Terahertz polarization devices are an important part of terahertz optical systems.Traditional terahertz polarization devices rely on birefringent crystals,and their performances are limited by the material structures....Terahertz polarization devices are an important part of terahertz optical systems.Traditional terahertz polarization devices rely on birefringent crystals,and their performances are limited by the material structures.In this work,we theoretically demonstrate that the metamaterial consisting of the medium and the periodic metal band embedded in the medium can control broadband polarization effectively.The transmission length of the subwavelength waveguide mode gives rise to a broadband transmission peak.The resonant cavity structure formed by the dielectric layer and the waveguide layer possesses a high transmission efficiency.By optimizing the metamaterial structure parameters,we design a high-efficient(>90%)quarter-wave plate over a frequency range of 0.90 THz-1.10 THz and a high-efficient(>90%)half-wave plate over a frequency range of 0.92 THz-1.02 THz.Besides,due to the anisotropy of the structure,the metamaterials with the same structural parameters can achieve the function of the polarized beam splitting with an efficiency of up to 99%over a frequency range of 0.10 THz-0.55 THz.Therefore,the designed metamaterial has a multifunctional polarization control effect,which has potential applications in the terahertz integrated polarization optical system.展开更多
Platelets are reprogrammed by cancer via a process called education,which favors cancer development.The transcriptional profile of tumor-educated platelets(TEPs)is skewed and therefore practicable for cancer detection...Platelets are reprogrammed by cancer via a process called education,which favors cancer development.The transcriptional profile of tumor-educated platelets(TEPs)is skewed and therefore practicable for cancer detection.This intercontinental,hospital-based,diagnostic study included 761 treatment-naive inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers(China,n=3;Netherlands,n=5;Poland,n=1)between September 2016 and May 2019.The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese(VC1 and VC2)and the European(VC3)validation cohorts collectively and independently.Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets.The AUCs for TEPs in the combined validation cohort,VC1,VC2,and VC3 were 0.918(95%CI 0.889-0.948),0.923(0.855-0.990),0.918(0.872-0.963),and 0.887(0.813-0.960),respectively.Combination of TEPs and CA125 demonstrated an AUC of 0.922(0.889-0.955)in the combined validation cohort;0.955(0.912-0.997)in VC1;0.939(0.901-0.977)in VC2;0.917(0.824-1.000)in VC3.For subgroup analysis,TEPs exhibited an AUC of o.858,0.859,and 0.920 to detect early-stage,borderline,non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis.TEPs had robustness,compatibility,and universality for preop.erative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities,heterogeneous histoiogical subtypes,and early-stage ovarian cancer.However,these observations warrant prospective validations in a larger population beforeclinicalutilities.展开更多
基金Project supported by the National Key Research and Development Plan,China(Grant No.2016YFB0402402)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB43010000)+5 种基金the National Key Research and Development Project,China(Grant No.2016YFB0400601)the National Basic Research Program of China(Grant No.2015CB351902)the National Science and Technology Major Project,China(Grant No.2018ZX01005101-010)the National Natural Science Foundation of China(Grant Nos.61835011and U1431231)the Key Research Projects of Frontier Science of the Chinese Academy of Sciences(Grant No.QYZDY-SSW-JSC004)the Beijing Science and Technology Projects(Grant No.Z151100001615042).
文摘Terahertz polarization devices are an important part of terahertz optical systems.Traditional terahertz polarization devices rely on birefringent crystals,and their performances are limited by the material structures.In this work,we theoretically demonstrate that the metamaterial consisting of the medium and the periodic metal band embedded in the medium can control broadband polarization effectively.The transmission length of the subwavelength waveguide mode gives rise to a broadband transmission peak.The resonant cavity structure formed by the dielectric layer and the waveguide layer possesses a high transmission efficiency.By optimizing the metamaterial structure parameters,we design a high-efficient(>90%)quarter-wave plate over a frequency range of 0.90 THz-1.10 THz and a high-efficient(>90%)half-wave plate over a frequency range of 0.92 THz-1.02 THz.Besides,due to the anisotropy of the structure,the metamaterials with the same structural parameters can achieve the function of the polarized beam splitting with an efficiency of up to 99%over a frequency range of 0.10 THz-0.55 THz.Therefore,the designed metamaterial has a multifunctional polarization control effect,which has potential applications in the terahertz integrated polarization optical system.
文摘Platelets are reprogrammed by cancer via a process called education,which favors cancer development.The transcriptional profile of tumor-educated platelets(TEPs)is skewed and therefore practicable for cancer detection.This intercontinental,hospital-based,diagnostic study included 761 treatment-naive inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers(China,n=3;Netherlands,n=5;Poland,n=1)between September 2016 and May 2019.The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese(VC1 and VC2)and the European(VC3)validation cohorts collectively and independently.Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets.The AUCs for TEPs in the combined validation cohort,VC1,VC2,and VC3 were 0.918(95%CI 0.889-0.948),0.923(0.855-0.990),0.918(0.872-0.963),and 0.887(0.813-0.960),respectively.Combination of TEPs and CA125 demonstrated an AUC of 0.922(0.889-0.955)in the combined validation cohort;0.955(0.912-0.997)in VC1;0.939(0.901-0.977)in VC2;0.917(0.824-1.000)in VC3.For subgroup analysis,TEPs exhibited an AUC of o.858,0.859,and 0.920 to detect early-stage,borderline,non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis.TEPs had robustness,compatibility,and universality for preop.erative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities,heterogeneous histoiogical subtypes,and early-stage ovarian cancer.However,these observations warrant prospective validations in a larger population beforeclinicalutilities.