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Effect of Chinese medicine prescriptions of warming-Yang or cooling-heat combined with Gefitinib on H1650 cell line 被引量:1
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作者 Yan-Juan Zhu Zou Ying +5 位作者 Hui-Hui Chen xiao-feng jiang Xian Chen Li-Rong Liu Yi-Hong Liu Hai-Bo Zhang 《TMR Cancer》 2018年第1期22-28,共7页
目的:探索两个相反治则的温阳、清热中药联合靶向药物吉非替尼对H1650细胞的生长、凋亡及表皮生长因子受体(EGFR)通路的影响.方法:培养并收集对数生长期的H1650细胞,利用MTT法计算吉非替尼单药的IC50,再联合不同浓度的参附、清开灵... 目的:探索两个相反治则的温阳、清热中药联合靶向药物吉非替尼对H1650细胞的生长、凋亡及表皮生长因子受体(EGFR)通路的影响.方法:培养并收集对数生长期的H1650细胞,利用MTT法计算吉非替尼单药的IC50,再联合不同浓度的参附、清开灵注射液,作用48、72小时,MTT法检测联合药物对细胞株的増殖抑制率,计算Q值比较联合效应,选择联合指数差异较大的药物浓度、作用时间点,通过Annexin V/PI法检测药物对细胞凋亡的影响.Westernblot法检测EGFR通路相关蛋白的表达.结果:与单药相比,QKL联合吉非替尼显着抑制H1650细胞増殖并诱导细胞凋亡(P〈0.05).相反,SF和吉非替尼对细胞活力抑制和细胞凋亡均具有显着的诘抗作用(48h:0.85〈Q〈1.15,72h:Q〈0.85).吉非替尼组EGFR蛋白表达水平明显低于吉非替尼组,但p-EGFR在各组间变化不明显(P〉0.05).下游蛋白分子AKT/p-AKT,ERK/p-ERK表达在吉非替尼,吉非替尼+SF和吉非替尼+QKL组均无显著差异(P〉0.05).结论:清开灵注射液与吉非替尼对H1650细胞具有协同抑制效应,其机制可能是下调EGFR的表达进而改善H1650细胞对EGFR-TKIs的耐药. 展开更多
关键词 清开灵 参附 吉非替尼 非小细胞肺癌
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Improvement on application of Dancoff factor and resonance interference table
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作者 Yu Han xiao-feng jiang De-Zhong Wang 《Nuclear Science and Techniques》 SCIE CAS CSCD 2016年第2期122-130,共9页
An improvement for application of Dancoff factor is developed. It combines Stamm'ler's two-term method for resonance integral calculation with neutron current method for Dancoff factor calculation. Stamm'l... An improvement for application of Dancoff factor is developed. It combines Stamm'ler's two-term method for resonance integral calculation with neutron current method for Dancoff factor calculation. Stamm'ler's formulation, which is originally derived for the infinite lattice geometry, can be easily revised to contain the Dancoff factor explicitly, while the neutron current method can easily calculate the Dancoff factor for general irregular assembly geometry. For the resonance interference effects the resonance interference factor table is built in pairs of nuclides, only for the interference between 238 U and other resonance nuclides, spanning over a range of background cross-section and number density ratio of the pairing nuclides. A series of verification calculations have been carried out for problems of infinite lattice and single assembly geometry, with two or multiple resonance absorbers. For these verification calculations, our improvement on Dancoff factor application and resonance interference give good results. 展开更多
关键词 共振干涉 因子和 应用 积分计算 几何形状 干涉效应 中子流 核素
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Positive-Negative Emotional Categorization of Clothing Color Based on Brightness
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作者 xiao-feng jiang Xiao-Pei Bian 《Engineering(科研)》 2013年第10期189-194,共6页
In current study, behavioral measures were conducted to investigate clothing color. The purpose was to focus on the rule that color brightness influencedpositive-negative emotional categorization. Results showed that ... In current study, behavioral measures were conducted to investigate clothing color. The purpose was to focus on the rule that color brightness influencedpositive-negative emotional categorization. Results showed that the effect of brightness on clothing color emotion categorization was significant. With the increase of brightness, the variation curve of positive emotion appears to be a “U-shaped”, whereas that of the negative emotion shows an upside down “U-shaped”. Compared with the low brightness colors, the emotion reaction to the high brightness colors was more positive;Most of the colors with different brightness scales were classified as positive emotions and the minors were classified as negative emotions;the positive colors could be done much faster than the negative ones. 展开更多
关键词 COLOR EMOTION Response Time BRIGHTNESS CATEGORIZATION Positive-Negative
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Optimal Content Placement and Request Dispatching for Cloud-based Video Distribution Services 被引量:1
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作者 Zheng-Huan Zhang xiao-feng jiang Hong-Sheng Xi 《International Journal of Automation and computing》 EI CSCD 2016年第6期529-540,共12页
The rapid progress of cloud technology has attracted a growing number of video providers to consider deploying their streaming services onto cloud platform for more cost-effective, scalable and reliable performance. I... The rapid progress of cloud technology has attracted a growing number of video providers to consider deploying their streaming services onto cloud platform for more cost-effective, scalable and reliable performance. In this paper, we utilize Markov decision process model to formulate the dynamic deployment of cloud-based video services over multiple geographically distributed datacenters. We focus on maximizing the average profits for the video service provider over a long run and introduce an average performance criteria which reflects the cost and user experience jointly. We develop an optimal algorithm based on the sensitivity analysis and sample-based policy iteration to obtain the optimal video placement and request dispatching strategy. We demonstrate the optimality of our algorithm with theoretical proof and specify the practical feasibility of our algorithm. We conduct simulations to evaluate the performance of our algorithm and the results show that our strategy can effectively cut down the total cost and guarantee users' quality of experience (QoE). 展开更多
关键词 Cloud computing video distribution Markov decision process sensitivity analysis policy iteration.
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