Structure,electronic,and nonlinear optical properties of superalkaline M_(3)O(M=Li,Na)doped cyclo[18]carbon

Cyclo[18]carbon has received considerable attention thanks to its novel geometric configuration and special electronic structure.Superalkalis have low ionization energy.Doping a superalkali in cyclo[18]carbon is an effective method to improve the optical properties of the system because considerable electron transfer occurs.In this paper,the geometry,bonding properties,electronic structure,absorption spectrum,and nonlinear optical(NLO)properties of superalkaline M_(3)O(M=Li,Na)-doped cyclo[18]carbon were studied by using density functional theory.M_(3)O and the C_(18) rings are not coplanar.The C_(18) ring still exhibits alternating long and short bonds.The charge transfer between M_(3)O and C_(18) forms stable[M_(3)O]+[C_(18)]-ionic complexes.C_(18)M_(3)O(M=Li,Na)shows striking optical nonlinearity,i.e.,their first-and second-order hyperpolarizability(βvec andγ||)increase considerably atλ=1907 nm and 1460 nm.

脉冲射频联合富血小板血浆治疗老年带状疱疹的临床研究

目的观察超声引导下胸椎旁脉冲射频联合富血小板血浆(PRP)注射治疗老年胸段急性期带状疱疹性神经痛的临床疗效。方法选取2019年1月—2020年6月在秦皇岛市第一医院住院治疗的80例老年胸段急性期带状疱疹性神经痛患者,随机分为实验组和对照组,每组40例。两组均接受相同的基础药物和超声引导下胸椎旁脉冲射频治疗,实验组、对照组分别联合PRP注射、神经阻滞治疗。记录两组治疗前后疼痛数字评分法(NRS)和匹兹堡睡眠质量指数(PSQI)评分;出院后普瑞巴林服用情况、皮损愈合时间及带状疱疹后神经痛(PHN)发生率。结果实验组与对照组治疗前和治疗后1周、1个月、2个月、3个月的NRS评分和PSQI评分在不同时间、不同组间及变化趋势上比较,差异有统计学意义(P <0.05)。实验组普瑞巴林使用量和使用时间、皮损愈合时间及PHN发生率均低于对照组(P <0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论超声引导下胸椎旁脉冲射频联合PRP注射能有效缓解老年急性期带状疱疹性神经痛,同时可以促进带状疱疹皮损愈合,降低PHN发生率。

Numerical simulation of wind-driven circulation and pollutant transport in Taihu Lake based on a quadtree grid

In this study,a two-dimensional flow-pollutant coupled model was developed based on a quadtree grid.This model was established to allow the accurate simulation of wind-driven flow in a large-scale shallow lake with irregular natural boundaries when focusing on important smallscale localized flow features.The quadtree grid was created by domain decomposition.The governing equations were solved using the finite volume method,and the normal fluxes of mass,momentum,and pollutants across the interface between cells were computed by means of a Godunov-type Osher scheme.The model was employed to simulate wind-driven flow in a circular basin with non-uniform depth.The computed values were in agreement with analytical data.The results indicate that the quadtree grid has fine local resolution and high efficiency,and is convenient for local refinement.It is clear that the quadtree grid model is effective when applied to complex flow domains.Finally,the model was used to calculate the flow field and concentration field of Taihu Lake,demonstrating its ability to predict the flow and concentration fields in an actual water area with complex geometry.

Cavitation erosion behavior of WC coatings on CrNiMo stainless steel by laser alloying

The WC powder was precoated on the surface of CrNiMo stainless steel and then made into an alloying layer by using the laser alloying technique. Phases in the layers were investigated by X-ray diffraction （XRD） analysis and surface morphologies after cavitation erosion were observed with the help of scanning electron microscopy （SEM）. The cavitation erosion behavior of the CrNiMo stainless steel and WC laser alloying layer in distilled water was tested with the help of ultrasonic vibration cavitation erosion equipment. The results showed that the thickness of the laser alloying layer was about 0.13 mm. The layer had a dense microstructure, metallurgically bonded to the substrate, and no crack had been found. The cavitation erosion mass loss rate of the laser alloying layer was only 2/5 that of the CrNiMo stainless steel. The layer had better cavitation resistance properties because of its metallurgical combination and the strengthening effects of the precipitate phases.

Short- and long-term outcomes associated with enhanced recovery after surgery protocol vs conventional management in patients undergoing laparoscopic gastrectomy

BACKGROUND At present,the enhanced recovery after surgery(ERAS)protocol is widely implemented in the field of gastric surgery.However,the effect of the ERAS protocol on the long-term prognosis of gastric cancer has not been reported.AIM To compare the effects of ERAS and conventional protocols on short-term outcomes and long-term prognosis after laparoscopic gastrectomy.METHODS We retrospectively analyzed the data of 1026 consecutive patients who underwent laparoscopic gastrectomy between 2012 and 2015.The patients were divided into either an ERAS group or a conventional group.The groups were matched in a 1:1 ratio using propensity scores based on covariates that affect cancer survival.The primary outcomes were the 5-year overall and cancer-specific survival rates.The secondary outcomes were the postoperative short-term outcomes and inflammatory indexes.RESULTS The patient demographics and baseline characteristics were similar between the two groups after matching.Compared to the conventional group,the ERAS group had a significantly shorter postoperative hospital day(7.09 d vs 8.67 d,P<0.001),shorter time to first flatus,liquid intake,and ambulation(2.50 d vs 3.40 d,P<0.001;1.02 d vs 3.64 d,P<0.001;1.47 d vs 2.99 d,P<0.001,respectively),and lower medical costs($7621.75 vs$7814.16,P=0.009).There was a significantly higher rate of postoperative complications among patients in the conventional group than among those in the ERAS group(18.1 vs 12.3,P=0.030).Regarding inflammatory indexes,the C-reactive protein and procalcitonin levels on postoperative day 3/4 were significantly different between the two groups(P<0.001 and P=0.025,respectively).The ERAS protocol was associated with significantly improved 5-year overall survival and cancer-specific survival rates compared with conventional protocol(P=0.013 and 0.032,respectively).When stratified by tumour stage,only the survival of patients with stage III disease was significantly different between the two groups(P=0.044).CONCLUSION Adherence to the ERAS protocol improves both the short-term outcomes and the 5-year overall survival and cancer-specific survival of patients after laparoscopic gastrectomy.

Extract of Cycas revoluta Thunb. enhances the inhibitory effect of 5-fluorouracil on gastric cancer cells through the AKT-mTOR pathway

BACKGROUND Gastric cancer is one of the most common and deadly malignancies worldwide.Despite recent medical progress, the 5-year survival rate of gastric cancer is still unsatisfactory. 5-fluorouracil(5-Fu) is one of the first-line antineoplastic treatments for gastric cancer, as it can effectively induce cancer cell apoptosis.However, the effect of 5-Fu is limited due to drug resistance of the malignant tumor. Previous studies have reported that Sotetsuflavone from Cycas revoluta Thunb. can markedly suppress lung cancer cell proliferation by apoptosis,though its effect on gastric cancer remains unknown.AIM To investigate the inhibitory effect of Cycas revoluta Thunb. and to determine whether it can overcome gastric cancer cell drug resistance to 5-Fu.METHODS Cell viability was examined to determine whether the natural extract of Cycas revoluta Thunb. induced gastric cancer cell death. The half-maximal effective concentration and the half-maximal lethal concentration were calculatede.Wound-healing and transwell assays were performed to examine gastric cancer cell motility. Clonogenic assays were performed to investigate the synergistic effects of Cycas revoluta Thunb. with 5-Fu, and apoptotic bodies were detected by Hoechst staining. Western blotting was performed to examine the expression of related proteins and to investigate the molecular mechanism of Cycas revoluta Thunb.-induced cancer cell apoptosis. The expressions of proteins, including mammalian target of rapamycin(mTOR) and p-AKT, were detected in different combinations of treatments for 48 h, then analyzed by ECL detection.RESULTS Gastric cancer cells were more sensitive to the natural extract of Cycas revoluta Thunb. compared to normal gastric epithelial cells, and the extract effectively inhibited gastric cancer cell migration and invasion. The extract improved the anti-cancer effect of 5-Fu by enhancing the chemosensitization of gastric cancer cells. Extract plus 5-Fu further reduced the expression of the drug-resistancerelated proteins p-AKT and mTOR after 48 h compared to 5-Fu alone. Compared to 5-Fu treatment alone, mTOR and p-AKT expression was significantly reduced by about 50% and 75%, respectively. We also found that the natural extract of Cycas revoluta Thunb. further increased 5-Fu-induced gastric cancer cell apoptosis. Expression of apoptosis-related protein X-linked inhibitor of apoptosis protein and apoptosis inducing factor were significantly reduced and increased,respectively, in the 5-Fu-resistant gastric cancer line SGC-7901/R treated with extract plus 5-Fu, while the expression of survivin did not change.CONCLUSION The natural extract of Cycas revoluta Thunb. effectively inhibited gastric cancer cell growth and enhanced the anti-cancer effect of 5-Fu through the AKT-mTOR pathway.

Influence of deformation path on the forming effect in a multistep flexible rolling process

The flexible rolling process(FRP) is a novel three-dimensional(3 D) forming process that combines the multipoint and traditional rolling forming. The principle of FRP is based on thickness thinning, so the deformation path significantly impacts the forming effect. In this study, the multistep forming process with different deformation paths was introduced to improve the forming effect of FRP. For instance, with the convex surface part, three finite element models of multistep FRP(MSFRP) were established. The corresponding numerical simulations and forming experiments performed among different deformation paths showed the surface part with a longer effective forming region was obtained and the forming regions with more steps in MSFRP were smoother. Thus, the sheet-metal utilization rate was greatly improved. Moreover, the MSFRP can improve the longitudinal bending effect dramatically and thereby endowing the forming part with a better forming effect. Therefore, MSFRP is a prospective method for broad applications.

Eltrombopag-related renal vein thromboembolism in a patient with immune thrombocytopenia: A case report

BACKGROUND Eltrombopag is an orally administered thrombopoietin receptor agonist linked to a heightened risk of treatment-related thromboembolism.Both venous and arterial thromboses have been documented in the medical literature.CASE SUMMARY In the absence of nephropathy,a 48-year-old patient receiving eltrombopag for immune thrombocytopenia(ITP)developed renal vein thrombosis and pulmonary embolism.The renal vein thrombus spontaneously resolved during subsequent anticoagulant treatment,restoring venous circulation.CONCLUSION A rapid upsurge in platelets,rather than their absolute number,may trigger thrombotic events in this setting.For patients at high thrombotic risk,individualized eltrombopag dosing and vigilance in platelet monitoring are perhaps needed during treatment of ITP.

Expression, purification and bioactivity of human augmenter of liver regeneration

瞄准：为肝新生(hALR ) 的原核生物、真核细胞的人的 augmenter 构造表示向量并且学习他们的生物活动。方法：hALRcDNA 克隆从原生质标志 pGEM-T-hALR 被获得，并且 cDNA 是克隆进 prokatyotic 表示向量 pGEX-4T-2 的潜水艇。recombinant 向量和 pGEX-4T-2hALR 被酶消化并且 DNA 定序识别并且转变了成 E 关口 i JM109。断然选择的克隆被 GST-hALR 熔化蛋白质的表示与 IPTG 导致，然后，熔化蛋白质被 glutathine s-transferase (GST ) 净化 sepharose 4B 亲密关系层析，由测量 H 胸腺嘧啶核甙加入由凝血酵素劈开， hALR 单体被获得并且检测。结果：从原生质标志 pGEM-T-hALR 的 PCR 的产品被 1.5% sepharose 电气泳动检验。特定的带与理论的是重合的。顺序是精确的，酶消化的 pGEX-4T-hALP 与理论的是重合的。顺序是精确的，碎片在积极方向被插入。recombinant 向量被转变成 E 关口 i JM109。SDS 页证明导致的富有表达力的熔化蛋白质与 41 kDa 的分子量给一个单身的乐队看了。产品被净化并且劈开。GST 和 hALR 的分子量是 26 kDa， 15 kDa 分别地。recombinant 熔化蛋白质说明了细菌的溶解产物的 31% 全部的可溶的蛋白质。在主要文化和 HepG2 房间线加到成年老鼠 hepatocytes 的培养基的 HALR 能显著地与相关控制组相比提高 DNA 合成的率(P 【 0.01 ) 。结论：净化的 hALR 有能力刺激 DNA 在主要文化和 HepG2 房间在试管内的成年老鼠 hepatocytes 的合成，和罐头为它的临床的申请提供证据。

Urethral pressure profilometry in artificial urinary sphincter implantation: A case report

BACKGROUND Artificial urethral sphincter(AUS)implantation is currently the gold standard for treating moderate and severe urinary incontinence.Currently,cuffs are chosen based on the surgeon’s experience,and adjusting cuff tightness is crucial.The TDOC air-charged catheter has not been proven to be inferior to traditional catheters.We report how intraoperative urethral pressure profilometry is performed using a T-DOC air-charged catheter with ambulatory urodynamic equipment,to guide cuff selection and adjustment.CASE SUMMARY A 67-year-old man presented to our hospital with complete urinary incontinence following transurethral prostatectomy,using five pads/d to maintain local dryness.Preoperatively,the maximum urethral pressure(MUP)and maximum urethral closure pressure(MUCP)were 52 cmH2O and 17 cmH2O,respectively.An AUS was implanted.Intraoperatively,in the inactivated state,the MUP and MUCP were 53 cmH2O and 50 cmH2O,respectively;in the activated state,they were 112 cmH2O and 109 cmH2O,respectively.The pump was activated 6 wk postoperatively.Re-measurement of the urethral pressure on the same day showed that in the inactivated state,MUP and MUCP were 89 cmH2O and 51 cmH2O,respectively,and in the activated state,120 cmH2O and 92 cmH2O,respectively.One month after device activation,telephonic follow-up revealed that pad use had decreased from five pads/d to one pad/d,which met the standard for social continence(0-1 pad per day).There were no complications.CONCLUSION The relationship between intraoperative urethral pressure and urinary continence post-surgery can provide data for standardizing AUS implantation and evaluating efficacy.

Flow patterns and critical criteria of thermally stratified shear flow in braided rivers

Flow characteristics of thermally stratified shear flow in braided rivers are particularly complicated and poorly understood. In this study, a series of typical flow patterns was examined and their critical criteria were determined. Four flow patterns were identified: mixed, locally unstable, continuously stratified, and two-layer flow. Temperature distributions of the four types of flow patterns were analyzed and compared.The critical Froude numbers for unstable flow, FDcr1, and stable flow, FDcr2, were determined to be 6 and 1, respectively, and comparison of FDcr1 and FDcr2 to the peak Froude numbers, FD1 at the outer bank and FD2 at the inner bank along the anabranch, allowed the flow patterns to be assessed. Then, a discriminant based on initial Jeffreys-Keulegan stability parameters was established to distinguish the flow stages from twolayer flow to completely mixed flow. It is indicated that the three critical Jeffreys-Keulegan parameters increased with the diversion angle of braided rivers. Results also show that, compared to the stratified flow in straight and curved channels, it was more difficult for braided stratified flow to maintain as two-layer flow, and it more easily became mixed flow. Consequently, empirical expressions for stability criteria of the thermally stratified shear flow in braided rivers are presented.

On quantitative structure-activity relationships between hydrazine derivatives and β irradiation

In this study, solutions of hydrazine and its derivatives were irradiated using a pulsed electron beam to determine the half-reaction time of radiolysis. 3 D structures of the hydrazine derivatives were optimized, and their energies were calculated using density functional theory with the B3 LYP method and 6-311 +(3 d, 3 p) basis set.For the first time, the 3 D quantitative structure-activity relationship(QSAR) equation describing the relationship between the hydrazine derivative structures and rate of radiolysis has been established using SPSS software.Pearson correlation analysis revealed a close correlation between the total energies of the molecules and half-reaction times. In the QSAR equation, Y =-7583.464 +54.687 X_1+94333.586 X_2,Y,X_1,and X_2 are the half-reaction time, total energy of the molecule, and orbital transition energy, respectively. The significance levels of the regression coefficients were 0.006 and 0.031, i.e., both less than 0.05. Thus, this model fully explains the relationship between hydrazine derivatives and β radiolysis stability.The results show that the total energy of the molecule and orbital transition energy are the main factors that influence the β radiolysis stability of these hydrazine derivatives.

Laboratory simulation of soil respiration response to environmental conditions in intertidal zones of Jiangsu Province,China

As major contributor to the blue carbon sink,intertidal zones play a crucial role in the global carbon cycle.In recent years,more attention has been given to the carbon cycle in intertidal wetlands.However,due to highly variable and uncertain environmental conditions,it is difficult to clarify the quantitative relationship between soil respiration and environmental factors through in-situ experiments.In this study,the response of soil respiration characteristics to variations in the temperature and water table was investigated using a monitoring apparatus of CO_(2)flux at the soil-air interface in the intertidal zone.The results showed that soil respiration flux was significantly correlated with temperature,and the correlation best fitted the DoseResp function.Meanwhile,the respiration flux was enhanced with the descent of water table,a relationship could be described by a quadratic function.The effect of the water table on soil respiration became more pronounced with the rise of temperature.These results provide significant clarification of the impact of human activities on the carbon cycle in bare intertidal zones and as well as support for numerical simulations of the carbon cycle in bare intertidal zones.

Motion planning for redundant prismatic-jointed manipulators in the free-floating mode

This paper investigates the motion planning of redundant free-floating manipulators with seven prismatic joints. On the earth, prismatic-jointed manipulators could only position their end-effectors in a desired way. However, in space, the end-effectors of free-floating manipulators can achieve both the desired orientation and desired position due to the dynamical coupling between manipulator and satellite movement, which is formally expressed by linear and angular momentum conservation laws. In this study, a tractable algorithm particle swarm optimization combined with differential evolution （PSODE） is provided to deal with the motion planning of redundant free-floating prismatic-jointed manipulators, which could avoid the pseudo inverse of the Jacobian matrix. The polynomial functions, as argument in sine functions are used to specify the joint paths. The co- efficients of the polynomials are optimized to achieve the desired end-effector orientation and position, and simulta- neously minimize the unit-mass-kinetic energy using the redundancy. Relevant simulations prove that this method pro- vides satisfactory smooth paths for redundant free-floating prismatic-jointed manipulators. This study could help to recognize the advantages of redundant prismatic-jointed space manipulators.

Investigation on the stall types in impellers with different blade numbers

Stall is a complex flow phenomenon and its existence usually shows significant differences in different impeller forms.In this paper,the flow field characteristics and mechanism of stall types in impellers with different blade numbers were studied through the combination of experiment and numerical simulation at stall inception stage.In the experiments,it was observed that the five-blade impeller entered the rotating stall stage from a relatively stable flow field within a small flow rate interval.For the six-blade impeller,the root cause that stall vortices appeared in channels alternately rather than each one evenly was also reasonably explained.The validated numerical simulation method was utilized to reveal the three-dimensional flow field in impeller channels.The results indicate the swirling vortex near the impeller shroud was periodically sucked in and escaped from region near the blade suction side,which was the fundamental driving force of rotating stall.The sudden change of flow field caused by the fusion of the separation vortex at the channel inlet and the vortex induced by the swirling vortex near shroud is the essential reason for the formation of alternating stall.What’s more,the stall inception flow field is clearly defined in impellers,which is of great significance for the further analysis of stall characteristics.Based on the distribution characteristics of vortex structure near impeller shroud with different blade numbers at different flow rate conditions,this paper deeply investigated the formation mechanism of different stall types in impellers.

Two Faces of One Seed： Hormonal Regulation of Dormancy and Germination

Seed plants have evolved to maintain the dormancy of freshly matured seeds until the appropriate time for germination. Seed dormancy and germination are distinct physiological processes, and the transition from dormancy to germination is not only a critical developmental step in the life cycle of plants but is also impor- tant for agricultural production. These processes are precisely regulated by diverse endogenous hormones and environmental cues. Although ABA （abscisic acid） and GAs （gibberellins） are known to be the primary phytohormones that antagonistically regulate seed dormancy, recent findings demonstrate that another phytohormone, auxin, is also critical for inducing and maintaining seed dormancy, and therefore might act as a key protector of seed dormancy. In this review, we summarize our current understanding of the sophisticated molecular networks involving the critical roles of phytohormones in regulating seed dormancy and germination, in which AP2-domain-containing transcription factors play key roles. We also discuss the interactions （crosstalk） of diverse hormonal signals in seed dormancy and germination, focusing on the ABA/GA balance that constitutes the central node.

Diagnosis and treatment of herpangina:Chinese expert consensus

Background Herpangina is a common infectious disease in childhood caused by an enterovirus.This consensus is aiming to standardize and improve herpangina prevention and clinical diagnosis.Methods The Subspecialty Group of Infectious Diseases,the Society of Pediatric,Chinese Medical Association and Nation Medical Quality Control Center for Infectious Diseases gathered 20 experts to develop the consensus,who are specialized in diagnosis and treatment of herpangina.Results The main pathogenic serotypes of herpangina include Coxsackievirus-A,Enterovirus-A and Echovirus.Its diagnosis can be rendered on the basis of history of epidemiology,typical symptoms,characteristic pharyngeal damage and virological tests.The treatment is mainly symptomatic,and incorporates topical oral spray with antiviral drugs.The course of herpangina generally lasts 4-6 days with a good prognosis.Conclusion The consensus could provide advices and references for the diagnosis,treatment and management of herpangina in children.

Microstructure and mechanical properties of NbZrTi and NbHfZrTi alloys

Two medium-entropy alloys,NbZrTi and NbHfZrTi,were prepared by arc melting.Both NbZrTi and NbHfZrTi alloys are composed of simple body-centered cubic(bcc)solid solution phase and exhibit dendritic structure.After being homogenized,both NbZrTi and NbHfZrTi alloys are still composed of the single bcc solid solution phase,but the microstructure of the two alloys transforms from the dendritic structure into the polycrystalline structure.Two alloys display significantly workhardening effect during compression at room temperature and show relatively good deformation plasticity during compressive deformation at room temperature.For NbZrTi and NbHfZrTi alloys,the dynamic recrystallized grains form along the boundary during compression at the temperatures of 1073 and 1273 K.

Analysis of semen quality of 38 905 infertile male patients during 2008- 2016 in Wenzhou, China

This study analyzed the trend in semen quality of infertile male patients in Wenzhou,China,based on the data obtained from 38905 patients during 2008-2016 in The First Affiliated Hospital of Wenzhou Medical University(Wenzhou,China).The results showed that only 24.9%of the patients had normal semen quality.For the semen quality of infertile male patients,that of the workers and 40-year-olds was significantly worse than the other occupational and age groups.For all the infertile patients,low semen volume,asthenozoospermia,and teratozoospermia accounted for 8.4%,50.5%,and 54.1%,respectively.During 2008-2016,the annual mean percentage of fast forward motile spermatozoa,percentage of total forward motile spermatozoa,and percentage of spermatozoa with normal morphology decreased linearly with slopes of-2.11,-2.59,and-0.70,respectively.The proportion of patients with asthenozoospermia and multi-abnormal spermatozoa increased during 2008-2016 with slopes of 4.70 and 4.87,respectively,while for low semen volume,it decreased with a slope of-0.47 in the same time period.The proportion of patients with teratozoospermia increased from 2008 to 2011 and from 2011 to 2016 with slopes of 17.10 and 2.09,respectively.In general,the deteriorating trend of semen quality of infertile male patients in Wenzhou was obvious.Future efforts should be made to reveal the adverse influences on semen quality,such as occupational exposure,environmental quality,and living habits.Furthermore,more pervasive reproduction health education is necessary.