Manifestation of the malignant progression of glioma following initial intracerebral hemorrhage:A case report

BACKGROUND Intracranial hemorrhage is extremely rare during the initial stages of glioma.Here,we report a case of glioma with unclassified pathology and intracranial bleeding.CASE SUMMARY After the second surgery for intracerebral hemorrhage,the patient experienced weakness in the left arm and leg,but could walk unassisted.One month after discharge,the weakness in the left limbs had exacerbated and the patient also suffered from headaches and dizziness.A third surgery was ineffective against the rapidly growing tumor.Intracerebral hemorrhage may be the initial symptom of glioma in some rare cases,and atypical perihematomal edema can be used for diagnosis during an emergency.Certain histological and molecular features seen in our case were similar to that of glioblastoma with a primitive neuronal component,which is termed diffuse glioneuronal tumor with features similar to oligodendroglioma and nuclear clusters(DGONC).The patient underwent three surgeries to remove the tumor.The first tumor resection had been performed when the patient was 14-years-old.Resection of the hemorrhage and bone disc decompression were performed when the patient was 39-years-old.One month after the last discharge,the patient underwent neuronavigation-assisted resection of the right frontotemporal parietal lesion plus extended flap decompression.On the 50^(th)d after the third operation,computed tomography imaging showed rapid tumor growth accompanied by brain hernia.The patient was discharged and died 3 d later.CONCLUSION Glioma can present as bleeding in the initial stage and should be considered in such a setting.We have reported a case of DGONC,which is a rare molecular subtype of glioma with a unique methylation profile.

右美托咪定对肿瘤作用的研究进展

手术是目前治疗多数实体肿瘤的首选方法,围手术期麻醉药的使用对肿瘤发展及预后产生极大的影响。右美托咪定是目前临床常用的麻醉药物之一,广泛应用于全身麻醉和区域阻滞。研究发现,右美托咪定在体内外可促进乳腺癌、肺癌和胃肠道肿瘤的进展,也有数据提示右美托咪定可抑制卵巢癌、骨肉瘤的生长。探究右美托咪定对肿瘤的作用可以指导临床用药,规避临床风险。该文对右美托咪定对肿瘤的影响及机制作一综述。

Effect of the Jintiange capsule-assisted internal fixation on fracture healing and bone metabolism activity of patients with Colles fracture

Objective:To study the effect of the Jintiange capsule-assisted internal fixation on fracture healing and bone metabolism activity of patients with Colles fracture.Methods:A total of 120 patients with Colles fracture who received internal fixation in the hospital between July 2014 and May 2016 were collected and divided into control group and observation group according to the random number table method, 60 cases in each group. The control group received regular open reduction and internal fixation, and the observation group received Jintiange capsule-assisted internal fixation. The fracture healing quality as well as calcium phosphorus metabolism index and bone metabolism index levels were compared between the two groups before and after the operation.Results: Before operation, the differences in fracture end parameter levels, peripheral blood calcium and phosphorus metabolism index contents and serum bone metabolism index contents were not statistically significant between the two groups of patients;differences in fracture end radial incline, ulnar inclination and processus styloideus radii height were not statistically significant between the two groups of patients 6 weeks after surgery;peripheral blood Ca, P and ALP contents of observation group 6 weeks after surgery were significantly higher than those of control group, and serum bone formation indexes BGP and OPG contents were higher than those of control group while bone resorption indexes TRACP and CTX contents were significantly lower than those of control group. Conclusions: Jintiange capsule-assisted internal fixation can effectively improve the calcium and phosphorus metabolism, optimize bone formation/bone resorption balance and promote fracture healing in patients with Colles fracture.

基于聚醚胺(PEA)动态交联网络的多重响应性表面褶皱图案

刺激响应性表面图案赋予了材料动态可调的表面性能,是智能材料领域研究的热点,然而如何通过简单有效的方法构建这类动态表面图案也是该领域的难点.本文将动态硼酸酯键和光可逆二聚基团引入到聚醚胺(PEA)交联网络中,通过双层褶皱体系构建一系列具有光和湿度刺激响应性表面褶皱图案.在365 nm紫外光照和加热的条件下,蒽基团(AN)的光二聚与硼酸键的形成使得上表层聚醚胺模量变大,产生微米级表面褶皱图案;在254 nm紫外光照射或水蒸气作用下,聚醚胺网络解交联,表面褶皱图案消失;利用光化学时空分辨的特性,通过光掩膜板光照还可以制备多层次动态表面褶皱图案.这种多重刺激响应性表面褶皱图案为构建智能聚合物表面提供了新思路,在传感和防伪等领域具有潜在的应用前景.

Combining photo-cleavable and hydrogen-abstracting groups in quinoxaline with thioether bond as hybrid photoinitiator

We synthesized four diphenylquinoxaline derivatives（SQs） with phenyl-thioether units, which combine photo-cleavable and hydrogen-abstracting groups in one molecule. The photochemistry and photopolymerization of SQs were investigated. SQs possess suitable UV-vis absorption in the range of 350-400 nm with high extinction coefficients. UV-vis and HPLC-MS spectra revealed that C–S bond in phenyl-thioether group of SQs can be broken by irradiation of UV-light. Photolysis and photopolymerization experiments showed that SQs can be used as photo-cleavable photointiators,their photoinitiating efficiency can be enhanced by hydrogen donor. As photo-cleavable photoinitiators,SQs could initiate hexamethylene diacrylate（HDDA） very efficiently with the double bond conversion（DBC） of 80%. In the presence of ethyl-4-（dimethylamino） benzoate（EDB） as coinitiator, photoinitiator systems initiated photopolymerization of commercial acrylate monomers with higher double bond conversion than 90%. These characteristics make SQs potential photoinitiators in photo-curing field.

Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors

Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide.Based on our continuous modifications on the benzophenone derivatives as HIV-1 reverse transcriptase（RT）inhibitors,a new template bearing N-phenylbenzenesulfonamide（PBSA） structure was designed to enhance the interactions with HIV-1 RT.In this manuscript,a series of PBSA derivatives were synthesized and evaluated for their anti-HIV-1 activity.The preliminary test showed that these compounds were potent to inhibit wild-type HIV-1 with EC_（50） values ranging of 0.105-14.531 μmol/L.In particular,compound 13 f not only has high anti-HIV-1 activity（0.108 μmol/L）,but also possesses low toxicity with a Tl value of 1816.6.Furthermore,the major interactions of the inhibitor 13 f with HIV-1 RT were also investigated using the molecular modelling.Our discovered structure-activity relationships（SARs） of these analogues may serve as an important clue for further optimizations.

Effective field theory approach to lepton number violatingτdecays

We continue our endeavor to investigate lepton number violating(LNV)processes at low energies in the framework of effective field theory(EFT).In this work we study the LNV tau decaysτ^(+)→lP_(i)^(+)P_(J)^(+),where L=e.μand P_(i,j)^(+)denote the lowest-lying charged pseudoscalarsπ^(+),K^(+).We analyze the dominant contributions in a series of EFTs from high to low energy scales,namely the standard model EFT(SMEFT),the low-energy EFT(LEFT),and the chiral perturbation theory(χPT).The decay branching ratios are expressed in terms of the Wilson coefficients of dimension-five and-seven operators in SMEFT and the hadronic low-energy constants.These Wilson coefficients involve the first and second generations of quarks and all generations of leptons;thus,they cannot be explored in low-energy processes such as nuclear neutrinoless double beta decay or LNV kaon decays.Unfortunately,the current experimental upper bounds on the branching ratios are too weak to set useful constraints on these coefficients.Alternatively,if we assume the new physics scale is larger than 1 TeV,the branching ratios are well below the current experimental bounds.We also estimate the hadronic uncertainties incurred in applyingχPT toτdecays by computing one-loop chiral logarithms and attempt to improve the convergence of chiral perturbation by employing dispersion relations in the short-distance part of the decay amplitudes.