untreated,it will later develop into cirrhosis with a high mortality rate.In this paper,the activation pathway and related mechanism of stellate cells in liver fibrosis are introduced,and some current therapeutic methods are summarized.These results suggest that stellate cells play an important role in liver fibrosis,and targeted therapy for the purpose of inhibiting the activation of stellate cells and inducing their apoptosis is expected to be an effective regimen to reverse liver fibrosis.However,there are some problems such as insufficient in-depth study of related mechanisms and imperfect experiments.In future animal experiments and clinical trials,more studies can be carried out to provide high-quality protocols for the treatment of liver fibrosis.
