Objective:To analyze the changes of EEG,neurological function,immune function and inflammatory factors in children with viral encephalitis and their clinical significance.Methods:60 children with viral encephalitis in...Objective:To analyze the changes of EEG,neurological function,immune function and inflammatory factors in children with viral encephalitis and their clinical significance.Methods:60 children with viral encephalitis in our hospital were collected as observation group and 60 healthy children were collected as control group during the same period.The electroencephalogram(EEG)of the children in the observation group was observed,and the serum levels of S100B protein(S100B),neuron specific enolase(NSE),myelin basic protein(MBP),immunoglobulin G(IgG),immunoglobulin M(IgM),hypersensitive C-reactive protein(hs-CRP)and cystatin C(Cyst C)were detected and compared between the two groups.Results:The electroencephalogram results of the observation group showed that 55 cases were abnormal,the positive rate was 91.67%.Among them,30 cases were mild abnormal,19 cases were moderate abnormal and 6 cases were severe abnormal.The serum levels of S100B,NSE and MBP of patients in the observation group were(231.26±25.74)ng/L,(18.92±2.03)ug/L,(1.44±16.23)ug/L,which were significantly higher than the control group(P<0.05);The serum levels of IgG and IgM were(7.45±0.76)g/L,(0.83±0.09)g/L respectively,which were significantly lower than those in the control group(P<0.05).The serum levels of hs-CRP and Cyst C of patients in the observation group were(4.59±0.51)mg/L,(14.38±0.09)mg/L,respectively,which were higher than those of the control group(P<0.05).Conclusion:The positive rate of EEG diagnosis was high.The changes of neurological function,immune function factors,hs-CRP and Cyst C levels may become important reference indicators for auxiliary diagnosis and early treatment of children with viral encephalitis.Neurological function,immune function factors,hs-CRP and Cyst C are all related to the progression of viral encephalitis.The above indicators can be used as important indicators for assistant diagnosis and early treatment of viral encephalitis in children.展开更多
基金financially supported by the National Key Research and Development Project of China (Nos. 2021YFC2902802, 2021YFC2902805, 2021YFC2902602, 2021YFC2902604)the Natural Science Foundation of Guangdong Province,China (No. 2023A1515030145)Guangdong Academy of Science Special Funds,China (Nos. 2020GDASYL-0104027, 2022GDASZH-2022010104, 2021GDASYL-20210302004)。
基金Youth Science Foundation of National Natural Science Foundation of China.Project No:81701548.
文摘Objective:To analyze the changes of EEG,neurological function,immune function and inflammatory factors in children with viral encephalitis and their clinical significance.Methods:60 children with viral encephalitis in our hospital were collected as observation group and 60 healthy children were collected as control group during the same period.The electroencephalogram(EEG)of the children in the observation group was observed,and the serum levels of S100B protein(S100B),neuron specific enolase(NSE),myelin basic protein(MBP),immunoglobulin G(IgG),immunoglobulin M(IgM),hypersensitive C-reactive protein(hs-CRP)and cystatin C(Cyst C)were detected and compared between the two groups.Results:The electroencephalogram results of the observation group showed that 55 cases were abnormal,the positive rate was 91.67%.Among them,30 cases were mild abnormal,19 cases were moderate abnormal and 6 cases were severe abnormal.The serum levels of S100B,NSE and MBP of patients in the observation group were(231.26±25.74)ng/L,(18.92±2.03)ug/L,(1.44±16.23)ug/L,which were significantly higher than the control group(P<0.05);The serum levels of IgG and IgM were(7.45±0.76)g/L,(0.83±0.09)g/L respectively,which were significantly lower than those in the control group(P<0.05).The serum levels of hs-CRP and Cyst C of patients in the observation group were(4.59±0.51)mg/L,(14.38±0.09)mg/L,respectively,which were higher than those of the control group(P<0.05).Conclusion:The positive rate of EEG diagnosis was high.The changes of neurological function,immune function factors,hs-CRP and Cyst C levels may become important reference indicators for auxiliary diagnosis and early treatment of children with viral encephalitis.Neurological function,immune function factors,hs-CRP and Cyst C are all related to the progression of viral encephalitis.The above indicators can be used as important indicators for assistant diagnosis and early treatment of viral encephalitis in children.
