Opioid addiction is one of the top challenges for society, particularly in China. To fight it, the key is to reveal its underlying mechanisms. Among the strategies to overcome the mental damage caused by opioids, inve...Opioid addiction is one of the top challenges for society, particularly in China. To fight it, the key is to reveal its underlying mechanisms. Among the strategies to overcome the mental damage caused by opioids, investigating native anti-opioid peptides derived from mammalian （including human） brains is an important option because of safety concerns. In 1983, diazepam-binding inhibitor （DBI）, a 10-kDa peptide, was first derived from rat brains （Guidotti et al., 1983）. After repeated treatment with morphine, the DBI level is enhanced in rodent brains （Katsura et al., 1998; Shibasaki et al., 2006）.展开更多
基金ACKNOWLEDGEMENTS We thank Dr. lain C Bruce for helpful comments on the manuscript. 77 and ZL were partially supported by grants from the National Basic Research Program （973 Program） （No. 2012CB518006）, and the National Natural Science Foundation of China （Grant Nos. 31228010, 31171026, 31100597, 31327901, 31221002, 31330024, 31400708, 31670843, 31521062, and SQ2011SF11B01041）. Yu-Zhen Chen, Xiao-Cun Li, Zhen-Quan Guo, Li Zhou, Zhuan Zhou, Song-vve no conflict of interest. This article does not contain any studies with human subjects performed by the any of the authors. All institutional and national guidelines for the care and use of laboratory animals were followed.
文摘Opioid addiction is one of the top challenges for society, particularly in China. To fight it, the key is to reveal its underlying mechanisms. Among the strategies to overcome the mental damage caused by opioids, investigating native anti-opioid peptides derived from mammalian （including human） brains is an important option because of safety concerns. In 1983, diazepam-binding inhibitor （DBI）, a 10-kDa peptide, was first derived from rat brains （Guidotti et al., 1983）. After repeated treatment with morphine, the DBI level is enhanced in rodent brains （Katsura et al., 1998; Shibasaki et al., 2006）.
