Precise and dynamic regulation of gene expression is a key feature of immunity.In recent years,rapid advances in transcriptome profiling analysis have led to recognize long noncoding RNAs(lncRNAs)as an additional laye...Precise and dynamic regulation of gene expression is a key feature of immunity.In recent years,rapid advances in transcriptome profiling analysis have led to recognize long noncoding RNAs(lncRNAs)as an additional layer of gene regulation context.In the immune system,lncRNAs are found to be widely expressed in immune cells including monocytes,macrophages,dendritic cells(DC),neutrophils,T cells and B cells during their development,differentiation and activation.However,the functional importance of immune-related lncRNAs is just emerging to be characterized.In this review,we discuss the up-to-date knowledge of lncRNAs in immune regulation.展开更多
基金This work was supported in part by the grants including R01DK064240(to XDT)and R21AA020494(to XDT)National Institutes of Health and Merit Review Award(I01BX001690 to XDT)from US Department of Veterans Affairs.
文摘Precise and dynamic regulation of gene expression is a key feature of immunity.In recent years,rapid advances in transcriptome profiling analysis have led to recognize long noncoding RNAs(lncRNAs)as an additional layer of gene regulation context.In the immune system,lncRNAs are found to be widely expressed in immune cells including monocytes,macrophages,dendritic cells(DC),neutrophils,T cells and B cells during their development,differentiation and activation.However,the functional importance of immune-related lncRNAs is just emerging to be characterized.In this review,we discuss the up-to-date knowledge of lncRNAs in immune regulation.
